A5081650425- Breast Cancer Treatment Studies
- Breast Lesions and Carcinomas
- S100 Proteins and Annexins
- Ferroptosis and cancer prognosis
- Hippo pathway signaling and YAP/TAZ
- Cancer Diagnosis and Treatment
- Cancer Research and Treatments
- Cancer Mechanisms and Therapy
- Cancer-related Molecular Pathways
- RNA Interference and Gene Delivery
- Cancer Risks and Factors
- Thyroid Cancer Diagnosis and Treatment
- HER2/EGFR in Cancer Research
- Breast Implant and Reconstruction
- Cancer-related gene regulation
- Cancer-related molecular mechanisms research
- Cancer Treatment and Pharmacology
- Esophageal and GI Pathology
- Epigenetics and DNA Methylation
- Wnt/β-catenin signaling in development and cancer
- Electrospun Nanofibers in Biomedical Applications
- Mechanisms of cancer metastasis
- Cancer Immunotherapy and Biomarkers
- Radiopharmaceutical Chemistry and Applications
- Bioinformatics and Genomic Networks
University of Electronic Science and Technology of China
2024-2025
Sichuan Cancer Hospital
2024-2025
Affiliated Hospital of North Sichuan Medical College
2012-2024
Yangtze River Pharmaceutical Group (China)
2024
North Sichuan Medical University
2019-2024
Southwest Hospital
2008-2022
Sichuan University
2021-2022
West China Hospital of Sichuan University
2021-2022
First Affiliated Hospital of Shihezi University Medical College
2018
Army Medical University
2008-2018
Background Glioma is the most malignant cancer in brain. As a major vitamin-K-dependent protein central nervous system, PROS1 not only plays vital role blood coagulation, and some studies have found that it was associated with tumor immune infiltration. However, prognostic significance of glioma underlying mechanism shaping microenvironment (TIME) remains unclear. Methods The raw data (including RNA-seq, sgRNA-seq, clinicopathological variables prognosis, survival data) were acquired from...
Annexins are associated with metastasis and infiltration of cancer cells. Proteomic analysis immunohistochemical staining were used to understand whether several annexins play important roles in alone and/or synergistically. Seven fresh breast samples 23 paraffin specimens, three pancreatic five laryngeal carcinoma 25 specimens obtained from humans, as well ten golden hamster tissue samples, they observe differential expression compared normal tissues using proteomics staining. Annexin A2,...
Neoadjuvant chemotherapy (NAC), the systematic given to patients with locally advanced and inoperable breast caner, has been proven be of great clinical values. Many scientific reports confirmed NAC could effectively eliminate sub-clinical disseminated lesions tumor, improve long-term disease-free survival rate cancer (LABC); however, up now, LABC is still a serious issue improved screening early diagnosis. This study, main focus on LABC, investigated values in converting into operable...
Triple-negative breast cancer (TNBC) cells have not been usefully classified, and no targeted therapeutic plans are currently available, resulting in a high recurrence rate metastasis potential. In this research, CD24high accounted for the vast majority of TNBC cells, they were insensitive to Taxol but sensitive ferroptosis agonists effectively escaped phagocytosis by tumor-associated macrophages. Furthermore, NF2–YAP signaling axis modulated expression suppressor protein 1 (FSP1) CD24 with...
Abstract Krüppel‐like factor 4 (KLF4) was closely associated with epithelial‐mesenchymal transition and stemness in colorectal cancer stem cells (CSCs)‐enriched spheroid cells. Nonetheless, the underlying molecular mechanism is unclear. This study showed that KLF4 overexpression accompanied mesenchymal features Lgr5 + CD44 EpCAM CSCs. knockdown suppressed stemness, activation of TGF‐β1 pathway, whereas enforced activated TGF‐β1, phosphorylation Smad 2/3 Snail expression, restored phenotypes....
Triple-negative breast cancer (TNBC) is the most malignant type of and lacks effective targeted therapeutic drugs, resulting in a high recurrence rate worse outcome. In this study, bioinformatic analysis series experiments demonstrated that MOCR2 was highly expressed TNBC closely associated with poor prognosis, indicating may be potential target for TNBC. Subsequently, Angoline identified as an inhibitor MORC2 protein by high-throughput screening can significantly kill cells blocking cell...
BACKGROUND Breast cancer is the main type of in women, and triple-negative breast (TNBC) a unique subtype cancer. The expression miR-940 has been shown to play an important role various cancers; however, TNBC remains unknown. MATERIAL AND METHODS tissues or cells were tested by qRT-PCR; overexpressed mimics, suppressed anti-miR-940. Bioinformatics algorithms from TargetScanHuman used predict target genes miR-940. interaction between ZNF24 was confirmed dual luciferase assays. protein level...
DNA double-strand breaks (DSBs) yield highly determines radiotherapy efficacy. However, improving the inherent radiosensitivity of tumor to promote radiation-induced DSBs remains a challenge. Using theoretical and experimental models, underexplored impact Z-DNA conformations on radiosensitivity, yielding higher than other conformations, is discovered. Thereout, radiosensitization strategy focused inducing conformation, utilizing CBL@HfO
Triple-negative breast cancer (TNBC) is an aggressive subtype of that often associated with biologic behavior frequent distant metastasis. FAT tumor suppressor homolog 4 (FAT4), a cadherin-related protein, involved in variety biological processes as suppressor; however, the role FAT4 TNBC still unclear. The aim our study was to identify and examine underlying molecular mechanisms. expression evaluated by immunohistochemistry, western blotting, qRT-PCR series tissues. effects on ability cell...
Abstract Abnormal expression of annexin A2 contributes to metastasis and infiltration cancer cells. To elucidate the cause abnormal A2, Western blotting, immunoproteomics immunohistochemical staining were performed analyze differentially ubiquitinated proteins between fresh breast tissue its adjacent normal from five female volunteers. We detected an protein that was up-regulated in tissue, which further identified as by mass spectrometry. These results suggest ubiquitination and/or...
Bisphenol A diglycidyl ether (BADGE), a PPARγ2 antagonist, has been shown to inhibit marrow adipogenesis and promote bone formation in intact animals. We investigated the impact of BADGE on new more clinically relevant physiological model, ovariectomized (OVX) rat model. Forty female Wistar rats were divided into four treatment groups for 12 wk ( n = 10/group): sham+vehicle, sham+BADGE, OVX+vehicle, OVX+BADGE. Postmortem analyses included MRI, micro-CT, serological test, histomorphometry,...
In recent years, traditional Chinese medicine (TCM) has been developing rapidly in cancer treatment. Huaier is a widely used fungus by TCM to treat different kinds of cancers. Its good efficacy prevention tumor recurrence and metastasis proven large number clinical studies. order further investigate the safety granules post-surgical therapy for stage I-III triple-negative breast (TNBC) patients, we performed case-control study observe its effects on survival rates these patients.Two hundred...
Abstract The loss of progesterone receptor (PR) often predicts worse biological behavior and prognosis in estrogen receptor-positive (ER +) breast cancer. However, the impact PR status on inflammatory cancer (IBC) has not been studied. Therefore, purpose our study was to investigate influence IBC. Patients with ER+ HER2-negative IBC were selected from Surveillance, Epidemiology End Results database. Pearson’s χ 2 test used compare clinicopathological characteristics between patients...
Abstract Breast cancer is one of the major challenges for women's health. However, role and mechanisms interleukins ( IL s) on progression breast are not well illustrated. Our present study revealed that expressions ‐6 ‐8 were significantly increased in oestrogen receptor‐negative ER −) cells. Increased expression was observed 83.9% (26/31) − tissues as compared with their matched adjacent normal tissues. In vitro studies indicated can promote migration invasion cells via increasing...
The role of supraclavicular lymph node dissection (SCLD) in the treatment breast cancer with ipsilateral metastasis (ISLM) remains controversial. We evaluated SCLD ISLM and identified patients who may benefit from SCLD.Data on presenting to Breast Disease Center, Southwest Hospital, Army Medical University January 2004 December 2017 were retrospectively screened. median duration follow-up was 36 months (2-175 months). 305 recently diagnosed eligible for analysis.Overall, 9,236 women...
Background and Objectives: Whether post-mastectomy radiotherapy (PMRT) could improve prognosis for T1-2 breast cancer patients with one to three lymph node metastases remains controversial. The present study aimed determine the significance of PMRT in T1-2N1M0 cancer. Methods: Data 45,646 from Surveillance, Epidemiology, End Results (SEER) database were analyzed; 12,585 matched divided into a group non-radiotherapy (no-PMRT), respectively, using propensity score matching method. Univariate...
To assess the differential features of marrow adiposity between osteoarthritis (OA) and osteoporosis (OP) in postmenopausal women using water/fat MRI.This cross-sectional study included 97 (OA [n = 25], OA + osteopenia 27], OP 23], groups 22]). Water/fat MRI, dual-energy x-ray absorptiometry biochemical analysis were performed to vertebral fat fraction, bone mineral density, biomarkers, respectively. Harris Hip Score was recorded evaluate hip function.There significant differences content...
Breast cancer is the most common worldwide. Low DNAJB4 expression levels are strongly correlated with poor prognosis in breast patients. However, molecular mechanism by which regulates progression unclear.The of was validated human tissues, normal and cell lines. CCK-8, colony-forming, wound healing assays were used to assess biological effect overexpression on proliferation migration MCF-7 Bioinformatic analysis identify related pathways cancer. Epithelial-mesenchymal transition...