A5100626329- Spinal Fractures and Fixation Techniques
- Spine and Intervertebral Disc Pathology
- Breast Cancer Treatment Studies
- Ferroptosis and cancer prognosis
- Scoliosis diagnosis and treatment
- Cervical and Thoracic Myelopathy
- HER2/EGFR in Cancer Research
- Air Quality and Health Impacts
- RNA modifications and cancer
- Cancer Mechanisms and Therapy
- Radiomics and Machine Learning in Medical Imaging
- Climate Change and Health Impacts
- Cancer Immunotherapy and Biomarkers
- Mechanisms of cancer metastasis
- Prostate Cancer Treatment and Research
- Peptidase Inhibition and Analysis
- DNA Repair Mechanisms
- Prostate Cancer Diagnosis and Treatment
- Cancer-related molecular mechanisms research
- Cancer-related gene regulation
- Immune cells in cancer
- Pelvic and Acetabular Injuries
- Monoclonal and Polyclonal Antibodies Research
- Air Quality Monitoring and Forecasting
- Inflammatory mediators and NSAID effects
Southwest Hospital
2016-2025
Army Medical University
2016-2025
Research Center for Eco-Environmental Sciences
2024-2025
State Key Laboratory of Environmental Chemistry and Ecotoxicology
2025
Chinese Academy of Sciences
2024-2025
University of Chinese Academy of Sciences
2025
Sichuan University
2012-2025
West China Hospital of Sichuan University
2012-2025
Sino-Danish Centre for Education and Research
2025
Nanfang Hospital
2022-2024
Abstract Helicobacter pylori , particularly cytotoxin-associated gene A (CagA)-positive strains, plays a key role in the progression of gastric cancer (GC). Ferroptosis, associated with lethal lipid peroxidation, has emerged to play an important malignant and infectious diseases, but CagA ferroptosis cells not been determined. Here, we report that confers GC sensitivity both vitro vivo. Mechanistically, promotes synthesis polyunsaturated ether phospholipids (PUFA-ePLs), which is mediated by...
Plant genotype drives the development of plant phenotypes and assembly microbiota, but potential influence phenotypic characters on its microbiota is not well characterized co-occurrence interrelations for specific microbial taxa are poorly understood. We established a common garden experiment, quantifying prokaryotic fungal communities in phyllosphere rhizosphere six spruce (Picea spp.) tree species, through Illumina amplicon sequencing. tested relationships between bacterial/archaeal their...
OBJECTIVE One vexing problem after lateral lumbar interbody fusion (LLIF) surgery is cage subsidence. Low bone mineral density (BMD) may contribute to subsidence, and BMD correlated with Hounsfield units (HUs) on CT. The authors investigated if lower HU values subsidence LLIF. METHODS A retrospective study of patients undergoing single-level LLIF pedicle screw fixation for degenerative conditions at the University California, San Francisco, by 6 spine surgeons was performed. Data...
The content of single heavy metal in blood is associated with lung function decline, but there little evidence on the joint effect multiple metals function. To explore whether mixture exposure reduction among young adults. study based a cohort 518 students recruited from college Shandong, China. We measured their and concentrations. BKMR model was used to analyse association between levels function, identify critical which contributes most effects. As sensitivity analysis, we quantile...
Breast cancer is one of the most common female malignant tumors today and represents a serious health risk for women. Although survival rate quality life patients with breast are improving continuous development medical technology, metastasis, recurrence, drug resistance remain significant problem. Huaier, traditional Chinese medicine (TCM) fungus, type Sophora embolism fungus growing on old stems. The polysaccharides Trametes robiniophila Murr (PS-T) main active ingredient Huaier. There...
Specific killing of erbB-2-overexpressing tumor cells can be achieved using expression an intracellular antibody directed against the erbB-2 oncoprotein. We have developed a strategy recombinant adenovirus encoding anti-erbB-2 single chain to achieve targeted cell in vivo and show significantly prolonged survival animals carrying human ovarian carcinoma burden within their peritoneal cavities. This gene therapy for offers potential highly specific, thus establishes rationale undertake...
Neoadjuvant chemotherapy (NAC), the systematic given to patients with locally advanced and inoperable breast caner, has been proven be of great clinical values. Many scientific reports confirmed NAC could effectively eliminate sub-clinical disseminated lesions tumor, improve long-term disease-free survival rate cancer (LABC); however, up now, LABC is still a serious issue improved screening early diagnosis. This study, main focus on LABC, investigated values in converting into operable...
Multigene panel testing of breast cancer predisposition genes have been extensively conducted in Europe and America, which is relatively rare Asia however. In this study, we assessed the frequency germline mutations 40 genes, including BRCA1 BRCA2 , among a large cohort Chinese patients with high hereditary risk BC. From 2015 to 2016, consecutive BC from 26 centers China were recruited (n = 937). Clinical information was collected next‐generation sequencing (NGS) performed using blood...
OBJECTIVE Patients undergoing long-segment fusions from the lower thoracic (LT) spine to sacrum for adult spinal deformity (ASD) correction are at risk proximal junctional kyphosis (PJK). One mechanism of PJK is fracture upper instrumented vertebra (UIV) or higher (UIV+1), which may be related bone mineral density (BMD). Because Hounsfield units (HUs) on CT correlate with BMD, authors evaluated whether HU values were correlated after long ASD. METHODS The performed a retrospective study...
The health impact of short-term heat exposure is well documented. However, limited studies explored the association between life-time summer and lung function. To examine function among young adults. We conducted a retrospective cohort study 1928 college students in Shandong, China from September 4, 2020 to November 15, 2020. Life-time for participants were estimated based on nearest station meteorological data after participant's birth date divided by their learning phases. Lung indicators...
Although the anti-programmed death-1 (PD-1) inhibitor plus chemotherapy combination has been approved as standard first-line treatment for advanced gastric cancer, a proportion of patients do not significantly benefit from this therapy. Who would respond poorly to and underlying mechanisms failure are far clear.We retrospectively analyzed associations between peripheral basophils at baseline clinical outcomes in 63 cancer treated with anti-PD-1 54 alone. Immunohistochemistry...
Nucleolar and spindle-associated protein 1 (NUSAP1) is a microtubule-associated that plays crucial role in mitosis.Despite initial reports suggesting potential involvement of NUSAP1 tumor progression malignant cell regulation, there has been no systematic analysis its the immune microenvironment, nor predictive value for prognosis immunotherapy response across different cancer types.In this study, we analyze mRNA expression levels various human normal tissues, using data from TCGA, GTEx,...
ADVERTISEMENT RETURN TO ISSUEHighlightNEXTA Missing Puzzle Piece of Pollutant Metabolism in Humans: The Gut MicrobiotaMeilin LvMeilin LvCollege Sciences, Northeastern University, Shenyang 110004, ChinaState Key Laboratory Environmental Chemistry and Ecotoxicology, Research Center for Eco-Environmental Chinese Academy Beijing 100085, ChinaMore by Meilin Lv, Yanna LiuYanna LiuState Liuhttps://orcid.org/0000-0001-7893-9876, Chunzhen ShiChunzhen ShiState ChinaCollege Ecology Environment,...
Perfluorooctanoic acid (PFOA) is a persistent pollutant that has gained worldwide attention, owing to its widespread presence in the environment. Previous studies have reported PFOA upregulates lipid metabolism and associated with liver injury humans. However, when fatty degradation pathway activated, accumulation still occurs, suggesting of unknown pathways mechanisms remain be elucidated. In this study, adult C57BL/6N mice were exposed at 0.1, 1, 10 mg/kg/day. Using integrated metabolomics...
500 Background: Fumarate hydratase–deficient renal cell carcinoma (FH-deficient RCC) is a rare subtype of kidney cancer characterized by FH-inactivating alterations. Studies have revealed highly immunogenic features in this lethal disease, providing molecular evidence for implement immune checkpoint inhibitor (ICI). Due to the nature FH-deficient RCC, significant proportion patients continue disease progression after receiving ICI combination therapy (ICI plus tyrosine kinase inhibitors,...
Aberrant epigenetic and transcriptional events that drive cancer progression could be precisely targeted. We aimed to uncover the roles of RBBP7 on breast (BCa) stemness metastasis. The bioinformatic analysis was used assess clinical significance in BCa. CCK8, colony formation, Transwell assays were utilized estimate oncogenic functions RBBP7. ChIP-qPCR dual-luciferase reporter investigate mechanisms Tumor sphere formation conducted self-renewal abilities BCa cells. Tail vein injection...
The Fruit-Weight like (FWL) family of plants is ubiquitous in different species, and some members this have been shown to play an indispensable role regulating plant growth, development, response heavy metal stress. This study comprehensively identifies characterizes the FWL gene Oryza sativa, underscoring its significant arsenic stress ion homeostasis. Through bioinformatics analysis, eight genes were identified grouped into two subfamilies based on phylogenetic tree. These further analyzed...
Triple negative breast cancer (TNBC) is a highly aggressive and lack of targeting therapies.It believed that the stem cells (BCSCs) are responsible for characteristics TNBC.Hence, developing BCSC-targeting agents may provide new therapeutic strategies patients.Huaier polysaccharide (HP), an active ingredient extracted from mushroom Trametes robiniophila Murr, has been widely used in clinical anti-cancer treatments China.Here we demonstrated HP could target BCSCs TNBC cells, resulting...
A consequence of anterior cervical discectomy and fusion (ACDF) is graft subsidence, potentially leading to kyphosis, nonunion, foraminal stenosis, recurrent pain. Bone density, as measured in Hounsfield units (HUs) on CT, may be associated with subsidence. The authors evaluated the association between HUs subsidence rates after ACDF.