A5100355086- Metabolism, Diabetes, and Cancer
- FOXO transcription factor regulation
- Muscle Physiology and Disorders
- Phytochemicals and Antioxidant Activities
- Gut microbiota and health
- Pancreatic function and diabetes
- Plant Stress Responses and Tolerance
- Muscle activation and electromyography studies
- Cardiomyopathy and Myosin Studies
- Mitochondrial Function and Pathology
- Natural Antidiabetic Agents Studies
- Diet, Metabolism, and Disease
- Retinal Development and Disorders
- Anesthesia and Neurotoxicity Research
- Liver Disease Diagnosis and Treatment
- RNA Research and Splicing
- Medicinal Plants and Bioactive Compounds
- Plant Gene Expression Analysis
- Neurological Disease Mechanisms and Treatments
- RNA modifications and cancer
- Metabolomics and Mass Spectrometry Studies
- Plant Molecular Biology Research
- Diet and metabolism studies
- Food Quality and Safety Studies
- Chromatography in Natural Products
Hunan Academy of Agricultural Sciences
2023-2025
Capital Normal University
2025
Hunan Agricultural Products (China)
2024-2025
Michigan State University
2007-2024
First Affiliated Hospital of Xi'an Jiaotong University
2024
Texas A&M University
2018-2023
Yichun University
2022-2023
Anhui Provincial Hospital
2023
First Affiliated Hospital of Anhui Medical University
2023
Anhui Medical University
2023
Premenopausal women exhibit enhanced insulin sensitivity and reduced incidence of type 2 diabetes (T2D) compared with age-matched men, but this advantage disappears after menopause disrupted glucose homeostasis, in part owing to a reduction circulating 17β-estradiol (E2). Fasting hyperglycemia is hallmark T2D derived largely from dysregulation hepatic production (HGP), which Foxo1 plays central role the regulation gluconeogenesis. Here, we investigated action E2 on homeostasis male...
Injury-initiated epithelial to mesenchymal transition (EMT) depends on contextual signals from the extracellular matrix, suggesting a role for integrin signaling. Primary cells deficient in their prominent laminin receptor, α3β1, were found have markedly blunted EMT response TGF-β1. A mechanism this defect was explored α3-null reconstituted with wild-type (wt) α3 or point mutants unable engage 5 (G163A) cadherin (E-cadherin; H245A). After TGF-β1 stimulation, wt but not expressing H245A...
As a major component of green tea, (-)-epigallocatechin-3-gallate (EGCG) has attracted interest from scientists owing to its potential combat variety human diseases including abnormal glucose metabolism in obesity and diabetes. This study aims (1) evaluate the molecular mechanism EGCG starch digestion before absorption; (2) investigate link between PXR/CAR-mediated phase II homeostasis after is transported small intestine liver. suppressed hydrolysis both vitro vivo. Molecular simulation...
Abstract Photoperiodic regulation of flowering time plays a critical role in plant reproductive success and crop yield. In Arabidopsis thaliana, the expression CONSTANS (CO) gene is closely regulated by day length modulated both environmental endogenous cues for precise control over flowering. Our findings reveal that phytohormone brassinosteroid (BR) pathway represses inhibiting CO Flowering Locus T (FT). Additionally, we discovered BRASSINAZOLE RESISTANT 1 (BZR1), key transcription factor...
This study investigated the protective properties of lotus seedpod oligomeric procyanidins (LSOPC) against nonalcoholic fatty liver disease (NAFLD) and its underlying mechanism. Sprague-Dawley (SD) male rats were fed a basic diet, high-fat diet (HFD), or HFD plus 0.2 0.5% (w/w) LSOPC for 12 weeks. Administration markedly reduced serum hepatic biochemical parameters protein expression advanced glycation endproducts (AGEs). Additionally, treatment remarkably reversed increasing tendency...
Elevated sweat chloride levels, failure to thrive (FTT), and lung disease are characteristic features of cystic fibrosis (CF, OMIM #219700). Here we describe variants in CA12 encoding carbonic anhydrase XII two pedigrees exhibiting CF-like phenotypes. Exome sequencing a white American adult diagnosed with CF due elevated chloride, recurrent hyponatremia, infantile FTT identified deleterious each gene: c.908-1 G>A splice acceptor novel frameshift insertion c.859_860insACCT. In an unrelated...
The maximum velocity of unloaded shortening (V 0 ) and the myosin heavy chain (MyHC) light (MyLC) isoform composition were determined in single fibres from soleus extensor digitorum longus (EDL) muscles male female rats 3–6 22–24 months old. In muscle, β/slow (type I MyHC) predominated both young old animals, irrespective gender. EDL, expressing type IIX MyHC or a combination IIB (IIXB) isoforms predominant rats, while individuals genders. V decreased ( P < 0.001) by 40% with age spite an...
Arterial remodeling occurs in response to mechanical and neurohumoral stimuli. We hypothesized that veins, which are not exposed higher pressures hypertension, would demonstrate less active than arteries. assessed with two standard measures of arterial remodeling: vessel morphometry the expression/function matrix metalloproteinases (MMPs). Thoracic aorta vena cava from sham normotensive DOCA-salt hypertensive rats (110 +/- 4 188 8 mmHg systolic blood pressure, respectively) were used. Wall...
Forkhead/winged helix transcription factor O-class member 1 (FoxO1) is a key mediator of insulin and glucagon signaling in control glucose homeostasis. Although epigallocatechin gallate (EGCG) has attracted interest owing to its potential combat hyperglycemic diabetes, molecular mechanisms underlying antihyperglycemic effect, particular the effect on FoxO1, poorly understand. This study aims assess impact EGCG pathway regulating metabolism. Primary hepatocytes from wild-type (WT),...
Abstract The transcription factor forkhead box O1 (FoxO1) is a key mediator in the insulin signaling pathway and controls multiple physiological functions, including hepatic glucose production (HGP) pancreatic β-cell function. We previously demonstrated that S256 human FOXO1 (FOXO1-S256), equivalent to S253 mouse FoxO1 (FoxO1-S253), phosphorylation site mediating effect of as target protein kinase B on suppression activity expression genes responsible for gluconeogenesis. Here, we...
Duodenogastric reflux (DGR) is closely associated with gastric inflammation and tumorigenesis; however, the precise mechanism unclear. Hence, we aim to clarify this molecular design an effective therapeutic strategy based on it. The present study found that DGR induced TXNIP/NLRP3 inflammasome activation triggered pyroptosis in mucosa
Metformin is the first-line pharmacotherapy for type 2 diabetes mellitus (T2D). exerts its glucose-lowering effect primarily through decreasing hepatic glucose production (HGP). However, precise molecular mechanisms of metformin remain unclear due to supra-pharmacological concentration used in study. Here, we investigated role Foxo1 action control homeostasis and mechanism via transcription factor mice, as well clinical relevance with co-treatment aspirin. We showed that inhibits HGP blood a...
Colorectal cancer (CRC) accounts for the third highest morbidity burden among malignant tumors worldwide. Previous studies investigated gut microbiome changes that occur during colorectal adenomas (CRA) progression to overt CRC, thus highlighting importance of in carcinogenesis. However, few have examined characteristics across entire spectrum, from CRC development treatment. The study used 16S ribosomal ribonucleic acid and internal transcribed spacer amplicon sequencing compare composition...