A5083243587- Spectroscopy and Laser Applications
- Advanced Fiber Laser Technologies
- Photonic and Optical Devices
- RNA modifications and cancer
- Terahertz technology and applications
- Autophagy in Disease and Therapy
- Gut microbiota and health
- Diet and metabolism studies
- Endoplasmic Reticulum Stress and Disease
- Viral-associated cancers and disorders
- Metamaterials and Metasurfaces Applications
- Cancer-related molecular mechanisms research
- Laser Design and Applications
- Molecular Sensors and Ion Detection
- Cancer-related gene regulation
- Plasmonic and Surface Plasmon Research
- Diet, Metabolism, and Disease
- RNA Research and Splicing
- Wound Healing and Treatments
- Liver Disease Diagnosis and Treatment
- Mitochondrial Function and Pathology
- Epigenetics and DNA Methylation
- Land Use and Ecosystem Services
- Folate and B Vitamins Research
- CRISPR and Genetic Engineering
Army Medical University
2016-2025
Henan Agricultural University
2025
Shanghai Jiao Tong University
2020-2024
Shanghai Ninth People's Hospital
2020-2024
Anhui Medical University
2024
Nanjing Medical University
2023-2024
Shanghai Institute of Microsystem and Information Technology
2019-2023
Chinese Academy of Sciences
2013-2023
University of Chinese Academy of Sciences
2013-2023
Affiliated Hospital of Southwest Medical University
2023
Cancer is a common comorbidity of diabetic patients; however, little known about the effects that antidiabetic drugs have on tumors. We discovered classes used in type 2 diabetes mellitus, hypoglycemic dipeptidyl peptidase-4 inhibitors (DPP-4i) saxagliptin and sitagliptin, as well antineuropathic α-lipoic acid (ALA), do not increase tumor incidence but risk metastasis existing Specifically, these induce prolonged activation nuclear factor E2-related (NRF2)-mediated antioxidant response...
Long non-coding RNAs (LncRNAs) have been recently found to be pervasively transcribed in the genome and critical regulators of epigenome. HOTAIR, as a well-known LncRNA, has play important roles several tumors. Herein, clinical application value biological functions HOTAIR were focused explored esophageal squamous cell carcinoma (ESCC). It was that there great upregulation ESCC compared their adjacent normal tissues. Meanwhile, patients with high expression significantly poorer prognosis...
Nutrition and its associated inflammation have been acknowledged as vital factors in the etiopathogenesis of non-alcoholic fatty liver disease (NAFLD) fibrosis. The nutritional risk index (NRI) has widely recognized a valid indicator status several diseases, including osteoporosis cardiovascular disease. However, role NRI NAFLD fibrosis remains unclear. Participants were selected from National Health Examination Survey data for 2017–2018 cycle. Association between both was evaluated using...
The genetic mechanisms underlying the poor prognosis of esophageal squamous cell carcinoma (ESCC) are not well understood. Here, we report somatic mutations found in ESCC from sequencing 10 whole-genome and 57 whole-exome matched tumor-normal sample pairs. Among identified genes, characterized VANGL1 showed that they accelerated growth vitro. We also five other including three coding genes (SHANK2, MYBL2, FADD) two non-coding (miR-4707-5p, PCAT1), were involved copy-number alterations...
Hypoxia is a physiological stress that frequently occurs in solid tissues. Autophagy, ubiquitous degradation/recycling system eukaryotic cells, renders cells tolerant to multiple stressors. However, the mechanisms underlying autophagy initiation upon hypoxia remains unclear. Here we show protein arginine methyltransferase 5 (PRMT5) catalyzes symmetrical dimethylation of ULK1 at 170 (R170me2s), modification removed by lysine demethylase 5C (KDM5C). Despite unchanged PRMT5-mediated...
Esophageal squamous cell carcinoma (ESCC), one of the most aggressive cancers, is characterized by heterogeneous genetic and epigenetic changes. Recently, A-to-I RNA editing, catalyzed adenosine deaminases acting on (ADARs), was found to be aberrantly regulated during tumorigenesis. We previously reported that ADAR2 downregulated in ESCC but its role unclear. Thus, we report here overexpression can induce apoptosis lines inhibit tumor growth vitro vivo. knockdown inhibited highly expressing...
BackgroundIncreasing evidence indicates that the gut microbiota contributes to occurrence and development of metabolic diseases. However, little is known about effects commonly used antidiabetic agents on microbiota. In this study, we investigated roles dipeptidyl peptidase-4 inhibitors (DPP-4i) α-glucosidase inhibitor in modulating microbiota.Methods16S-rDNA sequencing was performed analyse DPP-4i acarbose mice fed a high-fat diet (HFD). Fecal transplantation (FMT) from type 2 diabetes...
Due to its fast and high-resolution characteristics, dual-comb spectroscopy has attracted an increasing amount of interest since first demonstration. In the terahertz frequency range where abundant absorption lines (fingerprints) molecules are located, multiheterodyne that employs technique shows advantage in real-time spectral detection over traditional Fourier transform infrared or time domain spectroscopies. Here, we demonstrate compact based on quantum cascade lasers (QCLs). our...
Abstract Recently, there are growing interests in developing super‐resolution metalenses for applications of focusing and imaging. On one hand, various sub‐diffraction have been demonstrated; however, most them only work at a single wavelength or multiple discrete wavelengths. the other previously reported broadband achromatic diffraction‐limited, their focal spots larger than corresponding Abbe diffraction limit, 0.5λ/NA, where λ NA lens working numerical aperture. In present work, an...
Abstract Aberrant expression of receptor interacting protein kinase 4 (RIPK4), a crucial regulatory Wnt/β-catenin signaling, has recently been reported to be involved in several cancers. Here, we report the potential clinical implication and biological functions RIPK4 cervical squamous cell carcinoma (CSCC). One hundred ninety-eight CSCC cases, 109 low-grade intraepithelial lesions (LSILs), 141 high-grade (HSILs) 63 chronic cervicitis were collected. The was detected by immunohistochemistry...
Mitochondrial glycerol 3-phosphate dehydrogenase (mGPDH) is an integral component of the respiratory chain, and recent studies have suggested that it plays important role in hepatic glucose homeostasis. However, its function lipid metabolism unclear. Here, we identified a for mGPDH nonalcoholic fatty liver disease (NAFLD). Specifically, expression activity were lower livers from patients mice with NAFLD (ob/ob, high-fat diet [HFD] db/db). Liver-specific depletion or knockdown cultured...
Chromatic optical lenses have promising applications in three-dimensional imaging, which allows fast spectral tomography without mechanical moving parts. The scanning range of current chromatic is limited by their dispersion ability. recent development metasurfaces provides ideal blocks for wavefront manipulation and engineering artificial materials at sub-wavelength scales. Hyper-dispersive metalenses can be realized utilizing dispersive meta-atoms, enhanced compared to regular diffractive...
Under the fast-paced urban lifestyle, many residents suffer from sub-health. Forest-based health and wellness tourism is an effective way to relieve psychological physiological stress. Urban forest parks play a key role in construction. However, management of still unreasonable, so economic, social, ecological benefits these cannot be continuously utilized. In order manage perspective wellness, three categories indicators, namely visual sensitivity, characteristics, soil properties, were...
Interleukin-22 (IL-22) has been demonstrated to be involved in the regulation of glucose metabolism, insulin resistance and inflammation response, which indicates that IL-22 might associated with occurrence progression diabetes. This study aimed assess serum levels participants type 2 diabetes mellitus (T2DM) analyze association between T2DM risk. Serum concentrations recruited healthy (n=48), newly diagnosed (n=46), receiving placebo (n=7) or dipeptidyl peptidase-4 inhibitors (DPP-4i)...
Oral squamous cell carcinoma (OSCC) is one of the most common cancers worldwide, and with 354 864 new cases each year. Cancer metastasis, recurrence, drug resistance are main causes to cripples deaths OSCC patients. As potent growth factors, fibroblast factors (FGFs) frequently susceptible being hijacked by cancer cells. In this study, we show that FGF8 upregulated in tissues high expression related a set clinicopathologic parameters, including age, drinking, survival time. treatment...
Lysosomal-associated membrane protein 3 (LAMP3), identified as a molecular marker of mature dendritic cells, is one the LAMP family members. Its expression was induced by hypoxia, and associated with hypoxia mediated metastasis in breast cervical cancers. However, epithelial LAMP3 its prognostic value esophageal squamous cell carcinoma (ESCC) still unknown. In current study, mRNA 157 ESCC tissues 50 adjacent normal detected quantitative real-time PCR (qRT-PCR). 46 paired cancerous...
Research Article2 November 2018Open Access Source DataTransparent process Mitochondrial glycerol 3-phosphate dehydrogenase promotes skeletal muscle regeneration Xiufei Liu Translational Key Laboratory for Diabetes, Department of Endocrinology, Xinqiao Hospital, Third Military Medical University, Chongqing, China Search more papers by this author Hua Qu Yi Zheng Qian Liao Linlin Zhang Xiaoyu Xin Xiong Yuren Wang Rui Hui Qiang Tong Zhenqi Division Endocrinology and Metabolism, Internal...
High levels of branched-chain amino acids (BCAAs) and aromatic (AAAs) were associated with an increased risk hyperglycemia the onset diabetes. This study is aimed at assessing circulating valine concentrations in subjects type 2 diabetes (T2D) T2D patients high-fat diet- (HFD-) fed mice treated hypoglycemic agent sitagliptin (Sit) analyzing association metabolic parameters.Metabolomics HFD-fed analyzed by gas chromatography-mass spectrometry (GC-MS) systems. Plasma detected a commercial kit...
Oral Epstein-Barr virus (EBV) status reflects host EBV activity and potentially links to EBV-associated diseases, however, factors influencing oral loads or reactivation, such as environmental exposures factors, are not fully understood.A 2-stage, multicenter, cross-sectional study of 6558 subjects from 21 administrative cities southern China 3 populations representative geographical areas in (referred the south, north, northeastern populations) was performed. The relationships between...
High-power broadband terahertz dual-comb sources are of great importance for fast high-resolution spectroscopy, but rare because the lack high-performance radiation sources. Here authors demonstrate a source on chip, based electrically pumped quantum cascade lasers and microwave double injection. By injection locking two at slightly different round-trip frequencies, even weak power can significantly broaden bandwidth. Furthermore, double-injection technique allows direct evaluation carrier...