A5101675190- Colorectal Cancer Treatments and Studies
- Colorectal Cancer Surgical Treatments
- Gastric Cancer Management and Outcomes
- Colorectal and Anal Carcinomas
- Lung Cancer Research Studies
- Neuroendocrine Tumor Research Advances
- Cancer Immunotherapy and Biomarkers
- Pancreatic and Hepatic Oncology Research
- Neuroblastoma Research and Treatments
- Radiomics and Machine Learning in Medical Imaging
- Gastrointestinal Tumor Research and Treatment
- Genetic factors in colorectal cancer
- Polyomavirus and related diseases
- Cancer Genomics and Diagnostics
- Inflammatory Biomarkers in Disease Prognosis
- Protein Degradation and Inhibitors
- Plant Virus Research Studies
- Immune cells in cancer
- DNA Repair Mechanisms
- Hepatocellular Carcinoma Treatment and Prognosis
- Ferroptosis and cancer prognosis
- Bone Tissue Engineering Materials
- Cancer-related molecular mechanisms research
- Ubiquitin and proteasome pathways
- Cholangiocarcinoma and Gallbladder Cancer Studies
Union Hospital
2016-2025
Huazhong University of Science and Technology
2016-2025
Shanghai Sixth People's Hospital
2025
Fujian Medical University
2025
Chinese Academy of Medical Sciences & Peking Union Medical College
2023-2024
China Medical University
2024
Fourth Affiliated Hospital of China Medical University
2024
Integrated Chinese Medicine (China)
2023-2024
First Hospital of China Medical University
2024
Wuhan Union Hospital
2019-2023
Background In locally advanced rectal cancer (LARC), preoperative short-course radiotherapy (SCRT) with delayed surgery has been shown to be as effective long-course chemoradiotherapy, only modest benefits. This study aimed evaluate the efficacy and safety of SCRT combined subsequent CAPOX (capecitabine oxaliplatin) anti-PD-1 antibody camrelizumab in patients LARC. Methods was a prospective, single-arm, phase II trial. Treatment-naïve histologically confirmed T3-4N0M0 or T1-4N+M0...
Abstract Background and Aims Metastasis is the primary cause of cancer mortality, colorectal (CRC) frequently metastasizes to liver. Our previous studies demonstrated critical role KIAA1199 in tumor invasion metastasis CRC. In present study, we described an immune regulatory effect that creates a permissive environment for metastasis. Approach Results Flow cytometry was used examine effects on infiltration cells. Neutrophils T cells were isolated, stimulated, and/or cultured vitro function...
Loss of major histocompatibility complex class I (MHC-I) in tumor cells limits the use immune checkpoint blockade (ICB) colorectal cancer. Nevertheless, regulatory mechanism MHC-I downregulation has not been fully elucidated. Overexpression CEMIP tissues is associated with a poor prognosis Here, this research, we aim to address role mediating expression and investigate underlying mechanisms.Protein levels were analyzed by western blotting. Flow cytometry analysis was used examine cells....
Abstract Merkel cell carcinoma (MCC) is an aggressive neuroendocrine tumor of the skin currently with no cure. In this study, we have first demonstrated that c-Myc overexpression common in MCC. By targeting c-Myc, bromodomain inhibitors antitumor efficacy several preclinical human cancer models. Thus, interrogated role inhibition MCC amplification by using BET inhibitor JQ1. We uncovered can be regulated JQ1 cells pathologic activation. Moreover, potently abrogates expression and causes...
Abstract Background The cyclin-dependent kinase 7 (CDK7) subunit of TFIIH regulates RNA polymerase-II-based transcription and promotes tumor progression. However, the mechanisms involved in CDK7-mediated immune evasion are unclear non-small cell lung cancer (NSCLC). Methods silencing pharmacologic inhibitors were used to evaluate functions CDK7/p38α/MYC/PD-L1 axis proliferation antiPD-1 therapy resistance. Flow cytometry was performed detect status microenvironment after CDK7 inhibition...
The gut microbiome plays an indispensable role in the occurrence and progression of various diseases. However, its ability to predict gastric cancer (GC) liver metastasis (GCLM) has not been fully identified.
While radiotherapy continues to be a major cancer treatment option, its dose-limiting side effects, such as pulmonary fibrosis, severely impair the quality of life in these patients. In this study, we evaluated radioprotective effects metformin, commonly used biguanide antidiabetic medication, murine model damage. Sprague Dawley® rats received whole lung 20 Gy irradiation with or without metformin treatment. Computed tomography (CT) was performed and Hounsfield units (HU) were determined...
407 Background: Preliminary results of the open-label, single-arm phase II study (NCT05625737) had demonstrated combination fruquintinib and sintilimab as a second-line therapy promising anti-tumor activity an acceptable safety profile in pts with advanced GC/GEJC (ASCO-GI 2024. Poster 332). Here, we update focus on subgroup analyses. Methods: Patients (pts) aged 18-75 years who were HER2-negative failed first-line standard treatment enrolled. Eligible received 4mg orally once daily days...
Background Despite advancements in treatment modalities, several patients with colorectal cancer (CRC) remain unresponsive to immune checkpoint inhibitor therapy. Pyroptosis, an inflammatory programmed cell death process, holds substantial promise for tumor immunotherapy. In this study, we explored the use of pyroptosis overcome immunotherapy resistance CRC. Methods We used a pyroptosis-related gene panel construct efficacy evaluation model and validated its performance by...
To study the relationship between red blood cell distribution width (RDW) and short-term mortality of hip fracture in middle-aged older adults. A retrospective cohort electronic medical records at a single hospital over 2-year period 2020 2021. We received 233 patients aged > 50 years who suffered from fracture. clinical data including demographics, comorbidities time admission, type surgery, examination, 3-months mortality, 6-months 1-year mortality. RDW were analyzed. was then divided into...
Radiation-induced lung injury has restricted radiotherapy for thoracic cancer. The purpose of this study was to investigate the radioprotective effects bromodomain and extra terminal (BET) inhibitor JQ1 in a murine model pulmonary damage. Chest computed tomography (CT) performed rat after 20 Gy radiation right thorax. And histological evaluation protein expressions irradiated tissue were analyzed confirm potential anti-fibrosis effect its underlying mechanisms. Moreover, colony formation...
Background: The prognostic value of neutrophil-to-lymphocyte ratio (NLR) and monocyte-to-lymphocyte (MLR) in metastatic gastric cancer (mGC) treated with systemic chemotherapy is largely unknown, especially second-line chemotherapy. We retrospectively investigated the baseline NLR MLR progression mGC Methods: Patients diagnosed by pathology from January 2010 to December 2018 were identified. Baseline collected before treatment. time during or after first-line therapy diagnosis (PFS1), (PFS2)...
CRC (Colorectal cancer) is one of the most common causes death worldwide and in US (United States).In this study, we aim to perform a population-based analysis on cause among patients with US.A total 834,510 diagnosed between 1975 2016 were selected from SEER (Surveillance, Epidemiology, End Results) program.Causes characterized SMRs (standardized mortality ratios) non-cancer calculated.Among all included 531,507 deaths recorded, which 51.3% due CRC, 10.3% other cancers, 38.4%...
Radiation-induced brain injury (RIBI) is a serious complication in cancer patients receiving radiotherapy, and accumulating evidence suggests that microglial activation plays an important role its pathogenesis. Fractalkine (FKN) crucial mediator responsible for the biological activity of microglia. In this study, effect FKN on activated after irradiation RIBI was explored underlying mechanisms were investigated. Our study demonstrated treatment with exogenous diminished radiation-induced...
Abstract Metastasis is the leading cause of treatment failure and tumor-related death in colorectal cancer (CRC). Our previous studies report that CEMIP functionally promotes CRC metastasis closely related to poor outcomes. However, molecular network promoting still not fully understood. In current study, we identify interacting with GRAF1, combination high-CEMIP low-GRAF1 predicts survival patients. Mechanistically, elucidate interacts SH3 domain GRAF1 through 295–819aa domain, negatively...
Merkel cell carcinoma (MCC) is an aggressive neuroendocrine skin cancer. Pathologic activation of PI3K/mTOR pathway and elevated expression c-Myc are frequently detected in MCC. Yet, there no targeted therapy presently available for this lethal disease. Recently, MLN0128, a second-generation dual TORC1/2 inhibitor shown to have therapeutic efficacy preclinical studies. MLN0128 currently clinical trials as potential advanced cancers. Here we characterize the setting MCC delineate downstream...