A5017039148- Head and Neck Cancer Studies
- Head and Neck Surgical Oncology
- Lung Cancer Research Studies
- Ear and Head Tumors
- Salivary Gland Tumors Diagnosis and Treatment
- Immune Cell Function and Interaction
- Cancer Immunotherapy and Biomarkers
- Radiomics and Machine Learning in Medical Imaging
- Immune cells in cancer
- Lung Cancer Diagnosis and Treatment
- Cancer Genomics and Diagnostics
- Cancer Diagnosis and Treatment
- Brain Metastases and Treatment
- Viral-associated cancers and disorders
- Lung Cancer Treatments and Mutations
- Inflammatory Biomarkers in Disease Prognosis
- Cancer-related molecular mechanisms research
- Nutrition and Health in Aging
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Immune Response and Inflammation
- Genetic factors in colorectal cancer
- Management of metastatic bone disease
- Medical Research and Treatments
- Glioma Diagnosis and Treatment
- Oral health in cancer treatment
Shanghai Medical College of Fudan University
2015-2024
Shanghai Clinical Research Center
2022-2024
Fudan University Shanghai Cancer Center
2015-2024
Shanghai Institute of Hematology
2021-2024
Minhang District Central Hospital
2022
Fudan University
2011-2022
California Polytechnic State University
2005
To report long‐term results of a randomized controlled trial that compared cisplatin/fluorouracil/docetaxel (TPF) induction chemotherapy (IC) plus concurrent chemoradiotherapy (CCRT) with CCRT alone in locoregionally advanced nasopharyngeal carcinoma (NPC). Patients stage III–IVB (except T3–4 N0) NPC were randomly assigned to receive IC (n = 241) or 239). included three cycles docetaxel (60 mg/m 2 d1), cisplatin and fluorouracil (600 /d civ d1–5) every 3 weeks. from both groups received...
This study was to report the long-term outcomes and toxicities of nasopharyngeal carcinoma (NPC) treated with intensity-modulated radiation therapy (IMRT). From 2009 2010, 869 non-metastatic NPC patients IMRT were retrospectively enrolled. With a median follow-up 54.3 months, 5-year estimated local recurrence-free survival (LRFS), regional (RRFS), distant metastasis-free (DMFS), disease-free (DFS) overall (OS) 89.7%, 94.5%, 85.6%, 76.3%, 84.0%, respectively. In locally advanced NPC, gender,...
Characterization, diagnosis, and treatment of colorectal cancers (CRC) is difficult due to limited biopsy information, impracticality repeated biopsies, cancer biomarker fallibility. Circulating tumor DNA (ctDNA) has recently been investigated as a non-invasive way gain representative gene mutations in tumors, addition monitoring disease progression response treatment. We analyzed ctDNA concentrations 47 early- late-stage CRC patients using targetted sequencing approach panel that covers 50...
Abstract Locally recurrent nasopharyngeal carcinoma (rNPC) after definitive IMRT occurs in 10% of all cases and represents a distinct clinical entity that has been selectively enriched by radio-resistant cancer cells. Therefore, we report the outcomes 77 patients who had repeat salvage-IMRT for rNPC only course IMRT. Various were measured. Log-rank tests used to detect differences survival between factor-defined subgroups. Multivariable analysis was performed using Cox proportional hazard...
Nasopharyngeal carcinoma (NPC) has a 10–15% recurrence rate, while no long term or durable treatment options are currently available. Single-cell profiling in recurrent NPC (rNPC) may aid designing effective anticancer therapies, including immunotherapies. For the first time, we profiled transcriptomes of ∼60,000 cells from four primary and two rNPC cases to provide deeper insights into dynamic changes within radiation fields. Heterogeneity both immune (T, natural killer, B, myeloid cells)...
Abstract Human papillomavirus (HPV)–driven oropharyngeal carcinoma (OPSCC) is distinct from tobacco- or alcohol-associated OPSCC and has a unique immune landscape. Studies have supported the heterogeneity of T cells, accompanied by broad repertoire T-cell responses, within tumors driven HPV infection. However, phenotype function these HPV-related cells remain unclear. Using combination single-cell RNA sequencing, flow cytometry, pharmacologic inhibition, immunofluorescence staining, we...
The objective of this study was to evaluate the necessity concurrent chemotherapy in T1-2N1 nasopharyngeal carcinoma (NPC) patients treated with intensity-modulated radiation therapy (IMRT). retrospective analysis conducted using paired comparison method. We matched cases controls greedy matching algorithm 1:1 control case ratio. Controls were by factors including age, gender, T stage, and duration RT. group included received IMRT alone. In another group, (DDP 40 mg/m2/w) administrated each...
Early biomarkers of therapeutic responses can help optimize the treatment metastatic colorectal cancers (mCRC). In this prospective exploratory study, we examined serial changes plasma-circulating tumor DNA (ctDNA) in 41 mCRC patients receiving first-line chemotherapies and tested its association with outcomes according to radiological assessments. Using next-generation sequencing technologies, profiled somatic mutations 50 cancer-related genes ctDNA before each first four cycles. We...
2019 novel coronavirus disease (COVID-19) outbreaks have been occurring in China and other countries the world. To prevent further spread of disease, restrictions population flow from government measures to reduce virus transmission hospitals may lead delay diagnosis treatment patients with nasopharyngeal carcinoma (NPC).All NPC radiotherapy indications were included 20 weekdays before (group A) after B) January 31, 2020, when institute began take against COVID-19. The waiting intervals each...
Abstract Background The role of induction chemotherapy (IC) in oropharyngeal squamous cell carcinoma (OPSCC) remains controversial. Its interpretation can be confounded by heterogeneity chemosensitivity and human papillomavirus (HPV) status. This study aimed to investigate the prognostic impact IC response HPV‐positive ‐negative OPSCC. Methods Patients with OPSCC who underwent concurrent chemoradiotherapy (CCRT) were retrospectively analyzed. Radiologic ≥50% was defined as IC‐sensitive...
Abstract Patients with recurrent or metastatic head and neck cancers (R/M HNCs) are prone to developing resistance after immunotherapy. This retrospective real-world study aims investigate whether the addition of anlotinib can reverse PD-1 inhibitors (PD-1i) evaluate efficacy safety this combination in R/M HNCs. Main outcomes included objective response rate (ORR), disease control (DCR), progression-free survival (PFS), overall (OS), duration (DOR), safety. Potential biomarkers PD-L1...
Abstract Objectives/Hypothesis: Tumor burden has been confirmed as one of the important indicators in disease control after treatment for various types malignancies. This report aims to document value primary tumor volume nasopharyngeal carcinoma [gross site (GTV‐P)] predicting outcome high‐dose definitive radiation therapy. Study Design: A total 154 patients with were prospectively treated accelerated hyperfractionated radiotherapy alone a dose 78 Gy/60 fractions/6 weeks (biological...
In this study, we evaluated the prognostic values of hematological biomarkers in primary nasopharyngeal carcinoma (NPC) patients receiving definitive intensity-modulated radiotherapy (IMRT). There were 427 NPC enrolled between January 2010 and March 2013 at Fudan University Shanghai Cancer Center. Pre-treatment absolute neutrophil count (ANC), platelet (APC), lymphocyte (ALC), neutrophil-to-lymphocyte ratio (NLR) platelet-to-lymphocyte (PLR) collected as biomarkers. The Kaplan–Meier method...
Background: Weight loss during chemoradiotherapy is a major problem in patients with head and neck cancer. The aim of this study was to evaluate the effect ONS on weight, nutritional status quality life (QOL) loco-regionally advanced nasopharyngeal cancer (NPC) undergoing chemoradiotherapy.Methods: Patients locally NPC treated at tertiary hospital China prior curative were eligible for exploratory randomized study. assigned either intervention or control group based computer-generated...
To demonstrate the feasibility of deintensification regimen in light response to induction chemotherapy (IC) human papillomavirus (HPV)-associated oropharyngeal squamous cell carcinoma (OPSCC).Patients with p16+ OPSCC, T1-2/N1-3M0 (excluding T1N1M0 single and ≤3 cm lymph node) or T3-4N0-3M0 were enrolled between January 2019 July 2021. All patients received 2 cycles IC docetaxel 75 mg/m2 dL cisplatin every 3 weeks. Those major responses (≥50% decrease both primary nodes) entered cohort...
Purpose: The aim of this article is to investigate the significance pretreatment prognostic nutritional index (PNI), systemic immune-inflammation (SII), and their combination in nasopharyngeal carcinoma (NPC) patients receiving intensity-modulated radiotherapy (IMRT). Materials methods: A total 585 were included. PNI SII calculated within 2 weeks prior treatment. optimal cutoff points determined based on receiver operating characteristics curve analysis. correlation between variables was...
// Tingting Xu 1, 2 , Chunying Shen Xiaomin Ou Xiayun He Hongmei Ying Chaosu Hu 1 Department of Radiation Oncology, Fudan University Shanghai Cancer Center, Shanghai, China Medical College, Correspondence to: Hu, e-mail: hucsu62@163.com Keywords: nasopharyngeal carcinoma, locally advanced, N2–3, intensity modulated radiation therapy, adjuvant chemotherapy Received: September 08, 2015 Accepted: January 29, 2016 Published: March 02, ABSTRACT Nasopharyngeal carcinoma (NPC) patients with N2–3...
To develop and validate a quantitative complication model of temporal lobe necrosis (TLN). analyze the effect clinical dosimetric factors on TLN. In this study prediction was developed in training cohort that consisted 256 nasopharyngeal carcinoma (NPC) patients from January 2009 to December 2009. Dosimetric were extracted for building. including maximum dose, minimum mean dose covering specific volume percentage volume. Clinical include age, gender, T/N-stage, overall stage, diabetes...
Aims and background Cervical lymph node metastases of squamous cell carcinoma from an unknown primary site constitute about 5% the total head neck cancer cases. The management these patients is still a therapeutic challenge. aim present study was to analyze prognosis in series and, particular, impact different radiotherapy techniques on prognosis. Methods design Data 60 with cervical were reviewed. Nine (15.0%) received excisional biopsy. Radiotherapy delivered bilateral pharyngeal mucosa...
Abstract Background The N1 definition of 2010 UICC/AJCC staging system for nasopharyngeal carcinoma (NPC) covers quite a large range nodal pattern. objective this research is to investigate prognostic value lymph nodes related factors including involvement both cervical (CLNs) and retropharyngeal (RLNs) or not, size number in patients with NPC. Methods 142 newly diagnosed non-metastatic NPC, staged according the AJCC NPC were retrospectively enrolled. All had undergone contrast-enhanced...
The aim of the study was to assess efficacy and toxicity cetuximab in combined treatment for patients with recurrent and/or metastatic nasopharyngeal carcinoma (R/M NPC). Between March 2007 November 2011, a total 30 R/M NPC treated comprehensive therapy including were retrospectively enrolled. Intensity-modulated radiation delivered disease median dose 60 Gy. Chemotherapy regimens included TP/TPF (docetaxel 60-75 mg/m d1+DDP 25 d1-3±5-FU 500 mg/m/day 120-h infusion), GP (gemcitabine 1.0 g/m...