A5103078846- Genetic Associations and Epidemiology
- Genetic and phenotypic traits in livestock
- Intraocular Surgery and Lenses
- Corneal surgery and disorders
- Nutrition, Genetics, and Disease
- Pain Mechanisms and Treatments
- Genetic Mapping and Diversity in Plants and Animals
- Corneal Surgery and Treatments
- Pharmacological Effects of Natural Compounds
- RNA modifications and cancer
- COVID-19 epidemiological studies
- Advanced Causal Inference Techniques
- Neuroinflammation and Neurodegeneration Mechanisms
- Cardiovascular Health and Risk Factors
- Viral Infections and Vectors
- Genomics, phytochemicals, and oxidative stress
- Liver Disease Diagnosis and Treatment
- Vector-borne infectious diseases
- COVID-19 Clinical Research Studies
- Genetics and Neurodevelopmental Disorders
- Cancer-related molecular mechanisms research
- COVID-19 and healthcare impacts
- Microbial infections and disease research
- Diet and metabolism studies
- Botulinum Toxin and Related Neurological Disorders
Southwest Medical University
2024
University of Southern California
2020-2024
University of North Carolina at Chapel Hill
2024
University of Science and Technology of China
2024
University of Iowa
2020-2023
Baylor Scott & White Medical Center - Temple
2023
Universidad Autónoma de Madrid
2021
Harvard University
2017-2021
XinHua Hospital
2021
Johns Hopkins University
2018
The development of antinociceptive tolerance following repetitive administration opioid analgesics significantly hinders their clinical use. Evidence has accumulated indicating that microglia within the spinal cord plays a critical role in morphine tolerance. inhibitor is effective to attenuate tolerance; however, mechanism not fully understood. Our present study investigated effects and possible natural product procyanidins improving via its specific inhibition on NOD-like receptor protein3...
Background The majority of the critically ill patients may have critical illness-related corticosteroid insufficiency (CIRCI). therapeutic effect dexamethasone be related to its ability improve cortical function. Recent study showed that can reduce COVID-19 deaths by up one third in patients. aim this article is investigate whether SARS-CoV-2 attack adrenal cortex aggravate relative insufficiency. Methods We summarized clinical features reported currently available observational studies....
The development of wearable electronic devices for human health monitoring requires materials with high mechanical performance and sensitivity. In this study, we present a novel transparent tissue-like ionogel-based sensor based on silver nanowire-reinforced ionogel nanocomposites, P(AAm-co-AA) ionogel-Ag NWs composite. composite exhibits stretchability 605% strain moderate fracture stress about 377 kPa. also demonstrates sensitive response to temperature changes electrostatic adsorption. By...
Tolerance seriously impedes the application of morphine in clinical medicine. Thus, it is necessary to investigate exact mechanisms and efficient treatment. Microglial activation neuroinflammation spinal cord are thought play pivotal roles on genesis maintaining tolerance. Activation adenosine monophosphate-activated kinase (AMPK) has been associated with inhibition inflammatory nociception. Metformin, a biguanide class antidiabetic drugs activator AMPK, potential anti-inflammatory effect....
Activated astrocytes release matrix metalloproteinase-2/9 (MMP-2/9) to induce central sensitization and maintain neuropathic pain. However, the mechanisms involved in activation of MMP-2/9 on during pain remain poorly understood. Meanwhile, there is a lack effective treatment inhibit astrocytes. In this study, we aim investigate effect tetramethylpyrazine (TMP), natural compound with analgesic effects but unknown mechanisms, pain.The nociception was assessed by measuring incidence foot...
Excessive energy intake or insufficient expenditure, which result in imbalance, contribute to the development of obesity. Obesity-related genes, such as FTO, are associated with traits. No genome-wide association studies (GWAS) have been conducted detect genetic associations energy-related traits, including and among European-ancestry populations. In this study, we a study using pooled GWAS 12,030 women 6,743 men identify variants these two We observed statistically significant SNP...
Objective This study aimed to uncover genetic contributors adiposity in early life. Methods A genome‐wide association of childhood body fatness 34,401 individuals within the Nurses’ Health Studies and Professionals Follow‐up Study was conducted. Data were imputed 1000 Genomes Phase 3 version 5 reference panel. Results total 1,354 single‐nucleotide polymorphisms ( P < 10 −4 ) selected for replication a previously published BMI. Nineteen significant × −8 regions observed, fourteen which...
Abstract Recent advancement in genome‐wide association studies (GWAS) comes from not only increasingly larger sample sizes but also the shift focus towards underrepresented populations. Multipopulation GWAS increase power to detect novel risk variants and improve fine‐mapping resolution by leveraging evidence differences linkage disequilibrium (LD) diverse Here, we expand upon our previous approach for single‐population through Joint Analysis of Marginal SNP Effects (JAM) a multipopulation...
Cigarette smoking is a major environmental risk factor for many diseases, including chronic obstructive pulmonary disease (COPD). There are shared genetic influences on cigarette and COPD. Genetic factors in cohorts enriched COPD largely unknown.We performed genome-wide association analyses average cigarettes per day (CPD) across the Epidemiology of (COPDGene) non-Hispanic white (NHW) (n = 6659) African American (AA) 3260), GenKOLS (the Genetics Chronic Obstructive Lung Disease) 1671),...
Abstract Background: Obesity and diabetes are major modifiable risk factors for pancreatic cancer. Interactions between genetic variants diabetes/obesity have not previously been comprehensively investigated in cancer at the genome-wide level. Methods: We conducted a gene–environment interaction (GxE) analysis including 8,255 cases 11,900 controls from four association study (GWAS) datasets (Pancreatic Cancer Cohort Consortium I–III Pancreatic Case Control Consortium). (body mass index ≥30...
Health disparities have emerged with the COVID-19 epidemic because risk of exposure to infection and prevalence factors for severe outcomes given vary within between populations. However, estimated quantities such as rates illness death, case fatality rate (CFR), (IFR), are often expressed in terms aggregated population-level estimates due lack epidemiological data at refined subpopulation level. For public health policy makers better address pandemic, stratified necessary investigate...
Abstract Previous research has demonstrated the usefulness of hierarchical modeling for incorporating a flexible array prior information in genetic association studies. When this consists estimates from analyses single-nucleotide polymorphisms (SNP)-intermediate or SNP-gene expression, model is equivalent to 2-stage instrumental transcriptome-wide study (TWAS) analysis, respectively. We propose extend our previous approach joint analysis marginal summary statistics incorporate via (hJAM). In...
The objective of this study was to use available data on the prevalence COVID-19 risk factors in subpopulations and epidemic dynamics at population level estimate probabilities severe illness case infection fatality rates (CFR IFR) stratified across subgroups representing all combinations age, comorbidities, obesity, smoking status. We focus first year Los Angeles County (LAC) (March 1, 2020–March 2021), spanning three waves. A relative modeling approach developed conditional effects from...
Abstract Recent advancement in Genome-wide Association Studies (GWAS) comes from not only increasingly larger sample sizes but also the shifted focus towards underrepresented populations. Multi-population GWAS may increase power to detect novel risk variants and improve fine-mapping resolution by leveraging evidence diverse populations accounting for difference linkage disequilibrium (LD) across ethnic groups. Here, we expand upon our previous approach single-population through Joint...
Instrumental variable (IV) analysis has been widely applied in epidemiology to infer causal relationships using observational data. Genetic variants can also be viewed as valid IVs Mendelian randomization and transcriptome-wide association studies. However, most multivariate IV approaches cannot scale high-throughput experimental Here, we leverage the flexibility of our previous work, a hierarchical model that jointly analyzes marginal summary statistics (hJAM), scalable framework (SHA-JAM)...
Purpose: Epithelial downgrowth is a vision-threatening complication of intraocular surgery or penetrating ocular trauma, and although various therapeutic interventions have been performed to treat this disease, success has limited. We present case corneal decompensation secondary epithelial after uncomplicated clear cataract in the left eye, treated successfully with sequential transcorneal cryotherapy destroy cell nests followed by Descemet membrane endothelial keratoplasty (DMEK) restore...
Abstract Background Previous research has demonstrated the usefulness of hierarchical modeling for incorporating a flexible array prior information in genetic association studies. When this consists effect estimates from analyses single nucleotide polymorphisms (SNP)-intermediate or SNP-gene expression, model is equivalent to two-stage instrumental transcriptome-wide study (TWAS) analysis, respectively. Methods We propose extend our previous approach joint analysis marginal summary...
La población china nativa de la Comunidad Madrid es muy numerosa. El objetivo del estudio fue analizar su prevalencia factores riesgo cardiovascular (FRCV). Hemos hecho un muestreo conveniencia con: edad, género, presión arterial, peso, altura, índice masa corporal, glucemia, colesterol total, triglicéridos, tabaquismo, hipertensión arterial (HTA) y diabetes mellitus (DM). Se analizó HTA, DM, sobrepeso (índice corporal ≥ 24 kg/m2) dislipidemia (colesterol total 200 mg/dl o triglicéridos 150...
Purpose: The aim of this study was to define risks for corneal transplantation associated with fibrous ingrowth among first-time transplant recipients. Methods: We performed a retrospective case–control patients histopathologic diagnosis between 2002 and 2019. Patients from first specimen were included. Those incomplete records excluded. A 1:2 ratio used. Controls matched using surgical indication, surgery year, method, sex, age. Results: Seventy-eight eyes (76 patients) included 160 control...