A5028174364- Advanced Numerical Methods in Computational Mathematics
- Numerical methods in engineering
- Electromagnetic Simulation and Numerical Methods
- Polynomial and algebraic computation
- Advanced Mathematical Modeling in Engineering
- Differential Equations and Numerical Methods
- CRISPR and Genetic Engineering
- Commutative Algebra and Its Applications
- Algebraic Geometry and Number Theory
- Numerical methods for differential equations
- Advanced Differential Equations and Dynamical Systems
- RNA and protein synthesis mechanisms
- Advanced biosensing and bioanalysis techniques
- Computational Fluid Dynamics and Aerodynamics
- Probabilistic and Robust Engineering Design
- Advanced Numerical Analysis Techniques
- Mathematics and Applications
- Head and Neck Cancer Studies
- Model Reduction and Neural Networks
- Stochastic processes and financial applications
- Capital Investment and Risk Analysis
- Viral Infections and Immunology Research
- RNA Interference and Gene Delivery
- Head and Neck Surgical Oncology
- History and Theory of Mathematics
Eye & ENT Hospital of Fudan University
2022-2025
Tianjin Medical University
2021-2025
Fudan University
2022-2025
Chinese Academy of Sciences
2022-2025
Changchun Institute of Applied Chemistry
2022-2025
University of Arkansas at Little Rock
2015-2024
Chinese PLA General Hospital
2018-2024
Henan University of Economic and Law
2023
Nanjing Tech University
2023
Jilin University
1991-2023
Nicotinamide adenine dinucleotide (NAD+) is a central metabolite in cellular processes. Depletion of NAD+ has been demonstrated to be prevalent theme both prokaryotic and eukaryotic immune responses. Short Argonaute proteins (Agos) are associated with NADase domain-containing (TIR-APAZ or SIR2-APAZ) encoded the same operon. They confer immunity against mobile genetic elements, such as bacteriophages plasmids, by inducing depletion upon recognition target nucleic acids. However, molecular...
Abstract The Silent Information Regulator 2 (SIR2) protein is widely implicated in antiviral response by depleting the cellular metabolite NAD + . defense-associated sirtuin (DSR2) effector, a SIR2 domain-containing protein, protects bacteria from phage infection , while an anti-DSR2 (DSR anti-defense 1, DSAD1) employed some phages to evade this host defense. NADase activity of DSR2 unleashed recognizing tail tube (TTP). However, activation and inhibition mechanisms are unclear. Here, we...
"A Simple Proof of Descartes's Rule Signs." The American Mathematical Monthly, 111(6), pp. 525–526
Nasopharyngeal carcinoma (NPC) has a 10–15% recurrence rate, while no long term or durable treatment options are currently available. Single-cell profiling in recurrent NPC (rNPC) may aid designing effective anticancer therapies, including immunotherapies. For the first time, we profiled transcriptomes of ∼60,000 cells from four primary and two rNPC cases to provide deeper insights into dynamic changes within radiation fields. Heterogeneity both immune (T, natural killer, B, myeloid cells)...
The presence of level IV/V metastasis is a significant prognostic factor for patients with oral and oropharyngeal cancer, while IV lymphadenopathy defines the N3 stage in nasopharyngeal carcinoma. However, current staging system hypopharyngeal squamous cell carcinoma (HPSCC) does not consider location involved nodes. To evaluate risk factors impact HPSCC. analysis included 2740 HPSCC from SEER (Surveillance, Epidemiology, End Results) database, followed by validated study on 232...
Despite the substantial reduction in mortality rates of nasopharyngeal carcinoma (NPC), metastasis remains primary cause death NPC cases. To explore metastasis-related proteins, we conducted proteomic and phosphoproteomic analyses three cell lines: SUNE1 its subclones, 5–8F (high metastatic potential) 6–10B (low potential). Using TMT-based quantification, identified 1231, 1524, 166 differentially regulated proteins (DRPs), as well 177, 270, 20 phosphoproteins (DRpPs) 5–8F/SUNE1, 6–10B/SUNE1...
Pressure‐sensitive adhesives (PSAs) are polymers with tunable viscoelastic properties, primarily determined by the structural configuration of their polymer chains. In this study, we report development a CO2‐based poly(carbonate‐ether) for use in PSAs applications, synthesized via copolymerization CO2 and propylene oxide. The properties resulting can be precisely modulated varying its molecular weight (Mn) carbonate unit (CU) content, yielding excellent comprehensive performance without need...
The root count developed by Bernshtein, Kushnirenko and Khovanskii only counts the number of isolated zeros a polynomial system in algebraic torus $(\mathbf {C}^*)^n$. In this paper, we modify bound slightly so that it $\mathbf {C}^n$. Our is, apparently, significantly sharper than recent found Rojas many cases easier to compute. As consequence our result, Huber-Sturmfels homotopy for finding all {C}^*)^n$ can be modified obtain
Mobile genetic elements such as phages and plasmids have evolved anti-CRISPR proteins (Acrs) to suppress CRISPR-Cas adaptive immune systems. Recently, several phage non-phage derived Acrs including AcrIIA17 AcrIIA18 been reported inhibit Cas9 through modulation of sgRNA. Here, we show that inactivate distinct mechanisms. inhibits activity interference with Cas9-sgRNA binary complex formation. In contrast, induces the truncation sgRNA in a Cas9-dependent manner, generating shortened incapable...
Abstract The type III-E CRISPR–Cas systems are newly identified adaptive immune in prokaryotes that use a single Cas7–11 protein to specifically cleave target RNA. could associate with Csx29, putative caspase-like encoded by the gene frequently found loci, suggesting functional linkage between RNase and protease activities systems. Here, we demonstrated RNA recognition would stimulate proteolytic activity of Csx30 is endogenous substrate. More interestingly, while cognate activate...
Background Laryngeal squamous cell carcinoma (LSCC) is one of the world’s most common head and neck cancer. However, immune infiltration phenotypes LSCC have not been well investigated. Methods The multi-omics data were obtained from TCGA (n=111) GEO (n=57) datasets. infiltrations 24 populations calculated using GSVA method. Then samples with different infiltrating patterns clustered, differences Results Patients clustered into high-infiltration low-infiltration groups. scores cells higher...
This article concerns shape regularity conditions on arbitrarily shaped polygonal/polyhedral meshes. In (J. Wang and X. Ye, A weak Galerkin mixed finite element method for second‐order elliptic problems, Math Comp 83 (2014), 2101–2126), a set of has been proposed, which allows one to prove important inequalities such as the trace inequality, inverse approximation property L 2 projection general this article, we propose simplified provides similar mesh properties. Our two advantages. First,...