A5101886259- Advanced Optical Imaging Technologies
- Muscle Physiology and Disorders
- Cardiomyopathy and Myosin Studies
- Photonic and Optical Devices
- Artificial Intelligence in Healthcare and Education
- Photorefractive and Nonlinear Optics
- Topic Modeling
- AI in cancer detection
- Monoclonal and Polyclonal Antibodies Research
- Optical and Acousto-Optic Technologies
- Multimodal Machine Learning Applications
- Viral Infections and Vectors
- Advanced biosensing and bioanalysis techniques
- SARS-CoV-2 and COVID-19 Research
- Immunotherapy and Immune Responses
- Animal Genetics and Reproduction
- Flame retardant materials and properties
- Digital Holography and Microscopy
- Optical Polarization and Ellipsometry
- Advanced Sensor and Control Systems
- Advanced Optical Sensing Technologies
- Electrical and Bioimpedance Tomography
- Genetic Neurodegenerative Diseases
- Ethics and Social Impacts of AI
- Semiconductor Lasers and Optical Devices
Wuhan University
2023-2025
Ministry of Education of the People's Republic of China
2025
Harvard University
2024
Southeast University
2024
Hubei Normal University
2023-2024
Wuhan University of Technology
2024
Shandong University
2023
Wuhan Institute of Virology
2023
Stanford University
2022-2023
Central South University
2023
Artificial intelligence (AI) models for automatic generation of narrative radiology reports from images have the potential to enhance efficiency and reduce workload radiologists. However, evaluating correctness these requires metrics that can capture clinically pertinent differences. In this study, we investigate alignment between automated radiologists' scoring errors in report generation. We address limitations existing by proposing new metrics, RadGraph F1 RadCliQ, which demonstrate...
Abstract The integration of artificial intelligence (AI) in medical image interpretation requires effective collaboration between clinicians and AI algorithms. Although previous studies demonstrated the potential assistance improving overall clinician performance, individual impact on remains unclear. This large-scale study examined heterogeneous effects 140 radiologists across 15 chest X-ray diagnostic tasks identified predictors these effects. Surprisingly, conventional experience-based...
With the development of social economy and improvement electrification, cables wires play an important role in people’s lives industrial development. Meanwhile, large-scale laying has also made them a fire hazard that cannot be ignored land construction such as residential buildings, utility tunnels, nuclear power plants, refineries, marine systems submarines ships, airborne spacecrafts aircrafts. In this work, studies on characteristics over last decades have been reviewed. Based different...
Abstract Coupling distinct enzymatic effectors emerges as an efficient strategy for defense against phage infection in bacterial immune responses, such the widely studied nuclease and cyclase activities type III CRISPR-Cas system. However, concerted other systems are poorly understood. Here, we biochemically structurally characterize a two-component system DUF4297–HerA, demonstrating that DUF4297–HerA confers resistance by cooperatively cleaving dsDNA hydrolyzing ATP. DUF4297 alone forms...
Nipah virus (NiV) is a zoonotic emergent paramyxovirus that can cause severe encephalitis and respiratory infections in humans, with high fatality rate ranging from 40% to 75%. Currently, there are no approved human vaccines or antiviral drugs against NiV. Here, we designed ferritin-based self-assembling nanoparticle displaying the NiV G head domain on surface (NiV G-ferritin) assessed immune responses elicited by soluble sG) G-ferritin. Immunization G-ferritin sG conferred complete...
Abstract The rapid spread of monkeypox in multiple countries has resulted a global public health threat and caused international concerns since May 2022. Poxvirus encoded M2 protein is member the poxvirus immune evasion family plays roles host immunomodulation via regulation innate response mediated by NF-κB pathway adaptive B7 ligands. However, interaction virus (MPXV) with ligands structural insight into poxviral function have remained elusive. Here we reveal that MPXV M2, co-existing as...
The maximum velocity of unloaded shortening (V 0 ) and the myosin heavy chain (MyHC) light (MyLC) isoform composition were determined in single fibres from soleus extensor digitorum longus (EDL) muscles male female rats 3–6 22–24 months old. In muscle, β/slow (type I MyHC) predominated both young old animals, irrespective gender. EDL, expressing type IIX MyHC or a combination IIB (IIXB) isoforms predominant rats, while individuals genders. V decreased ( P < 0.001) by 40% with age spite an...
Abstract Coronavirus disease 2019 (COVID-19) was first reported three years ago, when a group of individuals were infected with the original SARS-CoV-2 strain, based on which vaccines developed. Here, we develop six human monoclonal antibodies (mAbs) from two elite convalescents in Wuhan and show that these mAbs recognize diverse epitopes receptor binding domain (RBD) can inhibit infection strain variants concern (VOCs) to varying degrees, including Omicron strains XBB XBB.1.5. Of mAbs, most...
Severe fever with thrombocytopenia syndrome virus (SFTSV) is an emerging bunyavirus that causes severe viral hemorrhagic and a fatality rate of up to 30%. No licensed vaccines or therapeutics are currently available for humans. Here, we develop seven monoclonal antibodies (mAbs) against SFTSV surface glycoprotein Gn. Mechanistic studies show three neutralizing mAbs (S2A5, S1G3, S1H7) block multiple steps during infection, including attachment membrane fusion, whereas another mAb (B1G11)...
Aneuploidy is a hallmark of aggressive malignancies associated with therapeutic resistance and poor survival. Measuring aneuploidy requires expensive specialized techniques that are not clinically applicable. Deep learning analysis routine histopathology slides has revealed associations genetic mutations. However, existing studies focus on image patches or tiles, there no prior work predicts using single-cell analysis. Here, we present heterogeneity-aware transformer-guided deep framework to...
The rev-erbAalpha orphan protein belongs to the steroid nuclear receptor superfamily. No ligand has been identified for this protein, and little is known of its function in development or physiology. In study, we focus on 1) distribution adult fast- slow-twitch skeletal muscles muscle fibers 2) how influences myosin heavy chain (MyHC) isoform expression mice heterozygous (+/-) homozygous (-/-) a null allele. fast-twitch extensor digitorum longus muscle, was linked fiber type; however, MyHC...
Ovocleidin (OC-116), a protein identified in eggshell matrix, was found to be expressed avian growth plate chondrocytes. Because OC-116 has been reported member of family related phosphoprotein genes clustered on chromosome 4, we expanded our search other skeletal tissues. Using Western blotting, the matrix chick cortical bone and laying hen medullary as well hypertrophic chondrocyte lysates. Furthermore, members this (bone sialoprotein, dental protein-1, osteopontin) were also present...
Abstract The application of AI to medical image interpretation tasks has largely been limited the identification a handful individual pathologies. In contrast, generation complete narrative radiology reports more closely matches how radiologists communicate diagnostic information in clinical workflows. Recent progress artificial intelligence (AI) on vision-language enabled possibility generating high-quality from images. Automated metrics evaluate quality generated attempt capture overlap...
The method of archival storage color films utilizing a spatial encoding process and white light image retrieval technique is described. This offers several advantages as compared with all the other existing techniques: It employs source for decoding processes, so that coherent artifact noise can be avoided. Since does not utilize slit aperture narrow filter, reproduced causes no marginal loss in resolution. volume by this also reduced to one-third needed traditional technique. advantage...
Machine learning algorithms now exceed human performance on several predictive tasks, generating concerns about widespread job displacement. However, supervised approaches rely large amounts of high-quality labeled data and are designed for specific tasks. Thus, humans may be required a number each which is not commonly encountered—the long tail—because can make predictions broader range outcomes with exposure to much less data. We show that self-supervised algorithm chest X-rays, does...
The effects of 4 weeks thyroid hormone (3,5,3′‐triiodothyronine, T3) treatment on the expression myosin heavy chain (MyHC) isoforms were examined in young (3–6 months) and old (20–24 female rats, compared with those age‐matched male rats (Larsson et al. 1995). In control ageing was associated a type IIA to I MyHC isoform switching slow‐twitch soleus IIB IIX fast‐twitch extensor digitorum longus muscle (EDL). Gender‐ muscle‐specific differences observed regulation by T3. soleus, dramatic...