A5059306287- Influenza Virus Research Studies
- Bacteriophages and microbial interactions
- interferon and immune responses
- SARS-CoV-2 and COVID-19 Research
- Antibiotic Resistance in Bacteria
- Monoclonal and Polyclonal Antibodies Research
- Parvovirus B19 Infection Studies
- Genomics and Phylogenetic Studies
- Tea Polyphenols and Effects
- Polyomavirus and related diseases
- Microbial infections and disease research
- Enzyme Structure and Function
- RNA and protein synthesis mechanisms
- Gut microbiota and health
- Respiratory viral infections research
- Mycotoxins in Agriculture and Food
- Vibrio bacteria research studies
- Plant Virus Research Studies
- Fungal Biology and Applications
- Cytokine Signaling Pathways and Interactions
- RNA regulation and disease
- Adenosine and Purinergic Signaling
- Innovative Microfluidic and Catalytic Techniques Innovation
- Cytomegalovirus and herpesvirus research
- Metastasis and carcinoma case studies
Beijing Luhe Hospital Affiliated to Capital Medical University
2025
Shanghai Public Health Clinical Center
2020-2024
Xinyang Normal University
2019-2024
Hefei University of Technology
2024
The First Affiliated Hospital, Sun Yat-sen University
2024
Fudan University
2019-2024
Shanghai Skin Disease Hospital
2024
Central People's Hospital of Zhanjiang
2024
Pharmaceutical Biotechnology (Czechia)
2024
State Key Laboratory of Pharmaceutical Biotechnology
2024
Phage therapy is recognized as a promising alternative to antibiotics in treating pulmonary bacterial infections, however, its use has not been reported for secondary infections during virus pandemics such coronavirus disease 2019 (COVID-19). We enrolled 4 patients hospitalized with critical COVID-19 and carbapenem-resistant Acinetobacter baumannii (CRAB) compassionate phage (at 2 successive doses of 109 plaque-forming unit phages). All our COVID-19-specific intensive care (ICU) CRAB...
Abstract CreTA, CRISPR-regulated toxin-antitoxin (TA), safeguards CRISPR-Cas immune systems by inducing cell dormancy/death upon their inactivation. Here, we characterize a bacterial CreTA associating with the I-F in Acinetobacter . CreT is distinct bactericidal small RNA likely targeting several essential molecules that are required to initiate protein synthesis. CreA guides CRISPR effector transcriptionally repress CreT. We further demonstrate proof-of-concept antimicrobial strategy named...
Abstract Accumulating evidence shows that innate immune responses are associated with extracellular nucleotides, particularly ATP. In this article, we demonstrate extensive protection of ATP/P2X7 signaling in a host against viral infection. Interestingly, observed significant increase ATP as danger signal vesicular stomatitis virus (VSV)-infected cell supernatant and VSV-infected mice an exocytosis- pannexin channel–dependent manner. Furthermore, reduces the replication VSV, Newcastle...
IFITMs are broad antiviral factors that block incoming virions in endosomal vesicles, protecting target cells from infection. In the case of HIV-1, we and others reported existence an additional mechanism through which lead to production reduced infectivity. However, whether this second inhibition is unique HIV or extends other viruses currently unknown. To address question, have analyzed susceptibility a spectrum negative imprinting virion particles infectivity by IFITMs. The results...
Bisphenol A (BPA), an environmental endocrine-disrupting compound, has drawn a great attention for its adverse effect on behavioral development. Maternal exposure to this compound been reported induce anxiety and depression in offspring, but the of paternal is rarely discussed. This study investigated whether preconception BPA can affect emotions male rats their offspring. Eighteen adult (F0) received either vehicle or 50 μg/kg/day diet 21 weeks were then mated with non-exposed females...
Abstract Background Catechins, caffeine, and theanine as three important metabolites in the tea leaves play essential roles formation of specific taste shows potential health benefits to humans. However, knowledge on dynamic changes these content over seasons, well candidate regulatory factors, remains largely undetermined. Results An integrated transcriptomic metabolomic approach was used analyze mainly including catechins, theanine, explore influencing factors associated with course...
ISG20 is a broad spectrum antiviral protein thought to directly degrade viral RNA. However, this mechanism of inhibition remains controversial. Using the Vesicular Stomatitis Virus (VSV) as model RNA virus, we show here that interferes with replication by decreasing synthesis in absence degradation. Importantly, demonstrate exerts translational control over large panel non-self substrates including those originating from transfected DNA, while sparing endogenous transcripts. This activity...
Multidrug-resistant (MDR) organisms have increased worldwide, posing a major challenge for the clinical management of infection. Bacteriophage is expected as potential effective therapeutic agents difficult-to-treat infections. When performing bacteriophage therapy, susceptibility lytic to target bacteria selected by laboratory isolate from patients. The presence subpopulation in main population tested cells, coupled with rapid development phage-resistant populations, will make therapy...
MicroRNAs are a class of small noncoding RNAs that function as key regulators gene expression at the post-transcriptional level. Recently, microRNA-373 (miR-373) has been found to an oncogene in testicular germ cell tumors. In our study, we miR-373 is upregulated human hepatocellular carcinoma (HCC) tissues compared with adjacent normal tissues, and promotes proliferation HCC lines HepG2 QGY-7703 by regulating transition between G(1)-phase S-phase. The encoding protein phosphatase 6...
Abstract A double‐stranded RNA (dsRNA) phage phiYY is able to kill a pyomelanin‐producing Pseudomonas aeruginosa strain, which was isolated from 40‐year‐old man with interstitial lung disease (ILD) and chronic infection. Phage therapy used as last resort for this patient. The three‐course nebulized treatment reduce the bacterial burden clinical symptoms of Recurrences P. infections were observed 1–3 days post therapy. recurrent isolates exhibited distinct antibiotic‐susceptibility profiles...
Left ventricular hypertrophy (LVH), a hallmark of early-stage heart failure (HF), is common complication in individuals with type 2 diabetes mellitus (T2DM). Metabolic Visceral Fat Score (METS-VF), novel metric for estimating visceral adiposity, may provide valuable insights into LVH risk. This study explores the association between METS-VF and T2DM compare its predictive performance to traditional abdominal obesity indices. cross-sectional included 4,988 adults T2DM. Participants were...
Abstract To maintain genome integrity, repeat sequences are subject to heterochromatin inactivation and, in Neurospora, repeat-induced point mutation (RIP). The initiating factors behind both poorly understood. We resolve the paradoxical observation that newly introduced Repeat-Linker-Repeat (R-L-R) constructs require RID alone for RIP, while genomic repeats RIPed absence of RID, showing eu- and hetero- chromatic handled differently, latter additionally requiring DIM-2. differences between...
Controlling aflatoxigenic Aspergillus flavus and aflatoxins (AFs) in grains food during storage is a great challenge to humans worldwide. Alcaligenes faecalis N1-4 isolated from tea rhizosphere soil can produce abundant antifungal volatiles, greatly inhibited the growth of A. un-contacted face-to-face dual culture testing. Gas chromatography tandem mass spectrometry revealed that dimethyl disulfide (DMDS) methyl isovalerate (MI) were two compounds volatile profiles N1-4. DMDS was found have...
Resveratrol (RES), a dietary polyphenol compound, has been shown to possess health benefits due its anti-inflammatory, antioxidative, and antiatherosclerosis properties. Tryptophan metabolite-derived indoxyl sulfate (IS) is identified as one of the uremic toxins physiological endogenous ligand/activator aryl hydrocarbon receptor (AHR), associated with atherosclerosis in chronic kidney disease (CKD) patients. Studies have that high serum level IS causes deleterious effects on primarily by...
Antimicrobial resistance (AMR) by bacteria is a serious global threat, and rapid, high-throughput, easy-to-use phenotypic antimicrobial susceptibility testing (AST) method essential for making timely treatment decisions controlling the spread of antibiotic resistant micro-organisms. Traditional culture-based methods are time-consuming, their capability to screen against large number different conditions limited; meanwhile genotypic based methods, including sequencing PCR constrained rarely...
Abstract Bacteriophages can help the treatment of bacterial infections yet require in-silico models to deal with great genetic diversity between phages and bacteria. Despite tolerable prediction performance, application scope current approaches is limited at species level, which cannot accurately predict relationship across strain mutants. This has hindered development phage therapeutics based on phage–bacteria relationships. In this paper, we present, PB-LKS, interaction local K-mer...