A5101689294- Sirtuins and Resveratrol in Medicine
- Circadian rhythm and melatonin
- Autophagy in Disease and Therapy
- Cancer-related molecular mechanisms research
- Cardiac Ischemia and Reperfusion
- Adipose Tissue and Metabolism
- Adenosine and Purinergic Signaling
- Sleep and related disorders
- Sleep and Wakefulness Research
- Inflammasome and immune disorders
- PI3K/AKT/mTOR signaling in cancer
- Histone Deacetylase Inhibitors Research
- MicroRNA in disease regulation
- Cardiac, Anesthesia and Surgical Outcomes
- Lipid metabolism and disorders
- Neurological Disease Mechanisms and Treatments
- Ferroptosis and cancer prognosis
- Circular RNAs in diseases
- Heme Oxygenase-1 and Carbon Monoxide
- Mitochondrial Function and Pathology
- Gout, Hyperuricemia, Uric Acid
- Cardiac and Coronary Surgery Techniques
Renmin Hospital of Wuhan University
2019-2023
Wuhan University
2019-2023
Diabetes aggravates myocardial ischemia-reperfusion (I/R) injury because of the combination effects changes in glucose and lipid energy metabolism, oxidative stress, systemic inflammatory response. Studies have indicated that I/R may coincide interact with sepsis inflammation. However, role LPS hypoxia/reoxygenation (H/R) cardiomyocytes under high conditions is still unclear. Our objective was to examine whether lipopolysaccharide (LPS) could aggravate glucose- (HG-) hypoxia/reoxygenation-...
Abstract The circadian clock is closely related to the development of diabetes mellitus and cardiovascular disease, disruption exacerbates myocardial ischaemia/reperfusion injury (MI/RI). HDAC3 a key component negative feedback loop that controls expression pattern nuclear receptor Rev-erbα maintain stability genes such as BMAL1. However, mechanism by which HDAC3-orchestrated Rev-erbα/BMAL1 pathway increases MI/RI in its relationship with mitophagy have yet be elucidated. Here, we observed...
Type 2 diabetic hearts are more vulnerable to myocardial ischemia reperfusion (MIR) injury, which involves decreased mitophagy status with unknown mechanisms. MitoQ, a mitochondria-targeted antioxidant, has been shown have protection against injury through upregulating mitophagy. The aim of this study was investigate the effects MitoQ on myocardium during MIR in type diabetes (T2D). Herein, discovered that PINK1/Parkin downregulation suffered accompanied by reduced Treatment significantly...
Imatinib is a classical targeted drug to treat chronic myeloid leukemia (CML). However, it shows cardiotoxicity, which limits its clinical application. Long noncoding RNA (lncRNA) maternally expressed gene 3 (MEG3) proapoptotic properties in human cells. This study performed investigate whether targeting MEG3 can attenuate imatinib‐mediated cardiotoxicity cardiomyocytes. In this work, H9c2 cells were divided into four groups: control group, hypoxia + imatinib, and imatinib knockdown group....
In this paper, we have carried out an experimental study to investigate the effects of different anesthetics on perioperative organ protection and postoperative cognitive function in patients undergoing cardiac valve replacement with cardiopulmonary bypass. To realize idea, a total 90 single under general anesthesia hypothermic bypass from January 2020 October 2021 were enrolled. These assigned into three groups, 30 cases each group by digital table method. Group A was anesthetized...
Abstract Background: Circadian clock has been closely related to the development of diabetes mellitus and cardiovascular disease; disruption circadian exacerbates myocardial ischemia/reperfusion injury (MI/RI). HDAC3 is a key component negative feedback loop by recruitmenting expression pattern nuclear receptor Rev-erbα, then maintain stability gene such as BMAL1. In this research, we explored mechanism HDAC3-orchestrated Rev-erbα/BMAL1 pathway in increasing MI/RI vulnerability diabetes, its...
Objective To investigate the effects of liraglutide on high glucose induced retinal ganglion cells injury and explore potential mechanisms. Methods RGC-5 were cultured in vitro divided into following groups: control group, glucose+liraglutide glucose+liraglutide+rapamycin glucose+rapamycin glucose+normal small interfering RNA (NC siRNA) glucose+optineurin (OPTN) siRNA group. Cell viability was detected with CCK-8 kit. LC3A/B, Beclin-1, p62 OPTN examined via western blotting analysis....
Objective To evaluate the role of nuclear factor erythroid 2-related 2 (Nrf2)-glutathione peroxidase 4 (GPX4) signaling pathway in Shenmai injection-induced reduction myocardial ischemia-reperfusion (I/R) injury and relationship with ferroptosis rats. Methods Forty-eight SPF healthy adult male Sprague-Dawley rats, weighing 220-250 g, were divided into groups (n=12 each) by a random number table method: sham operation group (S group), I/R (IR injection (SM plus Nrf2 inhibitor (SMM...
Objective To evaluate the role of histone deacetylase 3 (HDAC3) in renal injury induced by myocardial ischemia-reperfusion (I/R) diabetic rats. Methods SPF healthy adult male Sprague-Dawley rats, weighing 210-220 g, were used this study.Diabetes mellitus was intraperitoneal injection 1% streptozotocin 60 mg/kg.Eighteen rats divided into groups (n=6 each) using a random number table method: sham operation group (group S), I/R and HDAC3 inhibitor RGFP966 (RG). The model established...
Background: Circadian clock has been closely related to the development of diabetes mellitus and cardiovascular disease; disruption circadian exacerbates myocardial ischemia/reperfusion injury (MI/RI). HDAC3 is a key component negative feedback loop by recruitmenting expression pattern nuclear receptor Rev-erbα, then maintain stability gene such as BMAL1. In this research, we explored mechanism HDAC3-orchestrated Rev-erbα/BMAL1 pathway in increasing MI/RI vulnerability diabetes, its...