A5101660456- Gastrointestinal disorders and treatments
- Pancreatitis Pathology and Treatment
- Pancreatic and Hepatic Oncology Research
- Clostridium difficile and Clostridium perfringens research
- Gut microbiota and health
- Sepsis Diagnosis and Treatment
- Helicobacter pylori-related gastroenterology studies
- Immune cells in cancer
- Microscopic Colitis
- Evaluation and Optimization Models
- Thermal Regulation in Medicine
- Pain Mechanisms and Treatments
- Respiratory Support and Mechanisms
- Diagnosis and Treatment of Venous Diseases
- Obstructive Sleep Apnea Research
- Inflammatory Bowel Disease
- Trauma, Hemostasis, Coagulopathy, Resuscitation
- Venous Thromboembolism Diagnosis and Management
- Non-Invasive Vital Sign Monitoring
- Pharmacological Effects of Natural Compounds
- Cancer, Hypoxia, and Metabolism
- COVID-19 Clinical Research Studies
- Engineering Diagnostics and Reliability
- Optical Network Technologies
- Ion channel regulation and function
Chinese PLA General Hospital
2016-2025
University of Alberta
2025
XinHua Hospital
2007-2024
Shanghai Jiao Tong University
2009-2024
Zhejiang Hospital
2021
Chinese People's Liberation Army
2020
Second Military Medical University
2017-2020
Eastern Hepatobiliary Surgery Hospital
2017-2020
Fudan University
2017
Shanghai Public Health Clinical Center
2017
The changes of gastric microbiome across stages neoplastic progression remain poorly understood, especially for intraepithelial neoplasia (IN) which has been reorganized as a phenotypic bridge between atrophic/metaplastic lesions and invasive cancer. microbiota was investigated in 30 healthy controls (HC), 21 non-atrophic chronic gastritis (CG), 27 intestinal metaplasia (IM), 25 IN 29 cancer (GC) patients by 16S rRNA gene profiling. bacterial diversity, abundances phyla Armatimonadetes,...
Background The majority of the critically ill patients may have critical illness-related corticosteroid insufficiency (CIRCI). therapeutic effect dexamethasone be related to its ability improve cortical function. Recent study showed that can reduce COVID-19 deaths by up one third in patients. aim this article is investigate whether SARS-CoV-2 attack adrenal cortex aggravate relative insufficiency. Methods We summarized clinical features reported currently available observational studies....
Abstract Background The fecal microbiota in pancreatic ductal adenocarcinoma (PDAC) and autoimmune pancreatitis (AIP) patients remains largely unknown. We aimed to characterize the with PDAC AIP, explore possibility of microbial biomarkers for distinguishing AIP. Methods 32 PDAC, AIP age- sex-matched healthy controls (HC) were recruited microbiotas analyzed through high-throughput metagenomic sequencing. Alterations short-chain fatty acids measured using gas chromatographic method. Results...
Abstract Proton pump inhibitors (PPIs) are commonly used to lessen symptoms in patients with gastroesophageal reflux disease (GERD). However, the effects of PPI therapy on gastrointestinal microbiota GERD remain unclear. We examined association between usage and present gastric mucosal fecal samples from healthy controls (HCs) using 16S rRNA gene sequencing. taking PPIs were further divided into short-term long-term user groups. showed that administration lowered relative bacterial diversity...
The success of any Intrusion Detection Systems (IDSs) is a complicated problem due to its nonlinearity and the quantitative or qualitative network traffic data stream with irrelevant redundant features. How choose effective key features very important topic for an intrusion detection problem. Support vector machine (SVM) has been employed provide potential solutions IDSs However, practicability SVM affected difficulty selecting appropriate parameters. Artificial Bee Colony algorithm (ABC)...
Therapies for Tourette syndrome (TS) are insufficient, and novel therapies needed. Fecal microbiota transplantation (FMT) has been a potential therapy several neurological diseases. Here, we report preliminary study to investigate the effects of FMT on patients with TS. Five TS received single administration via endoscopy. Tic symptoms were assessed by Yale Global Severity Scale-Total Score (YGTSS-TTS) adverse recorded at week 8 following FMT. Lipopolysaccharide (LPS) levels 14 cytokines...
Deep vein thrombosis (DVT) has become a severe disease with rising incidence rate. The conventional diagnosis relies on complicated imaging modalities that may also involve invasive contrast agent injection and ionizing procedures (e.g., venography). Noninvasive near-infrared spectroscopy (NIRS) methods have been explored which required the DVT patients to follow some exercise protocols. Here, we attempt use portable NIRS under patients' natural state for diagnosis. Nine seven healthy...
Aims : To assess the long-term efficacy and safety of single-donor, low-intensity fecal microbiota transplantation (FMT) in treating ulcerative colitis (UC), to identify outcome-specific gut bacteria. Design: Thirty-one patients with active UC (Mayo scores ≥ 3) were recruited, all received FMT twice, at start study 2∼3 months later, respectively, a single donor follow-up. The microbiome profile was accessed via 16S rRNA sequencing before after FMT. Results: After first FMT, 22.58% (7/31)...
Background: Polymyxin B (PMB)-based combination therapies are used to treat severe carbapenem-resistant gram-negative bacterial (CR-GNB) infections. This observational study investigated the relationship between clinical factors, including PMB concentration, and efficacy safety. Patients Methods: regimens were optimized through therapeutic drug monitoring (TDM) area under concentration-time curve (AUC). In all, 382 samples tested from 130 patients. Logistic regression was analyze...
AIM:To explore Chinese physicians' perceptions towards fecal microbiota transplantation (FMT) and to provide information an assessment of FMT development in China. METHODS:A self-administered questionnaire was developed according the practice guidelines distributed physicians hospitals via Internet Research Electronic Data Capture (REDcap) software electronic mails assess their attitudes toward knowledge FMT.The included a brief introduction that followed by 20 questions.The participants...
Background: This study examines the microcirculation of patients with sepsis and septic shock using Laser Speckle Contrast Imaging (LSCI) technology, to enhance monitoring predict outcomes shock. Methods: From 01 July 2021, 31 January 2022, 44 diagnosed were included in study, their clinical data collected, LSCI was used monitor mean peripheral blood flow perfusion index (PI). Results: The average PI significantly lower than that patients, a cutoff value 26.25. negatively correlated acute...
BACKGROUND:Thymoma is the most common tumor of anterior mediastinum, and can be caused by infrequent malignancies arising from epithelial cells thymus. Unfortunately, blood-based diagnostic markers are not currently available. High-throughput sequencing technologies, such as RNA-seq with next-generation sequencing, have facilitated detection characterization both coding non-coding RNAs (ncRNAs), which play significant roles in genomic regulation, transcriptional post-transcriptional...
Monitoring tissue blood oxygen saturation central venous catheter.A correlation analysis between the StO 2 and ScvO of 13 samples was performed (Pearson coefficient), suggesting a high them (r = 0.906, =1.0018ScvO +2.8524).Bland-Altman also .Results were as follows: 100% monitored points fell within range mean ± 1.96 SD difference ; 3 10.2; confidence interval -7.2 to 13.2%.The with NIRS correlated highly measured in internal jugular vein.Therefore, can be used for directing clinical...
Background It is a common phenomenon that children experience multiple general anesthesias in clinical practice, which raises the question whether repeated exposure to anesthetics would interfere with development of central nervous system children. The present study was designed evaluate effects treatment ketamine or midazolam on postnatal dendrite by examining morphology dendritic spines pyramidal neurons hippocampal CA1 region mice. Methods transgenic green fluorescent protein-M line...
Abstract The characteristics of the gastric microbiota in patients with polyposis (GP) remain unclear. Given this we collected antrum and body biopsies from healthy controls (HC.A HC.B group) antrum, polyp multiple polyps (GP.A, GP.B GP.P for 16S rDNA sequencing. results showed that diversity flora GP group was significantly lower than HC group. composition different However, compositions parts stomach (gastric or tissue) were not different. H. pylori abundance could influence microbiota....
Abstract Proteomic communications in neighboring microenvironments during early organ development is a dynamic process that continuously reshapes human embryonic stem cells (hESCs) developmental fate. Such proteomic alteration the microenvironment consists of both freely secreted proteome and exosome‐encapsulated proteome. Simultaneous monitoring time‐lapse shift proteomes with live organoids remains technically challenging. Here, c ontinuous o rganoid s ecretion/ e ncapsulation p roteome...