A5025018187- Antimicrobial Peptides and Activities
- Biochemical and Structural Characterization
- Cardiac Arrest and Resuscitation
- Biofuel production and bioconversion
- Forest Biomass Utilization and Management
- Trauma and Emergency Care Studies
- Bacteriophages and microbial interactions
- China's Socioeconomic Reforms and Governance
- Sepsis Diagnosis and Treatment
- Polydiacetylene-based materials and applications
- Sharing Economy and Platforms
- Trauma Management and Diagnosis
- Photovoltaic Systems and Sustainability
- Cell death mechanisms and regulation
- Lipid Membrane Structure and Behavior
- Mechanical Circulatory Support Devices
- Hemoglobinopathies and Related Disorders
- Iron Metabolism and Disorders
- Bioenergy crop production and management
- Apelin-related biomedical research
- Inflammation biomarkers and pathways
- Cytokine Signaling Pathways and Interactions
- Sphingolipid Metabolism and Signaling
- Streptococcal Infections and Treatments
- Extracellular vesicles in disease
Shandong Normal University
2024
Zhejiang University
2018-2024
Xuzhou University of Technology
2024
National Clinical Research
2024
First Affiliated Hospital Zhejiang University
2021-2023
Hebei Medical University
2020
Peking University
2020
Committee on Publication Ethics
2018
Sir Run Run Shaw Hospital
2018
Northeast Forestry University
2013
The increasing prevalence of antibacterial resistance globally underscores the urgent need to update antibiotics. Here, we describe a strategy for inducing self-assembly host-defense antimicrobial peptide (AMP) into nanoparticle antibiotics (termed nanobiotics) with significantly improved pharmacological properties. Our involves myristoylation human α-defensin 5 (HD5) as therapeutic target and subsequent in aqueous media absence exogenous excipients. Compared its parent HD5, C-terminally...
SignificanceWe report the development of peptidomimetic antibiotics derived from a natural antimicrobial peptide, human α-defensin 5. By engaging multiple bacterial targets, lead compound is efficacious in vitro and vivo against bacteria with highly inducible antibiotic resistance, promising useful therapeutic agent for treatment infections caused by antibiotic-resistant bacteria.
Abstract What We Already Know about This Topic Article Tells Us That Is New Background Pyroptosis, a type of proinflammatory programmed cell death, drives cytokine storm. Caspase-11–dependent macrophage pyroptosis contributes to mortality during sepsis. Sphingosine-1-phosphate receptor 2 (S1PR2) signaling can amplify interleukin-1β secretion in endotoxin-induced inflammation. Here, we hypothesized that S1PR2 increases caspase-11–dependent and worsens Gram-negative sepsis outcome. Methods A...
Background: Host defense peptides (HDPs) have emerged as a novel therapeutic paradigm for wound management; however, their clinical applications remain challenge owing to poor pharmacological properties and lack of suitable pharmaceutical formulations. Nanodefensin (ND), nanoengineered human α-defensin 5 (HD5), has shown improved relative the parent compound. In this study, we engineered nanodefensin-encased hydrogel (NDEFgel), investigated effects NDEFgel on healing, elucidated underlying...
Abstract Background: The World Health Organization (WHO) has endorsed school bystander cardiopulmonary resuscitation (CPR) training programs. But related researches in China are limited. Therefore, we conducted this study to assess CPR children and the impact of neighborhood socio-economic status (SES) on. Methods: A total 1,093 students from seven schools Zhejiang province participated study. Theoretical practical were instructor-led classes. Students completed a 10-statement questionnaire...
The COVID-19 pandemic threatens physical and mental health of adolescents worldwide has caused increased risks dependence addiction on Internet use during home quarantine. become an important issue in healthcare its prevention treatment is great significance for the development adolescents. We have gathered leading experts China developed this guideline to provide references suggestions prevent treat quarantine help them get through pandemic.
Endogenously produced glucocorticoids exhibit immunomodulating properties and are of pivotal importance for sepsis outcome. Uncontrolled activation the immune-adrenal crosstalk increases risk sepsis-related death. Triggering receptor expressed on myeloid cells-2 (TREM2) is richly macrophages has been demonstrated to improve outcome by enhancing elimination pathogens. However, role mode action macrophage TREM2 adrenocortical steroidogenesis remains unclear in septic shock. The acute shock...
Gram-negative sepsis has become a substantial and escalating global healthcare challenge due to the growing antibiotic resistance crisis sluggish development of new antibiotics. LL-37, unique Cathelicidin species found in humans, exhibits wide range bioactive properties, including direct bactericidal effects, inflammation regulation, LPS neutralization. KR-12, smallest yet potent peptide fragment been modified create more effective antimicrobials. In this study, we designed two myristoylated...
Acute respiratory distress syndrome (ARDS) is a common lung disorder that involves severe inflammatory damage in the pulmonary barrier, but underlying mechanisms remain elusive. Here, we demonstrated macrophages originating from ARDS patients and mice caused by bacteria were characterized increased expression of ferroportin (FPN). Specifically deleting FPN myeloid cells conferred significant resistance to bacterial infection with improved survival decreasing extracellular growth preserving...
To the Editor: Early bystander cardiopulmonary resuscitation (CPR) is crucial for survival and long-term quality of life patients with out-of-hospital cardiac arrest.[1] Training schoolchildren how to perform CPR highly recommended by many countries health organizations, including World Health Organization.[2,3] Schoolteachers previous training are suggested as instructors teach schoolchildren.[4,5] The knowledge teachers very important their willingness teaching.[6,7] A 6-year longitudinal...
BACKGROUND: Streptococcus pneumoniae (S. pneumoniae) is a common pathogen that causes bacterial pneumonia.However, with increasing resistance, there an urgent need to develop new drugs treat S. infections.Nanodefensin 14-carbon saturated fatty acid (ND-C14) novel nanoantimicrobial peptide designed by modifying myristic at the C-terminus of human α-defensin 5 (HD5) via amide bond.However, it unclear whether ND-C14 effective against lung infections caused pneumoniae. METHODS:In vitro, three...
With the development of Chengdu's night economy, internet-famous street food stalls have become nationally famous and a symbol tourism entertainment. Under influence COVID-19, more middle low-level urban migrant workers are becoming unemployed. However, as city for its market, stallholder operation finds another new way unemployed to make business. This article will focus on current situation market bazaar-type economy in Chengdu under background factors influencing economy. Therefore, by...
This study investigates the impact of career incentives local leaders on China's residential land transfer. It constructs measure by utilizing a large resume dataset 1266 city in 292 Chinese cities from 2000 to 2014 according method used Wang et al. (2019). Matching data with transfer 2006 46 cities, our empirical results show that one-standard-deviation increase leader's incentive will lead 12.29% decrease area, 27.35% price, 20.05% revenue and 2.99% ratio areas transferred through auction...
Abstract Gram-negative sepsis has become one of major increasing medical burdens globally, which is subjected to growing antibiotic resistance problem and the relatively delayed development new antibiotics. LL-37, only type Cathelicidin identified in humans, diverse biological activities including direct bactericidal action, regulation inflammation LPS-neutralization. The KR-12 peptide smallest portion LL-37 with antibacterial been shown that could be modified into more effective...
Objective To study the effects of myristoyl-glycine modified peptide which derived from second intracellular loop sphingosine 1-phosphate receptor 3 (S1PR3) on activation mitogen-activated protein kinases (MAPKs) pathway. Methods The phosphorylation levels JNK and ERK in THP-1 cells were detected by western blot after GPS-725.017 stimulation. Statistical data analysis was conducted multivariate variance. Results Western showed that 10 min 30 μmol/L or 50 stimulated,...