A5100647241- Tuberculosis Research and Epidemiology
- Metabolism, Diabetes, and Cancer
- COVID-19 and Mental Health
- Mycobacterium research and diagnosis
- FOXO transcription factor regulation
- Muscle and Compartmental Disorders
- Diagnosis and treatment of tuberculosis
- Mesenchymal stem cell research
- Pancreatic function and diabetes
- Pneumocystis jirovecii pneumonia detection and treatment
- Neuroscience and Neuropharmacology Research
- Immune cells in cancer
- Diet, Metabolism, and Disease
- Cancer, Hypoxia, and Metabolism
- COVID-19 epidemiological studies
- Cancer-related molecular mechanisms research
- Surgical Sutures and Adhesives
- Child and Adolescent Psychosocial and Emotional Development
- Pneumonia and Respiratory Infections
- Hemostasis and retained surgical items
- Electrolyte and hormonal disorders
- Tissue Engineering and Regenerative Medicine
- Acupuncture Treatment Research Studies
- Electroconvulsive Therapy Studies
- Vaccine Coverage and Hesitancy
Tianjin University
2021-2025
Wenzhou University
2023-2025
Fujian University of Traditional Chinese Medicine
2023-2024
Army Medical University
2015-2023
Xinqiao Hospital
2015-2023
Songjiang District Central Hospital
2014-2023
North Sichuan Medical University
2023
Hebei North University
2023
Heze University
2023
Fudan University
2021
ABSTRACT BACKGROUND The ongoing worldwide outbreak of the 2019-nCoV is markedly similar to severe acute respiratory syndrome (SARS) 17 years ago. During 2002-2003 SARS outbreak, healthcare workers formed a special population patients. Although virus-specific IgG play important roles in virus neutralization and prevention against future infection, limited information available regarding long term persistence after infection with SARS-like coronavirus. METHODS A long-term prospective cohort...
Small-diameter vascular grafts (SDVGs) are urgently required for clinical applications. Constructing mimicking the defining features of native arteries is a promising strategy. Here, we constructed tri-layered graft with artery decellularized extracellular matrix (dECM) component arteries. The porcine thoracic aorta was and milled into dECM powders from differential layers. intima media were blended poly (L-lactide-co-caprolactone) (PLCL) as inner middle layers electrospun grafts,...
Dysregulation of hepatic glucose production (HGP) serves as a major underlying mechanism for the pathogenesis type 2 diabetes. The pancreatic hormone glucagon increases and insulin suppresses HGP, controlling blood homeostasis. forkhead transcription factor Foxo1 promotes HGP through increasing expression genes encoding rate-limiting enzymes responsible gluconeogenesis. We previously established that by Akt-mediated phosphorylation at Ser256 in human hepatocytes. In this study, we found...
To evaluate the effect of dapagliflozin on liver fat content (LFC) and pancreatic (PFC).84 patients with type 2 diabetes (T2D) non-alcoholic fatty disease (NAFLD) were randomly assigned to receive either (n = 42) or serve as controls 42). The primary endpoint is changes in LFC PFC using magnetic resonance imaging estimated proton density fraction. Secondary outcomes include fibrosis index, inflammatory cytokine levels, enzyme levels.At week 24, group significantly reduced (P < 0.001) 0.033)...
Background: Most studies on mental health problems caused by COVID-19 crisis in children were limited to the period of home quarantine. It remained unclear what adverse impact psychosocial stressors school reopening, as well transitions daily activities and social interactions had children. Methods: A total 6400 students primary schools enrolled a cross-sectional study conducted East China, between June 26 July 6, 2020, when reopened. Children's status was assessed parent version Strengths...
Noncompressible hemorrhage is a major cause of posttrauma death and occupies the leading position among potentially preventable trauma-associated deaths. Recently, multiple studies have shown that strongly adhesive materials can serve as hemostatic for noncompressible hemorrhage. However, risk severe tissue adhesion limits use hydrogels materials. Here, we report promising material system comprising an injectable sol liquid spray potential solution. Injectable mainly composed gelatin (GEL)...
With improved tuberculosis (TB) control programs, the incidence of TB in China declined dramatically over past few decades, but recently rate decrease has slowed, especially large cities such as Shanghai. To help formulate strategies to further reduce incidence, we performed a 10-year study Songjiang, district Shanghai, delineate characteristics, transmission patterns, and dynamic changes local burden.We conducted population-based culture-positive pulmonary patients diagnosed Songjiang...
Abstract The transcription factor forkhead box O1 (FoxO1) is a key mediator in the insulin signaling pathway and controls multiple physiological functions, including hepatic glucose production (HGP) pancreatic β-cell function. We previously demonstrated that S256 human FOXO1 (FOXO1-S256), equivalent to S253 mouse FoxO1 (FoxO1-S253), phosphorylation site mediating effect of as target protein kinase B on suppression activity expression genes responsible for gluconeogenesis. Here, we...
Inflammation and hypoxia are involved in numerous cancer progressions. Reportedly, the toll-like receptor 4 (TLR4)/nuclear factor kappa B (NF-κB) pathway hypoxia-inducible factor-1α (HIF-1α) activated closely related to chemoresistance poor prognosis of epithelial ovarian (EOC). However, potential correlation between TLR4/NF-κB HIF-1α remains largely unknown EOC. In our study, possible positive among TLR4, NF-κB, proteins was investigated EOC tissues. Our vitro results demonstrated that LPS...
Introduction: It is well-known that maize and wheat are main food crops in the world. Thus, promoting high quality abundant guarantees development of grain industry, which needed to support world hunger. Weeds seriously affect growing environment maize, wheat, their seedlings, resulting low crop yields poor seedling quality. This paper focuses on identification seedlings field weeds using deep learning. Methods: Maize research objects. A weed model based UNet network ViT classification...
The fitness of multidrug-resistant tuberculosis (MDR-TB) is thought to be an important determinant a strain's ability transmitted. Studies in the laboratory have demonstrated that MDR-TB strains reduced but relative transmissibility versus drug-susceptible (DS) TB human populations remains unresolved. We used data on genomic clustering from our previous molecular epidemiological study Songjiang (2011-2020) and Wusheng (2009-2020), China, compare DS-TB. Genomic clusters were defined with...
Electroacupuncture (EA) is a complementary and alternative therapy which has shown protective effects on vascular cognitive impairment (VCI). However, the underlying mechanisms are not entirely understood.Rat models of VCI were established with cerebral ischemia using occlusion middle artery or bilateral common carotid artery. The brain structure function imaging measured through animal MRI. miRNA expression was detected by chip qPCR. Synaptic functional plasticity electrophysiological...
Purpose: Digital interventions for adolescent mental health are emerging in high-income countries, but have faced challenges and scarce China. This study investigated the effect of a short video-based intervention on depressive symptoms Chinese adolescents. Methods: A three-arm cluster randomized controlled trial was conducted four junior high schools Shanghai from December 2020 to 2021 with measurement at baseline, 6 months after entry, 12 months. Outcomes were collected by self-completed...
(1) Background: It is important to improve vaccination strategies and immunization programs achieve herd immunity infectious diseases. (2) Methods: To assess the acceptance of COVID-19 vaccination, we conducted face-to-face surveys online in Shanghai, Zhejiang, Qinghai provinces. A fixed-effect model a random effects were used analyze factors associated with vaccination. (3) Findings: We initially recruited 3173 participants, 3172 participants completed full questionnaire (the response rate...
Metformin is the first-line pharmacotherapy for type 2 diabetes mellitus (T2D). exerts its glucose-lowering effect primarily through decreasing hepatic glucose production (HGP). However, precise molecular mechanisms of metformin remain unclear due to supra-pharmacological concentration used in study. Here, we investigated role Foxo1 action control homeostasis and mechanism via transcription factor mice, as well clinical relevance with co-treatment aspirin. We showed that inhibits HGP blood a...
This paper emphasizes the key role of policy in development agricultural services outsourcing. In this paper, a theoretical framework is constructed to analyze government policies on service outsourcing under assumption separability production processes. The article constructs quasi-natural experiment using China-targeted poverty alleviation program and nationally representative microdata, PSM-DID model chosen estimate effects. We also discuss regional heterogeneity, aiming identify ways...