A5100437566- Electrospun Nanofibers in Biomedical Applications
- Tissue Engineering and Regenerative Medicine
- Biopolymer Synthesis and Applications
- Cancer Research and Treatments
- Migraine and Headache Studies
- Mesenchymal stem cell research
- Reproductive Biology and Fertility
- Polyamine Metabolism and Applications
- Esophageal Cancer Research and Treatment
- Cancer-related molecular mechanisms research
- Gastric Cancer Management and Outcomes
- Bacteriophages and microbial interactions
- biodegradable polymer synthesis and properties
- Cancer, Hypoxia, and Metabolism
- Nerve injury and regeneration
- Muscle Physiology and Disorders
- Enzyme Production and Characterization
- Psychosomatic Disorders and Their Treatments
- Bone Tissue Engineering Materials
- Blood transfusion and management
- Esophageal and GI Pathology
- Biofuel production and bioconversion
- Microbial Metabolic Engineering and Bioproduction
- Periodontal Regeneration and Treatments
- Metastasis and carcinoma case studies
Nankai University
2016-2025
Shanghai University of Traditional Chinese Medicine
2025
Chinese PLA General Hospital
2015-2024
Baylor College of Medicine
2011-2024
Sarepta Therapeutics (United States)
2022-2024
Yancheng Third People's Hospital
2016-2024
Hebei Chemical and Pharmaceutical College
2024
Evive Biotech (China)
2024
Peking University Shougang Hospital
2019-2024
Affiliated Hospital of Nantong University
2023
The Montreal Cognitive Assessment (MoCA) was developed to enable earlier detection of mild cognitive impairment (MCI) relative familiar multi-domain tests like the Mini-Mental State Exam (MMSE). Clinicians need better understand relationship between MoCA and MMSE scores. For this cross-sectional study, we analyzed 219 healthy control (HC), 299 MCI, 100 Alzheimer's disease (AD) dementia cases from Disease Neuroimaging Initiative (ADNI)-GO/2 database evaluate score distributions select values...
<h3>Objective</h3> To evaluate the efficacy and safety of galcanezumab, a humanized monoclonal antibody that selectively binds to calcitonin gene-related peptide, in preventive treatment chronic migraine. <h3>Methods</h3> A phase 3, randomized, double-blind, placebo-controlled study LY2951742 patients with migraine (Evaluation Galcanezumab Prevention Chronic Migraine [REGAIN]) was 3 3-month 9-month open-label extension. Eligible 18 65 years age were randomized 2:1:1 monthly subcutaneous...
Introduction: Delandistrogene moxeparvovec (SRP-9001) is an investigational gene transfer therapy designed for targeted expression of SRP-9001 dystrophin protein, a shortened retaining key functional domains the wild-type protein. Methods: This Phase 2, double-blind, two-part (48 weeks per part) crossover study (SRP-9001-102 [Study 102]; NCT03769116) evaluated delandistrogene in patients, aged ≥4 to <8 years with Duchenne muscular dystrophy. Primary endpoints (Part 1) were change from...
The mammalian oocyte possesses powerful reprogramming factors, which can reprogram terminally differentiated germ cells (sperm) or somatic within a few cell cycles. Although it has been suggested that use of oocyte-derived transcripts may enhance the generation induced pluripotent stem cells, factors in oocytes are undetermined, and even identified proteins composition is very limited. In present study, 7,000 mouse at different developmental stages, including germinal vesicle stage,...
Abstract Introduction Young patients receiving chemotherapy occasionally face infertility and premature ovarian failure (POF). Numerous investigations reported that adipose-derived stem cells (ADSCs) transplantation could ameliorate the structure function of injured tissues. The aim this study was to explore therapeutic efficacy ADSC for chemotherapy-induced damage. Methods Female mice were injected intraperitoneally with 50 mg/kg cyclophosphamide (CTX). After 15 consecutive days injection,...
Mesenchymal stem cells, which are poorly immunogenic and have potent immunosuppressive activities, emerged as promising cellular therapeutics for the treatment of several diseases. Mesenchymal-like cells derived from Wharton’s Jelly, called umbilical cord matrix (UCMSCs), reportedly secrete a variety cytokines growth factors, acting trophic suppliers. Here, we used UCMSCs to treat premature ovarian failure (POF). Ovarian function was evaluated by ovulation number follicles. Apoptosis...
Galcanezumab, a humanized monoclonal antibody that selectively binds to the calcitonin gene-related peptide, has demonstrated in previous Phase 2 and 3 clinical studies (≤6-month of treatment) reduction number migraine headache days improved patients' functioning. This study evaluated safety tolerability, as well effectiveness galcanezumab for up 12 months treatment patients with migraine. Patients diagnosed episodic or chronic migraine, 18 65 years old, were not exposed previously...
Iturins, which belong to antibiotic cyclic lipopeptides mainly produced by Bacillus sp., have the potential for application in biomedicine and biocontrol because of their hemolytic antifungal properties. amyloliquefaciens LL3, isolated previously our lab, possesses a complete iturin A biosynthetic pathway as shown genomic analysis. Nevertheless, could not be synthesized strain possibly resulting from low transcription level itu operon. In this work, enhanced genes was implemented inserting...
Delandistrogene moxeparvovec is approved in the USA for treatment of ambulatory patients (4-5 years) with Duchenne muscular dystrophy. ENDEAVOR (SRP-9001-103; NCT04626674) a single-arm, open-label study to evaluate delandistrogene micro-dystrophin expression, safety, and functional outcomes following administration commercial process moxeparvovec.In cohort 1 (N = 20), eligible males, aged ≥4 <8 years, received single intravenous infusion (1.33 × 1014 vg/kg). The primary endpoint was change...
Delandistrogene moxeparvovec is indicated in the United States for treatment of ambulatory pediatric patients aged 4 through 5 years with Duchenne muscular dystrophy (DMD) a confirmed mutation DMD gene. Long-term delandistrogene microdystrophin protein (a shortened dystrophin that retains key functional domains wild-type protein) expression may positively alter disease progression DMD. We evaluated long-term safety and outcomes DMD.An open-label, phase 1/2a, nonrandomized controlled trial...
Small-diameter vascular grafts (SDVGs) are urgently required for clinical applications. Constructing mimicking the defining features of native arteries is a promising strategy. Here, we constructed tri-layered graft with artery decellularized extracellular matrix (dECM) component arteries. The porcine thoracic aorta was and milled into dECM powders from differential layers. intima media were blended poly (L-lactide-co-caprolactone) (PLCL) as inner middle layers electrospun grafts,...
Delandistrogene moxeparvovec is a gene transfer therapy approved in the United States, Arab Emirates, and Qatar for treatment of ambulatory patients aged 4 through 5 years with confirmed Duchenne muscular dystrophy (DMD)-causing mutation DMD gene. It was developed to address underlying cause targeted skeletal, respiratory, cardiac muscle expression delandistrogene micro-dystrophin, an engineered, functional dystrophin protein. Drawing on clinical trial experience from Study 101...
In Asian countries, squamous cell carcinoma is the most common type of esophageal cancer, and incidence gastric cancer remains have plateaued. To synthesize current information to illustrate its clinical benefit narrow band imaging (NBI) for diagnosis superficial (SESCC) early (EGC), a consensus conference was held by panel nine experts from Asian‐Pacific countries. The expert's agreement suggested importance interpretation both vascular architecture surface structure lesions proper...
Cotton is widely cultivated globally because it provides natural fibre for the textile industry and human use. To identify quantitative trait loci (QTLs)/genes associated with quality yield, a recombinant inbred line (RIL) population was developed in upland cotton. A consensus map covering whole genome constructed three types of markers (8295 markers, 5197.17 centimorgans (cM)). Six yield traits were evaluated 17 environments, 983 QTLs identified, 198 which stable mainly distributed on...
Abstract The bioinert characteristic of polycaprolactone (PCL) remains a major defect when using PCL‐based materials as small‐diameter vascular grafts for implantation in vivo . To improve the hydrophilicity, cytocompatibility, and biodegradation PCL grafts, we constructed hybrid from electrospun PCL/gelatin. PCL/gelatin graft was further functionalized with addition heparin, to hemocompatibility. This study investigated performance heparin‐loaded Our results showed that combination gelatin...
Polyhydroxyalkanoate (PHA) can be produced by microorganisms from renewable resources and is regarded as a promising bioplastic to replace petroleum-based plastics. Pseudomonas mendocina NK-01 medium-chain-length PHA (mcl-PHA)-producing strain its whole-genome sequence currently available. The yield of mcl-PHA in P. expected improved applying promoter engineering strategy. However, limited number well-characterized promoters has greatly restricted the application for increasing NK-01. In...
Several studies based on 16SrDNA analysis have revealed certain unique characteristics of gut microbiome in centenarians. We established a prospective cohort fecal microbiota and conducted the first metagenomics-based study among The objective was to explore dynamic changes healthy centenarians approaching end life unravel aging-associated microbiome. Seventy-five residing three regions Hainan participated follow-up surveys collection samples at intervals 3 months. Data pertaining dietary...