A5101424352- Reproductive Biology and Fertility
- Reproductive System and Pregnancy
- Ovarian function and disorders
- Endometriosis Research and Treatment
- Circular RNAs in diseases
- Assisted Reproductive Technology and Twin Pregnancy
- Prenatal Screening and Diagnostics
- MicroRNA in disease regulation
- Pregnancy and preeclampsia studies
- Apelin-related biomedical research
- Cancer-related molecular mechanisms research
- Sperm and Testicular Function
- Reproductive Health and Technologies
- RNA modifications and cancer
- Appendicitis Diagnosis and Management
- COVID-19 Impact on Reproduction
- Extracellular vesicles in disease
- Air Quality and Health Impacts
- Plant and Fungal Interactions Research
- Preterm Birth and Chorioamnionitis
- Genetic Syndromes and Imprinting
- Ferroptosis and cancer prognosis
- Gestational Diabetes Research and Management
- Calpain Protease Function and Regulation
- Electron Spin Resonance Studies
First Hospital of Lanzhou University
2017-2025
Lanzhou University
2017-2025
Guangxi University
2025
State Key Laboratory For Conservation and Utilization of Subtropical Agro-Bioresources
2025
University of Science and Technology of China
2020
Lanzhou University Second Hospital
2017-2019
Fort Valley State University
2012
Carbapenem-resistant hypervirulent Klebsiella pneumoniae (CR-hvKP) have been increasingly reported in China. Here, a multicentre, longitudinal surveillance study on CR-hvKP is described.We retrospectively investigated carbapenem-resistant K. (CRKP) 56 centres across China during 2015-17 and screened the virulence genes (iucA, iroN, rmpA rmpA2) for presence of plasmids. Hypermucoviscosity, serum killing Galleria mellonella lethality experiments were conducted to identify among strains with...
BackgroundReal-time reverse transcription-PCR (rRT-PCR) has been the most effective and widely implemented diagnostic technology since beginning of COVID-19 pandemic. However, fuzzy rRT-PCR readouts with high Ct values are frequently encountered, resulting in uncertainty diagnosis.MethodsA Specific Enhancer for PCR-amplified Nucleic Acid (SENA) was developed based on Cas12a trans-cleavage activity, which is specifically triggered by amplicons SARS-CoV-2 Orf1ab (O) N fragments. SENA first...
CircRNAs play an important role in regulating gene expression and the specific of circRNAs pathogenesis repeated implantation failure remains unclear. The aim this study is to assess differentially expressed patients with failure.We screened circRNA profiles endometrial biopsies taken from six women control group using microarray. Bioinformatic analyses were applied these circRNAs. Furthermore, quantitative reverse transcription polymerase chain reaction (qRT-PCR) was performed confirm...
ABSTRACT Calnexin, a calcium‐binding protein, promotes correct protein folding and prevents incompletely folded glycopolypeptides from premature oxidation degradation. Cryphonectria parasitica , an ascomycete fungus responsible for chestnut blight, poses significant threat to the forest or orchards worldwide. Although various aspects of calnexin have been investigated, little is known about impact fungal viruses. CpCne was identified characterized in this study, encoding C. . Strains with...
Abstract Objective To investigate the severity and risk factors of menopausal symptoms in middle-aged women Gansu Province China. Methods In this cross-sectional study, a total 7319 (aged 40–55 years) attended health survey China were enrolled. Information on demographics, status, reproductive history, history chronic diseases was collected via structured questionnaire. Severity symptom evaluated by Modified Kupperman Menopausal Index. Ordinal logistic regression model applied to explore its...
Limb‑girdle muscular dystrophies are a group of extremely heterogenous neuromuscular disorders that manifest with gradual and progressive weakness both proximal distal muscles. Autosomal dominant limb‑girdle dystrophy (LGMDD4) or calpainopathy is very rare form myopathy characterized by atrophy muscles variable age onset. LGMDD4 caused germline heterozygous mutations the calpain 3 (<em>CAPN3</em>) gene. Patients often show extreme phenotypic heterogeneity; however, most patients present gait...
l-carnitine is a natural compound that indispensable for energy metabolism in mammals. The efficiency and safety of improving sperm activity, enhancing epididymal function treating male infertility has been widely acknowledged by clinicians. CircRNAs can regulate gene expression at the transcriptional or post-transcriptional level serving as molecular sponge miRNAs with miRNA response elements. However, detailed mechanism linking miRNA, circRNA asthenospermia remains unclear. present study...
Nonobstructive azoospermia (NOA), which is considered the most severe form of male infertility, has placed a heavy burden on families and society. As vital regulators transcriptional post-transcriptional levels, Noncoding RNAs (ncRNAs) are closely related to all pathophysiological processes involved in infertility males, especially spermatogenesis. Our study explored expression levels circ_0049356 both whole blood seminal plasma samples idiopathic NOA patients via quantitative real-time PCR....
The purpose of this study was to evaluate the effectiveness next-generation sequencing (NGS)-based preimplantation genetic testing (PGT) for balanced translocation carriers identify normal/balanced blastocysts and measure pregnancy outcomes following euploid embryo transfer. We enrolled 75 couples with a who underwent 83 PGT cycles (58 reciprocal translocations 25 Robertsonian translocations) 388 were diagnosed. Moreover, we transferred single through frozen transfer calculated biochemical...
Human chorionic gonadotropin (hCG) might affect endometrial receptivity, exerting integral roles in embryo implantation. This study explored the action of hCG receptivity via miR-126-3p/PIK3R2/PI3K/Akt/eNOS axis. The implantation dysfunction (EID) mouse models were established by administrating mifepristone and human epithelial cells (EECs) used for vivo experiments, both followed treatment. Expression level CD105 protein levels cadherin CD144 CD146 mice determined immunohistochemistry...
Abstract Background Oocytes have a lot of maternal RNAs and proteins, which are used by the early embryo before zygotic genome activation. Transducin‐like enhancer split 6 (TLE6) is component subcortical complex plays critical role in embryonic development. Methods The patient had been diagnosed with primary infertility for years undergone multiple failed vitro fertilization (IVF)/intracytoplasmic sperm injection (ICSI) cycles. Genomic DNA samples were extracted from her parents’ peripheral...
Unexplained recurrent pregnancy loss (URPL) is a clinical dilemma in reproductive fields. Its diagnosis mainly exclusionary after extensive examination, and some of the patients may still face risk miscarriage.
Premature ovarian insufficiency is characterized by reduced function in a young woman, resulting an earlier menopause compared with women normal function. It term that reflects the variable nature of condition and substantially less emotive than formerly used ‘premature failure’, which suggested single event time. Tripterygium glycosides can damage cause infertility. This case report describes 33-year-old female patient (gravida 0, parity 0) who presented premature after being treated...
This study aimed to uncover the specific role of micro RNA-16 (miR-16) in granulosa cell function polycystic ovarian syndrome (PCOS). After sample collection, expression levels miR-16 and Apelin13 cells PCOS patients controls were determined. Subsequently, mimic, inhibitor, pcDNA3.1-Apelin13, sh-Apelin13, their corresponding negative transfected into lines (KGN SVOG) monitor alterations expression, Apelin13, PI3K/Akt signalling pathway-related proteins (p-Akt Akt). MTT assay was used detect...
Inadequate endometrial receptivity is a key factor affecting the successful implantation of embryos. Recombinant human granulocyte colony stimulating (rhG-CSF) can increase thickness and improve outcomes assisted reproductive technologies (ARTs). In this preliminary study, function possible molecular mechanisms recombinant which affects in Embryonic Stem Cells (hESCs) were investigated. The cell viability stromal cells treated with rhG-CSF 0.5 ng/ml for 24 h was significantly increased....
To study the pharmacological mechanism of procyanidin B2 (PCB2) on chronic myeloid leukemia (CML) by integrating network methods systematically. Firstly, potential target genes PCB2 were predicted database and analysis platform (TCMSP Pharmmapper). Meanwhile, relevant CML collected from GeneCards DisGene. Pooled data to screen for common genes. Furthermore, above intersection imported into String website construct a protein-protein interaction (PPI) network, Gene Ontology (GO) functional...
The 25-hydroxyvitamin D3 (25 (OH) D3) is crucial for follicular development. This study aimed to investigate the relationship between level of 25 in endometriosis patients, pregnancy outcomes vitro fertilization (IVF), and underlying mechanism.The levels serum Fluid (FF) samples were detected using enzyme-linked immunosorbent assay (ELISA). Clinical features patients also compared deficient group (< 20 ug/ml) adequate (≥ ug/ml). effects on proliferation cell cycle human ovarian granulosa...