A5100404504- Cancer-related molecular mechanisms research
- MicroRNA in disease regulation
- Circular RNAs in diseases
- RNA Research and Splicing
- RNA modifications and cancer
- Esophageal Cancer Research and Treatment
- Atherosclerosis and Cardiovascular Diseases
- Breast Cancer Treatment Studies
- Cancer Immunotherapy and Biomarkers
- Epigenetics and DNA Methylation
- Cholesterol and Lipid Metabolism
- Breast Lesions and Carcinomas
- Inflammatory Biomarkers in Disease Prognosis
- Extracellular vesicles in disease
- Congenital heart defects research
- Gut microbiota and health
- Zebrafish Biomedical Research Applications
- Bioinformatics and Genomic Networks
- Histone Deacetylase Inhibitors Research
- Gene expression and cancer classification
- Phytoestrogen effects and research
- Genetics and Neurodevelopmental Disorders
- Ginseng Biological Effects and Applications
- Kruppel-like factors research
- Signaling Pathways in Disease
Shenzhen Institutes of Advanced Technology
2023-2025
Chongqing Medical University
2021-2025
The Affiliated Yongchuan Hospital of Chongqing Medical University
2025
Shanghai First People's Hospital
2020-2024
Shanghai Jiao Tong University
2020-2024
Chongqing Three Gorges University
2024
Children's Hospital of Chongqing Medical University
2024
Chinese Academy of Medical Sciences & Peking Union Medical College
2020-2024
Central South University
2024
Third Xiangya Hospital
2024
Cardiac fibrosis is a primary phenotype of cardiac remodeling that contributes to dysfunction and heart failure. The expansion activation CD4+ T cells in the has been identified facilitate pathological dysfunction; however, underlying mechanisms remained not well clarified. Herein, we found exosomes derived from activated (CD4-activated Exos) evoked pro-fibrotic effects fibroblasts, their delivery into aggravated post-infarction. Mechanistically, miR-142-3p was enriched CD4-activated Exos...
The purpose of this study is to investigate the role high mobility group protein B1 (HMGB1) in placental development and fetal growth.
Abstract Purpose: Preclinical model found that elective nodal irradiation (ENI) attenuated the efficacy of radiotherapy and radio-immunotherapy. However, limited clinical studies have explored correlation between radiation dose-volume parameters negative tumor draining lymph nodes (TDLNs) T-cell activation/prognosis for cancer patients treated with definitive radio(chemo)therapy. Experimental Design: Patients locally advanced esophageal undergoing chemoradiotherapy (CRT) were selected from...
To examine the relationship between IL-23/IL-17 pathway gene polymorphisms and scleritis susceptibility in Chinese Han population. We assessed pathway-related SNPs 898 cases 1,573 controls, employing stratified analysis to evaluate subtype-specific impacts a discovery-validation cohort strategy ensure genetic association reliability. IL-23 R/rs10789229 TC genotype C allele, IL-21/rs2221903 TT T allele were more frequent patients (Pc = 2.07 × 10-3-2.77 10-6, OR 1.497-2.327, 95% CI...
Diffuse large B-cell lymphoma (DLBCL) is the most common non-Hodgkin’s in adult population, and treatment of DLBCL still unfavorable. Therefore, there an urgent requirement to investigate molecular mechanisms underlying tumorigenesis. To study potential function microRNA-155 (miR-155) involved regulation lymphoma, we monitored cell behavior including proliferation, cycle, apoptosis using CCK-8 flow cytometry analysis. Real-time PCR was used detect expression levels miR-155 118 patients’...
Abstract The intestine of Haemonchus contortus is an essential tissue that has been indicated to be a major target for the prevention haemonchosis caused by this parasitic nematode small ruminants. Biological peculiarities warrant in-depth exploitation, which can leveraged future disease control efforts. Here, we determined intestinal ncRNA (lncRNA, circRNA and miRNA) atlas using whole-transcriptome sequencing bioinformatics approaches. In total, 4846 novel lncRNA, 982 circRNA, 96 miRNA (65...
HACE1 is a member of the HECT domain-containing E3 ligases with 909 amino acid residues, containing N-terminal ankyrin-repeats (ANK) and C-terminal domain. Previously, it was shown that inactive in human tumors plays crucial role initiation, progression, invasion malignant tumors. Recent studies indicated might be closely involved neurodegenerative diseases such as Alzheimer's disease, Parkinson's Huntington's disease. interacts its substrates, including Ras-related C3 botulinum toxin...
Emerging evidence suggests that many differentially expressed long non-coding RNAs (lncRNAs) are involved in tumorigenesis. However, the functional roles of these transcripts and mechanisms responsible for their deregulation non-small-cell lung cancer (NSCLC) remain elusive. Here, we identified a novel lncRNA (lncRNA 1308), which was significantly upregulated NSCLC tissues investigated its biological function potential molecular mechanism.Differences expression profiles between...
Limited studies explored the relationship between lymphocyte recovery after definitive concurrent chemoradiotherapy (dCCRT) and prognosis in esophageal squamous cell carcinoma (ESCC).
Cell apoptosis induced by Angiotensin II (Ang II) has a critical role in the development of cardiovascular diseases. The aim present study was to investigate whether sanguinarine (SAN), drug which proved have anti‑oxidant, anti‑proliferative and immune enhancing effects, can abolish cell Ang II. In study, H9c2 cardiac cells were stimulated with 10 µM or without SAN. level intracellular reactive oxygen species (ROS) generation assessed using dichlorodihydrofluorescein diacetate, changes...
Global DNA and histone methylation patterns in astrocytes following ischemia are influenced by age; however, it is unknown whether aberrant can induce reactive astrogliosis after ischemic stroke elderly rodents. Here we showed that phosphorylated signal transducer activator of transcription 3 (STAT3) level increased along with the marker glial fibrillary acidic protein (GFAP) on days 1, 3, 14 post-reperfusion 9-month-old male mice middle cerebral artery occlusion (MCAO). Methylation STAT3...
The inducible IκB kinase (IKKi/IKKε) is a recently described serine-threonine IKK-related kinase. Previous studies have reported the role of IKKi in infectious diseases and cancer. However, its cardiac response to pressure overload remains elusive. In this study, we investigated effects deficiency on development pathological hypertrophy using vitro vivo models. First, developed mouse models induced by aortic banding (AB). Four weeks after AB, function was then assessed through...
MiR-128, one of the most enriched miRNAs in human brain, has been reported to protect MCAO mice via inhibiting P38α MAPK. Whether it is involved pathogenesis acute ischemic stroke patients remains be determined. The present study focused on clinical importance miR-128 and its underlying mechanisms. We detected levels circulating lymphocytes, neutrophils, plasma by using RT-PCR. were significantly elevated with stroke. In addition, lymphocytes correlated positively infarction volume, NIHSS...
Cartilage-hair hypoplasia (CHH) is an autosomal recessive metaphyseal chondrodysplasia characterized by bone dysplasia and many other highly variable features. The gene responsible for CHH the RNA component of mitochondrial RNA-processing endoribonuclease (RMRP) gene. Currently, pathogenesis osteochondrodysplasia extraskeletal manifestations in patients remains incompletely understood; addition, there are no viable animal models CHH. We generated rmrp KO zebrafish model to study...
Tyrosine kinase inhibitor (TKI) therapy has greatly improved lung cancer survival in patients with epidermal growth factor receptor (EGFR) mutations. However, the development of TKI-acquired resistance is major problem to be overcome. In this study, we found that miR-196a expression was induced gefitinib-resistant cells. To understand role and mechanism TKI resistance, miR-196a-forced alone increased cell gefitinib treatment vitro vivo by inducing proliferation inhibiting apoptosis. We...
Background and Objectives: Whether post-mastectomy radiotherapy (PMRT) could improve prognosis for T1-2 breast cancer patients with one to three lymph node metastases remains controversial. The present study aimed determine the significance of PMRT in T1-2N1M0 cancer. Methods: Data 45,646 from Surveillance, Epidemiology, End Results (SEER) database were analyzed; 12,585 matched divided into a group non-radiotherapy (no-PMRT), respectively, using propensity score matching method. Univariate...
As a near-physiological pacing innovation, left bundle branch area (LBBAP) has drawn much attention recently. This study was aimed to investigate the electrophysiological characteristics, unipolar/bipolar parameters and mid- long-term effects safety of three different methods identify possible predictors adverse ventricular remodeling.Ninety-two patients were divided into LBBAP group, right septal (RVSP) group apical (RVAP) group. Baseline information, electrophysiological, echocardiographic...
Long noncoding RNAs (lncRNAs) have close correlation with tumorigenesis. And how lncRNAs participate in lung cancer require investigation in-depth. The aim of this study was to determine the role lncRNA PSMA3-AS1 progression.PSMA3-AS1 expression analyzed via qRT-PCR. Kaplan-Meier method used analyze survival rate based on value. Proliferation measured CCK8 and colony formation assays. Transwell assay utilized examine migration invasion. Luciferase reporter RNA pulldown were interaction...
Abstract Background The evidence of breast-conserving therapy (BCT) applied in centrally located breast cancer (CLBC) is absent. This study aims to investigate the long-term survival compared with mastectomy CLBC and BCT non-CLBC. Methods Two hundred ten thousand four nine women unilateral T1-2 undergoing or were identified from Surveillance, Epidemiology, End Results database. Kaplan–Meier curves assessed via log-rank test. Propensity score matching (PSM) was used balance baseline features,...