A5091167000- Cancer Immunotherapy and Biomarkers
- Immune Cell Function and Interaction
- DNA Repair Mechanisms
- Esophageal Cancer Research and Treatment
- Immune cells in cancer
- Carcinogens and Genotoxicity Assessment
- Inflammatory Biomarkers in Disease Prognosis
- MicroRNA in disease regulation
- Microtubule and mitosis dynamics
- CAR-T cell therapy research
- Head and Neck Cancer Studies
- Immune Response and Inflammation
- Gastric Cancer Management and Outcomes
- Cancer-related molecular mechanisms research
- Cell death mechanisms and regulation
- Ubiquitin and proteasome pathways
- Hepatitis C virus research
- Traumatic Brain Injury Research
- Hepatitis B Virus Studies
- Neuroblastoma Research and Treatments
- Cancer Mechanisms and Therapy
- Cancer-related Molecular Pathways
- Genetic factors in colorectal cancer
- Spinal Cord Injury Research
- Cervical Cancer and HPV Research
Shanghai Institute of Hematology
2023
Fudan University Shanghai Cancer Center
2018-2023
Shanghai Medical College of Fudan University
2021-2023
The University of Texas Southwestern Medical Center
2014-2017
Texas Oncology
2015
Institute of Modern Physics
2010-2013
Chinese Academy of Sciences
2010-2013
RAD51, a multifunctional protein, plays central role in DNA replication and homologous recombination repair, is known to be involved cancer development. We identified novel for RAD51 innate immune response signaling. Defects lead the accumulation of self-DNA cytoplasm, triggering STING-mediated after stress damage. In absence unprotected newly replicated genome degraded by exonuclease activity MRE11, fragmented nascent accumulates cytosol, initiating an response. Our data suggest that...
Cellular responses to DNA damage induced by intrinsic and extrinsic genotoxic stresses are highly regulated complex signaling pathways, such as activation of the phosphoinositide-3-kinase-like protein kinase family their downstream genes. Disruption these pathways leads genome instability cell death, thus may provide potential novel strategies for cancer therapy. Here, we find that expression a human microRNA (miRNA), hsa-miR-185, is downregulated in response ionizing radiation. Elevation...
WRN, the protein defective in Werner syndrome (WS), is a multifunctional nuclease involved DNA damage repair, replication, and genome stability maintenance. It was assumed that activities of WRN were critical for these functions. Here, we report nonenzymatic role preserving nascent strands following replication stress. We found lack led to shortening after Furthermore, discovered exonuclease activity MRE11 responsible newly replicated absence WRN. Mechanistically, N-terminal FHA domain NBS1...
Abstract Human papillomavirus (HPV)–driven oropharyngeal carcinoma (OPSCC) is distinct from tobacco- or alcohol-associated OPSCC and has a unique immune landscape. Studies have supported the heterogeneity of T cells, accompanied by broad repertoire T-cell responses, within tumors driven HPV infection. However, phenotype function these HPV-related cells remain unclear. Using combination single-cell RNA sequencing, flow cytometry, pharmacologic inhibition, immunofluorescence staining, we...
// Fengtao Su 1 , Souparno Bhattacharya Salim Abdisalaam Shibani Mukherjee 2 Hirohiko Yajima 1,4 Yanyong Yang Ritu Mishra Kalayarasan Srinivasan Subroto Ghose David J. Chen Steven M. Yannone 3 and Aroumougame Asaithamby Department of Radiation Oncology, University Texas Southwestern Medical Center, Dallas, Texas, USA Psychiatry, Life Science Division, Lawrence Berkeley National Laboratory, Berkeley, California, 4 Research Center for Charged Particle Therapy, Institute Radiological Sciences,...
Hepatocyte growth factor (HGF), an activator of the c‑Met signaling pathway, is involved in tumor invasiveness, metastasis and radiotherapy resistance. In present study, a novel HGF regulatory pathway lung cancer involving micro-RNAs (miRNAs/miR) described. Immunohistochemical staining western blot analyses demonstrated that was upregulated associated with miR‑200a downregulation non‑small cell (NSCLC) samples compared normal tissues. The association between degree malignancy migration...
Fanconi Anemia (FA) is a cancer predisposition syndrome and the factors defective in FA are involved DNA replication, damage repair tumor suppression. Here, we show that FANCD2 critical for genome stability maintenance response to high-linear energy transfer (LET) radiation. We found monoubiquitinated recruited sites of clustered double-stranded breaks (DSBs) specifically S/G2 cells after high-LET Further, facilitated DSBs proper progression S-phase. Furthermore, lack led reduced rate...
Abstract Background Cytokine release syndrome (CRS) is a systemic inflammatory response characterized by the overexpression of genes. Controlling CRS essential for improving therapeutic effects chimeric antigen receptor (CAR) engineered T cells. However, current treatment options are limited given complexity cytokine interactions so it important to seek mild strategy with broad-spectrum inhibition overcome this challenge. Methods Using THZ1, covalent inhibitor cyclin-dependent kinase 7...
Limited studies explored the relationship between lymphocyte recovery after definitive concurrent chemoradiotherapy (dCCRT) and prognosis in esophageal squamous cell carcinoma (ESCC).
Abstract Objective Compared with Occident's data, the incidence of Human papillomavirus (HPV)‐driven oropharyngeal squamous cell carcinomas (OPSCCs) had been reported as relatively low in Mainland China. The objective this study was to report integrated prevalence HPV and Epstein‐Barr virus (EBV), further evaluate different behaviors HPV‐positive ‐negative OPSCCs eastern Methods In a cohort 170 nonmetastatic treated from January 2007 July 2019, p16 protein expression, genotypes,...
This study aimed to explore the relationship between irradiation of lymphocyte-related organs at risk (LOARs) and lymphopenia during definitive concurrent chemoradiotherapy (dCCRT) for esophageal squamous cell carcinoma (ESCC).Cases ESCC patients who received dCCRT from 2 prospective clinical trials were identified. To find its correlation with survival outcomes, grades absolute lymphocyte counts (ALCs) nadir radiotherapy recorded following COX analysis. Associations lymphocytes dosimetric...
Abstract Background In recent years data from both mouse models and human tumors suggest that loss of one allele genes involved in DNA repair pathways may play a central role genomic instability carcinogenesis. Additionally several examples confirmed two functionally related have an additive effect on tumor development. To understand some the mechanisms involved, we examined monoallelic or Atm Brca1 cell transformation apoptosis induced by radiation. Methods Cell were measured embryo...
Esophageal cancer (EC) is one of the most common cancers worldwide. The prognoses for patients with same stage EC can vary substantially. progress single-cell analysis technology has furthered understanding tumor heterogeneity. This paper aimed to apply explore characteristics environment and provide a basis personalized treatment.The latest gene expression data clinical follow-up information sequencing results samples were downloaded from Cancer Genome Atlas (TCGA) Genomic Data Commons...
Purpose Esophageal cancer is the most prevalent malignant tumor. The incidence of cervical esophageal low and there are insufficient data on efficacy radical radiotherapy. purpose this study was to clarify with IFI radiotherapy, analyze pattern initial lymph node metastasis recurrence under new zoning cancer. Methods We reviewed treated inclusion criteria were diagnosis by pathology; receiving radiotherapy or chemoradiotherapy; tumor location in accordance definition Three dimensional used....
Abstract Background Both epidemiological and experimental studies suggest that heterozygosity for a single gene is linked with tumorigenesis two genes increases the risk of tumor incidence. Our previous work has demonstrated Atm/Brca1 double leads to higher cell transformation rate than heterozygosity. However, underlying mechanisms have not been fully understood yet. In present study, series pathways were investigated clarify possible increased in Atm Brca1 Methods Wild type cells, or...
Hepatitis C virus (HCV)-host cell interaction during infection disturbs cellular homeostasis and culminates in pathological consequences. The processes could be first embodied gene expression of HCV-infected cells. Here, we investigated transcriptome miRNA (miRNome) alterations Huh7 cells at 12, 36 60 h after to systematically explore host responses. number deregulated genes the increased with duration. altered biological were mainly associated stress inflammatory response, whereas most...
<div>Abstract<p>Human papillomavirus (HPV)–driven oropharyngeal carcinoma (OPSCC) is distinct from tobacco- or alcohol-associated OPSCC and has a unique immune landscape. Studies have supported the heterogeneity of T cells, accompanied by broad repertoire T-cell responses, within tumors driven HPV infection. However, phenotype function these HPV-related cells remain unclear. Using combination single-cell RNA sequencing, flow cytometry, pharmacologic inhibition, immunofluorescence...
<p>Supplementary figures and legends</p>
<div>Abstract<p>Human papillomavirus (HPV)–driven oropharyngeal carcinoma (OPSCC) is distinct from tobacco- or alcohol-associated OPSCC and has a unique immune landscape. Studies have supported the heterogeneity of T cells, accompanied by broad repertoire T-cell responses, within tumors driven HPV infection. However, phenotype function these HPV-related cells remain unclear. Using combination single-cell RNA sequencing, flow cytometry, pharmacologic inhibition, immunofluorescence...
<p>Supplementary figures and legends</p>
Abstract Background : Few studies investigate the relationship between lymphocyte recovery after definitive concurrent chemoradiotherapy (dCCRT) and prognosis in esophageal squamous cell carcinoma (ESCC). Methods ESCC patients undergoing dCCRT with obtainable absolute counts (ALCs) at 6 months were screened from prospective trials. Population categorized according to development of G4 G1-3 ALC nadir during radiotherapy. Prognostic value survival outcomes was estimated by Cox analysis....