A5101579171- MicroRNA in disease regulation
- Lung Cancer Research Studies
- Neuroendocrine Tumor Research Advances
- Pancreatic and Hepatic Oncology Research
- Colorectal Cancer Treatments and Studies
- Gastric Cancer Management and Outcomes
- Colorectal Cancer Surgical Treatments
- Herpesvirus Infections and Treatments
- Alzheimer's disease research and treatments
- Neuroblastoma Research and Treatments
- Cancer Immunotherapy and Biomarkers
- Colorectal and Anal Carcinomas
- Genetic factors in colorectal cancer
- Respiratory viral infections research
- Esophageal and GI Pathology
- Virology and Viral Diseases
- Immune cells in cancer
- Viral Infections and Immunology Research
- Metal-Organic Frameworks: Synthesis and Applications
- Endometrial and Cervical Cancer Treatments
- Colorectal Cancer Screening and Detection
- Neonatal Respiratory Health Research
- Cardiac, Anesthesia and Surgical Outcomes
- Vaccine Coverage and Hesitancy
- Cancer Mechanisms and Therapy
Zhejiang University
2008-2025
Union Hospital
2018-2025
Huazhong University of Science and Technology
2018-2025
Sir Run Run Shaw Hospital
2008-2025
Gansu Great Wall Electrical and Electronics Engineering Research Institute
2024
Xuzhou Medical College
2018-2023
First Affiliated Hospital of Soochow University
2018-2023
Soochow University
2018-2023
Beijing Center for Disease Prevention and Control
2013-2023
Jiangsu University
2020-2022
Shaping up your clusters: Two supramolecular clusters of multiple lanthanide helicates have been synthesized. Cluster structure is controlled by the choice anion, with tetrahedral ClO4− producing larger circular helicates, and trigonal-planar NO3− leading to a compact quadruple-stranded helicate (see picture).
Extrusion of neutrophil extracellular traps (NETs), a fundamental host innate immune defense against pathogens, has recently been linked to cancer resistance immunotherapy and distant metastasis. These findings highlight interesting areas cancer-elicited inflammation potential therapeutic strategies. Disrupting existing NETs with DNase I proved enhance the efficacy tumor attenuate metastatic spread. However, systemic biodistribution raises safety issues, potentially impairing infection....
Abstract Background and Aims Metastasis is the primary cause of cancer mortality, colorectal (CRC) frequently metastasizes to liver. Our previous studies demonstrated critical role KIAA1199 in tumor invasion metastasis CRC. In present study, we described an immune regulatory effect that creates a permissive environment for metastasis. Approach Results Flow cytometry was used examine effects on infiltration cells. Neutrophils T cells were isolated, stimulated, and/or cultured vitro function...
Loss of major histocompatibility complex class I (MHC-I) in tumor cells limits the use immune checkpoint blockade (ICB) colorectal cancer. Nevertheless, regulatory mechanism MHC-I downregulation has not been fully elucidated. Overexpression CEMIP tissues is associated with a poor prognosis Here, this research, we aim to address role mediating expression and investigate underlying mechanisms.Protein levels were analyzed by western blotting. Flow cytometry analysis was used examine cells....
To explore the experience of tumor control technique in robot-assisted laparoscopic bladder diverticulectomy (RALBD) treatment diverticulum tumor, intraoperative and postoperative comprehensive treatment. We treated three male patients with tumors. Case 1 involved a 63-year-old 3.0 cm on right wall. 2 70-year-old 1.0 cauliflower-like left 3 64-year-old Each patient underwent partial cystectomy (PC) ureteral Double J (D-J) stent placement. minimize risk spread, we implemented enhanced...
Mitochondria damage exacerbates NAFLD through trigerring AIM2 inflammasome activation and hepatocyte pyroptosis. This study provides novel insights into the underlying mechanisms of mitochondrial DNA synthesis in also suggests potential therapeutic targets for treatment NAFLD.
Abstract Introduction Gelsolin is an actin-binding plasma protein that part of 'actin-scavenging' system. Studies suggest gelsolin may play a crucial role in the pathophysiology sepsis. Little known about course levels over time patients with severe The aim study was to investigate septic and determine whether these predict severity or clinical outcome Methods Ninety-one who were diagnosed sepsis at admission surgical intensive care unit enrolled, recorded. Plasma recorded daily 23 patients....
Objective The reliability and validity of the Chinese version neuropsychiatric inventory (CNPI) in patients with Alzheimer's disease (AD) have not been assessed mainland China. We do research about CNPI China present study. Methods was administered to 219 caregivers AD. Each caregiver retested 4 weeks after initial testing. Results Cronbach's α coefficient total symptom scale 0.69. distress subscale 0.72. entire 0.82. test–retest coefficients ranged from 0.66 0.98 ( p < 0.001). Principal...
CRC (Colorectal cancer) is one of the most common causes death worldwide and in US (United States).In this study, we aim to perform a population-based analysis on cause among patients with US.A total 834,510 diagnosed between 1975 2016 were selected from SEER (Surveillance, Epidemiology, End Results) program.Causes characterized SMRs (standardized mortality ratios) non-cancer calculated.Among all included 531,507 deaths recorded, which 51.3% due CRC, 10.3% other cancers, 38.4%...
Human neutrophil peptides 1-3 are endogenous cationic antimicrobial implicated in host defense against microbes. The genes encoding human (DEFA1/DEFA3) exhibit copy number variations. This study was designed to determine whether DEFA1/DEFA3 variations conferred susceptibility infection-induced complications such as severe sepsis.This case-control performed 179 patients with sepsis and 233 healthy blood donors replicated an independent cohort of 112 cases 118 controls. Plasma levels 1-3,...
Purpose . To assess the incidence of postoperative pulmonary complications (PPCs) in Chinese inpatients, and to develop a brief predictive risk index. Methods Between August 6, 2012, 12, patients undergoing noncardiac operations four university hospitals were enrolled. The cohort was divided into two subsamples, 1 index PPCs 2 validate it. Results 1673 recorded for 163 (9.7%), whom hospital length stay (LOS) longer (<mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML"...
Background Transfusion‐transmitted babesiosis caused by B abesia microti has emerged as a significant risk to the US blood supply. This study estimated prevalence of . antibodies in donors using an investigational enzyme immunoassay ( EIA ). Study Design and Methods A peptide‐based that detects both immunoglobulin Ig ) G IgM was developed validated. Donor samples randomly selected from areas defined high‐risk endemic, lower‐risk nonendemic for were deidentified tested Samples repeat reactive...
A 65-year-old man was admitted to our hospital with a 2-month history of pain in the right abdomen and intermittent watery diarrhea. He had previously been good health not traveled tropics recent years. On examination, mild tenderness noted on palpation over abdomen. The results his blood tests were as follows: white cell count (WBC) 7.7 × 109/L, neutrophils 78.5 %, red (RBC) 3.56 1012/L, hemoglobin (Hb) 104 g/L, erythrocyte sedimentation rate (ESR) 23 mm/h. fecal occult test positive.
Abstract Introduction Fungal infection is increasingly common in critical illness with severe sepsis, but the influence of invasive fungal (IFI) on sepsis not well understood. The aim this study was to investigate impact that IFI has outcomes critically ill surgical patients China by means matched cohort analysis; we also evaluated epidemiologic characteristics population. Methods Records for all admissions 10 university hospital intensive care units (ICUs) from December 2004 November 2005...
Recent studies have emphasized determining the ability of microRNAs (miRNAs) as crucial regulators in occurrence and development pancreatic cancer (PC), which continues to be one deadliest malignancies with few effective therapies. The study aimed investigate functional role miR-135b its associated mechanism unravel biological characteristics tumor growth stem cells (PCSCs).Microarray analyses were initially performed identify PC-related miRNAs genes. expression PCSC markers PC tissues was...
Abstract Background: The World Health Organization (WHO) has endorsed school bystander cardiopulmonary resuscitation (CPR) training programs. But related researches in China are limited. Therefore, we conducted this study to assess CPR children and the impact of neighborhood socio-economic status (SES) on. Methods: A total 1,093 students from seven schools Zhejiang province participated study. Theoretical practical were instructor-led classes. Students completed a 10-statement questionnaire...