A5100656681- Dialysis and Renal Disease Management
- Ion Transport and Channel Regulation
- Heme Oxygenase-1 and Carbon Monoxide
- Renal Diseases and Glomerulopathies
- Ion Channels and Receptors
- MicroRNA in disease regulation
- Ion channel regulation and function
- Hemoglobin structure and function
- Health Systems, Economic Evaluations, Quality of Life
- Magnesium in Health and Disease
- Parathyroid Disorders and Treatments
- Cardiovascular Function and Risk Factors
- Natural product bioactivities and synthesis
- Pancreatic function and diabetes
- Porphyrin Metabolism and Disorders
- Cardiac Valve Diseases and Treatments
- Autophagy in Disease and Therapy
- Genomic variations and chromosomal abnormalities
- Peroxisome Proliferator-Activated Receptors
- Traditional Chinese Medicine Studies
- Diabetes and associated disorders
- Bone and Dental Protein Studies
- Muscle and Compartmental Disorders
- Fluoride Effects and Removal
- Cardiovascular Health and Risk Factors
Harbin Medical University
2014-2025
Shanghai Sixth People's Hospital
2025
Shanghai Jiao Tong University
2025
Peking University Shenzhen Hospital
2025
Chinese Academy of Medical Sciences & Peking Union Medical College
2024
Second Affiliated Hospital of Harbin Medical University
2013-2023
Army Medical University
2010-2021
Xinqiao Hospital
2021
Peking University People's Hospital
2019
Peking University
2019
Osteoarthritis is a degenerative disease that often causes patients to experience joint pain and deformity. It has been demonstrated tumor necrosis factor (TNF)-α associated with the progression of osteoarthritis; however, best our knowledge, mechanisms by which TNF-α simulates osteoarthritis signaling pathway(s) it influences remain unknown. Therefore, aim present study was investigate therapeutic effects inhibitor in an iodoacetate-induced rat model identify its potential action. Western...
Objectives We aimed to explore the impacts of individual and environmental socioeconomic status (SES) on outcome peritoneal dialysis (PD) in regions with significant SES disparity, through a retrospective multicenter cohort China. Methods Overall, 2,171 incident patients from seven PD centers were included. Individual was evaluated yearly household income per person education level. Environmental represented by regional gross domestic product (GDP) capita medical resources. Undeveloped...
Calcium-sensing receptor (CaSR) has been demonstrated to be present in several tissues and cells unrelated systemic calcium homeostasis, where it regulates a series of diverse cellular functions. A previous study indicated that CaSR is expressed mouse glomerular mesangial (MCs), stimulation induces cell proliferation. However, the signaling cascades initiated by activation MCs are currently unknown. In this study, our data demonstrate mRNA protein human line. Activating with high...
Aims To investigate whether uric acid (UA) is an independent predictor of cardiovascular (CV) and all-cause mortality in peritoneal dialysis (PD) patients after controlling for recognized CV risk factors. Methods A total 2264 on chronic PD were collected from seven centers affiliated with the Socioeconomic Status Outcome Peritoneal Dialysis (SSOP) Study. All demographic laboratory data recorded at baseline. Multivariate Cox regression was used to calculate hazard ratio (HR) adjustments...
The American Heart Association recently published an updated algorithm for quantitative assessments of cardiovascular health (CVH) metrics, namely Life's Essential 8 (LE8). This study aimed to compare the predictive value between Simple 7 (LS7) and LE8 predict likelihood major adverse cardiac events (MACEs) in patients undergoing percutaneous coronary intervention (PCI) determine utility predicting CVH outcomes. A total 339 with acute syndrome (ACS) who had undergone PCI were enrolled assess...
The crystal structure of a heme oxygenase (HO) HugZ from Helicobacter pylori complexed with has been solved and refined at 1.8 Å resolution. is part the iron acquisition mechanism H. pylori, major pathogen human gastroenteric diseases. It required for adaptive colonization in hosts. Here, we report that distinct all other characterized HOs. exists as dimer solution crystals, adopts split-barrel fold often found FMN-binding proteins but not observed hemoproteins. located intermonomer...
Fluorine is a strong oxidizing element and excessive intake can have harmful effects, particularly on the body's calcified tissues. Recent studies demonstrated link between miRNA fluorosis. This study aimed to evaluate time-dose-effect relationship of miR-200c-3p in plasma, urine cartilage rats with drinking water fluorosis, explore its potential as biomarker. Analyses were conducted using Generalised linear models, Restricted cubic spline, Spearman correlation analysis, Receiver operating...
Diabetic peripheral neuropathy (DPN), a common disorder in diabetes, is associated with severe microenvironment imbalance due to immunometabolic stress. However, the underlying mechanistic drivers remain unclear. Here, we generate single-cell atlas of human nerves and identify cell-specific transcriptional changes DPN as well aberrant amplification mast cells. Using streptozotocin-induced mouse diabetes models, further find that glucose uptake mediated by GLUT3 high-glucose (HG) diabetic...
Thyroid cancer is the most common malignant tumor in endocrine system. A significant correlation has been established between elevated CD47 expression and progression of thyroid carcinoma. This study aims to evaluate diagnostic potential immuno-positron emission tomography (immunoPET) utilizing CD47-targeting nanobodies models. Immunohistochemistry (IHC) was employed patients with cancer, as well anaplastic carcinoma (ATC) xenograft (OCUT-2C) differentiated (DTC) tumors (TPC-1 BCPAP). Two...
Objective High-throughput sequencing based on copy number variation (CNV-seq) is commonly used to detect chromosomal abnormalities including aneuploidy. This study provides evidence for the prevalence of in target populations. Methods A total 160 samples, 83 high-risk pregnancies, 37 spontaneous abortions, and 40 suspected genetic disorders, were analyzed by CNV-seq. Relationships between incidence these risk factors (e.g. advanced maternal age, abnormal pregnancy history, family history...
Abstract To identify the factors associated with serum total bilirubin (STB) and determine whether STB is independently diabetic retinopathy (DR) or kidney disease (DKD), 1,665 Chinese patients type 2 diabetes (T2DM) (248 outpatients newly diagnosed T2DM [NDM] 1,417 inpatients previously [PDM]) were studied. Clinical biochemical information was collected, a single nucleotide polymorphism (rs6704078) of UGT1A1 gene genotyped in 1,059 individuals. Multiple linear regression showed that...
TOB1, a member of the BTG/TOB protein family, inhibits tumor cell proliferation. We previously observed down-regulation and phosphorylation TOB1 in gastric cancer (GC). Here, we examined subcellular distribution clinical significance expression GC. Immunohistochemical analysis 341 primary GC corresponding normal tissue samples demonstrated that nuclear was lower than (80.4% vs. 92.4%), decreased correlated with high TNM stage. By contrast, higher (66.0% 36.4%), associated poorly...
Recent studies provided compelling evidence that stimulation of the calcium sensing receptor (CaSR) exerts direct renoprotective action at glomerular podocyte level. This protective may be attributed to RhoA-dependent stabilization actin cytoskeleton. However, underlying mechanisms remain unclear.In present study, an immortalized human cell line was used. Fluo-3 fluorescence utilized determine intracellular Ca2+ concentration ([Ca2+]i), and western blotting used measure canonical transient...
l-carnitine is a natural compound that indispensable for energy metabolism in mammals. The efficiency and safety of improving sperm activity, enhancing epididymal function treating male infertility has been widely acknowledged by clinicians. CircRNAs can regulate gene expression at the transcriptional or post-transcriptional level serving as molecular sponge miRNAs with miRNA response elements. However, detailed mechanism linking miRNA, circRNA asthenospermia remains unclear. present study...
Karyotyping is the gold standard cytogenetic method for detection of ring chromosomes. In this study we report molecular characterization a novel 6 (r6) chromosome in six-year-old girl with severe mental retardation, congenital heart disease and craniofacial abnormalities.Cytogenetic analysis was performed by conventional karyotyping. Molecular genetic analyses were using high-resolution microarray (CMA) next generation sequencing (NGS). OMIM, UCSC PubMed used as reference databases to...
Metformin is the first-line pharmacotherapy for type 2 diabetes mellitus (T2D). exerts its glucose-lowering effect primarily through decreasing hepatic glucose production (HGP). However, precise molecular mechanisms of metformin remain unclear due to supra-pharmacological concentration used in study. Here, we investigated role Foxo1 action control homeostasis and mechanism via transcription factor mice, as well clinical relevance with co-treatment aspirin. We showed that inhibits HGP blood a...
Intracellular Ca2+ signaling plays an important role in the regulation of autophagy. However, very little is known about influx, which induced by plasma membrane channels. Our previous study showed that transient receptor potential canonical channel-6 (TRPC6), a major influx pathway podocytes, was activated hypoxia. Here, we investigated whether TRPC6 involved hypoxia-induced autophagy cultured human podocytes.In present study, immortalized podocyte cell line used. Fluo-3 fluorescence...
To investigate whether education level of family members predicts all-cause and cardiovascular death initial-episode peritonitis in patients on peritoneal dialysis (PD).