A5041927337- Retinal Diseases and Treatments
- Adenosine and Purinergic Signaling
- Cancer-related molecular mechanisms research
- Barrier Structure and Function Studies
- Lipid metabolism and disorders
- Retinal Imaging and Analysis
- Autophagy in Disease and Therapy
- Inflammasome and immune disorders
- Diabetes Treatment and Management
- Neuroinflammation and Neurodegeneration Mechanisms
- Liver Disease Diagnosis and Treatment
- Advanced Glycation End Products research
- Diet, Metabolism, and Disease
- Retinoids in leukemia and cellular processes
- Receptor Mechanisms and Signaling
- Ion Channels and Receptors
- Plant Stress Responses and Tolerance
- Hypothalamic control of reproductive hormones
- Pregnancy-related medical research
- Pharmacology and Obesity Treatment
- Medical and Biological Ozone Research
- Hydrogen's biological and therapeutic effects
- Traditional Chinese Medicine Analysis
- Glaucoma and retinal disorders
- Atherosclerosis and Cardiovascular Diseases
Harbin Medical University
2017-2024
First Affiliated Hospital of Harbin Medical University
2017-2024
Zhejiang A & F University
2024
BaiCheng Normal University
2023
Mudanjiang Medical University
2023
Hunan Agricultural University
2021-2022
China Pharmaceutical University
2021-2022
Chifeng Municipal Hospital
2020
Ruijin Hospital
2017
Shanghai Jiao Tong University
2017
Introduction: It is known that the metabolic disorder caused by high glucose one of pathogenesis in diabetic retinopathy (DR), leading cause blindness, due to main pathological change apoptosis endothelial cells (ECs). In previous studies, potential impact sodium cotransporter-2 (SGLT-2), whose inhibitors slow progression DR, has not been elucidated. The purpose presented study was explore effect SGLT-2 dapagliflozin (DAPA) on mice retina and human retinal microvascular (HRMECs), examine...
GLP-1 analogs have been widely used to treat patients with type 2 diabetes in recent years and studies found that multiple organ benefits. However, the role of diabetic retinopathy (DR), a common complication mellitus (DM), remains controversial. Retinal ganglion cells (RGCs) are only afferent neurons responsible for transmitting visual information center vulnerable early stage DR. Protection RGC is vital function. The incretin glucagon-like peptide-1 (GLP-1), which secreted by L-cells after...
The Fruit-Weight like (FWL) family of plants is ubiquitous in different species, and some members this have been shown to play an indispensable role regulating plant growth, development, response heavy metal stress. This study comprehensively identifies characterizes the FWL gene Oryza sativa, underscoring its significant arsenic stress ion homeostasis. Through bioinformatics analysis, eight genes were identified grouped into two subfamilies based on phylogenetic tree. These further analyzed...
This study is aimed at investigating whether exenatide (Exe) delays the progression of nonalcoholic fatty liver disease (NAFLD) in C57BL/6 mice by targeting NLRP3 inflammasome through autophagy/mitophagy pathway. Thirty male were randomly divided into three groups: control group (n = 10), model and Exe (exenatide) 10). Mouse models NAFLD diabetes established using a high-fat diet streptozocin. The levels fasting blood glucose (FBG), total cholesterol (TC), triglyceride (TG) serum...
Introduction: P2X7R excitation-interrelated NLRP3 inflammasome activation induced by high glucose contributes to the pathogenesis of diabetic retinopathy (DR). Relaxin-3 is a bioactive peptide with structure similar insulin, which has been reported be effective in cardiomyopathy models vivo and vitro . However, it not known whether relaxin-3 beneficial impact on DR, underlying mechanisms effect are also remain unknown. Methods Results: The retinas male streptozotocin (STZ)-induced...
Men with type 2 diabetes (T2D) and obesity are often characterised by low testosterone (T). We aimed to determine whether exenatide (EXE) combined metformin (MET) treatment has a better effect on serum total (TT) levels than glimepiride (GLI) MET in men T2D obesity. In multicentre, 12-week observational study, 176 obese failed glycaemic control were included the study: ninety (mean age, 43.00 ± 8.50 years) EXE + group 86 44.00 7.00 GLI group. Serum TT more significantly increased (121.72...
Introduction We aimed to evaluated the effect of premixed insulin (Ins), combined with metformin (Ins+Met) or mulberry twig alkaloids(Ins+SZ-A) on blood glucose fluctuations in patients type 2 diabetes (T2DM) using continuous monitors (CGM). Methods Thirty T2DM and poor control drugs were for eligibility during screening period. Subsequently, their original hypoglycemic discontinued lead-in period, after receiving Ins intensive treatment weeks, they randomly assigned receive either Ins,...
Transient receptor potential canonical (TRPC) channels, as important membrane proteins regulating intracellular calcium (Ca2+i) signaling, are involved in a variety of physiological and pathological processes. Activation regulation TRPC more dependent on or signals. However, how extracellular signals regulate TRPC6 function remains to be further investigated. Here, we suggest that two distinct small molecules, M085 GSK1702934A, directly activate TRPC6, both through mechanism stimulation...
Retinal pericyte migration occurs in the early stage of diabetic retinopathy (DR), which is one important causes loss. Autophagy has been found to play essential roles regulation many types cell migration. In this study, we explored relationship between autophagy and retinal rats, retinas became thinner, level each layer increased. primary culture bovine pericytes, that advanced glycation end products (AGEs) increased migratory ability without influencing viability, also phosphorylation...
Background. Diabetic retinopathy (DR) is the most important manifestation of diabetic microangiopathy. It essential to explore gene regulatory relationship and genomic variation disturbance biological networks in DR progression. Methods. In this study, we constructed a comprehensive lncRNA-mRNA ceRNA network procession (CLMN) explored its topological characteristics. Results. Modular functional analysis indicated that organization CLMN performed fundamental specific functions diabetes...
P2X receptors are a class of nonselective cation channels widely distributed in the immune and nervous systems, their dysfunction is significant cause tumors, inflammation, leukemia, diseases. P2X7 unique member receptor family with many properties that differ from other subtypes terms primary sequence, architecture N- C-terminals, channel function. Here, we suggest observed lengthened β2- β3-sheets linker (loop β2,3), encoded by redundant sequences, play an indispensable role activation...
Highly conserved amino acids are generally anticipated to have similar functions across a protein superfamily, including that of the P2X ion channels, which gated by extracellular ATP. However, whether and how these becomes less clear when neighboring not conserved. Here, we investigate one such case, focused on highly residue from P2X4, E118 (rat P2X4 numbering, rP2X4), subtype associated with human neuropathic pain. When compared crystal structures those other subtypes, P2X3, P2X7, AmP2X,...
The FK506 Binding Protein (FKBP), ubiquitously present across diverse species, is characterized by its evolutionarily conserved binding domain (FKBd). In plants, evidence suggests that this gene family plays integral roles in regulating growth, development, and responses to environmental stresses. Notably, research on the identification functionality of FKBP genes rice remains limited. Therefore, study utilized bioinformatic tools identify 30 FKBP-encoding rice. It provides a detailed...
Human microglia (HMC) are stress-induced inflammatory cells of the retina. It is unknown whether severe hypoglycaemia causes inflammation in microglia, affects permeability human retinal microvascular endothelial (HRMECs), and damage. This study aimed to explore effects on microglial cell evaluate damage caused by The CCK-8 assay was used measure viability. Western blotting detect IL-1β, IL-6, TNF- α, claudin-1, occludin expression. ELISA α. Transmission electron microscopy (TEM)...
Objective To investigate the effects of liraglutide on high glucose induced retinal ganglion cells injury and explore potential mechanisms. Methods RGC-5 were cultured in vitro divided into following groups: control group, glucose+liraglutide glucose+liraglutide+rapamycin glucose+rapamycin glucose+normal small interfering RNA (NC siRNA) glucose+optineurin (OPTN) siRNA group. Cell viability was detected with CCK-8 kit. LC3A/B, Beclin-1, p62 OPTN examined via western blotting analysis....
糖尿病视网膜病变（diabetic retinopathy, DR）是导致成人失明的主要原因之一，严重威胁糖尿病患者生存质量。如何早防早治以减少DR的失明风险，是目前学界关注的重点。近年来，DR相关机制的研究、检查手段的更新与治疗药物的探索为其早期防治提供了广阔的前景。本文聚焦神经血管耦合形成的精密网络，整合神经血管单元多角度认识糖尿病视网膜病变。从机制、检查、治疗等三方面总结预测与治疗微血管病变的可行性方案，以期为DR的全程、多层次优化管理提供方向。