A5081212350- Sepsis Diagnosis and Treatment
- Cardiac, Anesthesia and Surgical Outcomes
- Antimicrobial Peptides and Activities
- Immune Response and Inflammation
- Inflammation biomarkers and pathways
- Enhanced Recovery After Surgery
- Neonatal Respiratory Health Research
- Trauma, Hemostasis, Coagulopathy, Resuscitation
- Neonatal and Maternal Infections
- Immune cells in cancer
- Intensive Care Unit Cognitive Disorders
- Anesthesia and Sedative Agents
- Hemodynamic Monitoring and Therapy
- Lung Cancer Diagnosis and Treatment
- Pancreatitis Pathology and Treatment
- Nosocomial Infections in ICU
- Nutrition and Health in Aging
- Autophagy in Disease and Therapy
- Traumatic Brain Injury and Neurovascular Disturbances
- Anesthesia and Pain Management
- Mesenchymal stem cell research
- Spine and Intervertebral Disc Pathology
- Respiratory Support and Mechanisms
- Liver Disease and Transplantation
- Airway Management and Intubation Techniques
Zhejiang University
2015-2025
First Affiliated Hospital Zhejiang University
2009-2023
Children's Hospital of Zhejiang University
2021
Second Affiliated Hospital of Dalian Medical University
2020
Dalian Medical University
2020
Sir Run Run Shaw Hospital
2011-2018
Committee on Publication Ethics
2018
Shanghai Institute of Materia Medica
2015
Chinese Academy of Sciences
2015
Recent studies have demonstrated that mesenchymal stem cells (MSCs) modulate the immune response and reduce lung injury in animal models. Currently, no clinical of effects MSCs acute respiratory distress syndrome (ARDS) exist. The objectives this study were first to examine possible adverse events after systemic administration allogeneic adipose-derived ARDS patients second determine potential efficacy on ARDS. Twelve adult meeting Berlin definition with a PaO2/FiO2 ratio < 200 randomized...
Sepsis is a leading cause of death in critical illness, and its pathophysiology varies depending on preexisting medical conditions. Here we identified nonalcoholic fatty liver disease (NAFLD) as an independent risk factor for sepsis large clinical cohort showed link between mortality NAFLD-associated hepatic mitochondrial energetic metabolism dysfunction. Using vivo vitro models lipid overload, discovered metabolic coordination hepatocyte mitochondria macrophages that express triggering...
Objectives: To determine the occurrence rate, outcomes, and characteristics of severe sepsis in surgical intensive care units multiple medical centers within China to assess cost resource use China. Design Setting: Prospective, observational study unit patients at ten university hospitals six provinces Patients: All adult admissions studied from December 1, 2004, November 30, 2005. Interventions: None. Measurements Main Results: The criteria were based on American College Chest...
The increasing prevalence of antibacterial resistance globally underscores the urgent need to update antibiotics. Here, we describe a strategy for inducing self-assembly host-defense antimicrobial peptide (AMP) into nanoparticle antibiotics (termed nanobiotics) with significantly improved pharmacological properties. Our involves myristoylation human α-defensin 5 (HD5) as therapeutic target and subsequent in aqueous media absence exogenous excipients. Compared its parent HD5, C-terminally...
Triggering receptor expressed on myeloid cells-2 (TREM-2) is a cell surface primarily macrophages and monocyte-derived cells. TREM-2 not only functions as regulator of inflammatory response, but also serves phagocytic for bacteria. However, the role in sepsis remains unknown.To investigate whether plays sepsis.The manner expression was evaluated patients with polymicrobial septic mouse model induced by cecum ligation puncture approach. Recombinant used to block effect TREM-2. Bone...
Sepsis is a leading cause of death in critically ill patients, and apoptosis plays major role the pathophysiology sepsis. Elevated levels circulating nucleosomes released by apoptotic cells have been detected patients with severe sepsis septic shock. The aim this study was to evaluate diagnostic/prognostic value sepsis.Seventy-four newly admitted an estimated length stay intensive care unit more than 48 h, were prospectively enrolled as cohort 1. second independent (cohort 2) consisted 91...
Inflammatory and immune responses, as well melatonin secretion, are affected by circadian regulation. Abnormal rhythm of release has been reported to be associated with the later stages sepsis; however, its role in early sepsis is unclear. We studied 11 septic non-septic patients our intensive care unit (ICU). Peripheral blood was drawn at 4-h intervals on first day, beginning 2:00 p.m., over a total period 24 h. Plasma levels melatonin, tumor necrosis factor α (TNF-α) interleukin 6 (IL-6)...
Abstract Background: Sepsis is characterized by an inappropriate systemic inflammatory response and bacteremia that promote multiorgan failure mortality. Sphingosine 1-phosphate receptor 2 (S1PR2) modulates endotoxin-induced inflammation in endothelium. However, as a highly expressed S1P macrophages, its role regulating macrophage to bacterial infection remains unclear. Methods: Cecal ligation puncture or intratracheal instillation of Escherichia coli was induced wild-type S1pr2-deficient...
To compare the effects of dexmedetomidine and propofol on sublingual microcirculation in patients after cardiac surgery.A prospective, randomized, single-blind study.University hospital.Adult undergoing elective valve surgery with cardiopulmonary bypass.On arrival intensive care unit (ICU), were assigned randomly to receive either (0.2-1.5 μg/kg/h) or (5-50 μg/kg/min) open-label titration a target Richmond Agitation-Sedation Scale 0 -3.Sublingual was recorded using sidestream dark-field...
SignificanceWe report the development of peptidomimetic antibiotics derived from a natural antimicrobial peptide, human α-defensin 5. By engaging multiple bacterial targets, lead compound is efficacious in vitro and vivo against bacteria with highly inducible antibiotic resistance, promising useful therapeutic agent for treatment infections caused by antibiotic-resistant bacteria.
Abstract Introduction Gelsolin is an actin-binding plasma protein that part of 'actin-scavenging' system. Studies suggest gelsolin may play a crucial role in the pathophysiology sepsis. Little known about course levels over time patients with severe The aim study was to investigate septic and determine whether these predict severity or clinical outcome Methods Ninety-one who were diagnosed sepsis at admission surgical intensive care unit enrolled, recorded. Plasma recorded daily 23 patients....
The definition of sepsis was updated to sepsis-3 in February 2016. However, the performance previous and new remains unclear China. This a retrospective multicenter study six intensive care unit (ICUs) from five university-affiliated hospitals compare between sepsis-1 From May 1, 2016 June 2016, 496 patients were enrolled consecutively. Data extracted electronic clinical records. We evaluated by measuring area under receiver operating characteristic curves (AUROC) predict 28-day mortality...
Abstract What We Already Know about This Topic Article Tells Us That Is New Background Pyroptosis, a type of proinflammatory programmed cell death, drives cytokine storm. Caspase-11–dependent macrophage pyroptosis contributes to mortality during sepsis. Sphingosine-1-phosphate receptor 2 (S1PR2) signaling can amplify interleukin-1β secretion in endotoxin-induced inflammation. Here, we hypothesized that S1PR2 increases caspase-11–dependent and worsens Gram-negative sepsis outcome. Methods A...
Human neutrophil peptides 1-3 are endogenous cationic antimicrobial implicated in host defense against microbes. The genes encoding human (DEFA1/DEFA3) exhibit copy number variations. This study was designed to determine whether DEFA1/DEFA3 variations conferred susceptibility infection-induced complications such as severe sepsis.This case-control performed 179 patients with sepsis and 233 healthy blood donors replicated an independent cohort of 112 cases 118 controls. Plasma levels 1-3,...
Purpose . To assess the incidence of postoperative pulmonary complications (PPCs) in Chinese inpatients, and to develop a brief predictive risk index. Methods Between August 6, 2012, 12, patients undergoing noncardiac operations four university hospitals were enrolled. The cohort was divided into two subsamples, 1 index PPCs 2 validate it. Results 1673 recorded for 163 (9.7%), whom hospital length stay (LOS) longer (<mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML"...
Background: Host defense peptides (HDPs) have emerged as a novel therapeutic paradigm for wound management; however, their clinical applications remain challenge owing to poor pharmacological properties and lack of suitable pharmaceutical formulations. Nanodefensin (ND), nanoengineered human α-defensin 5 (HD5), has shown improved relative the parent compound. In this study, we engineered nanodefensin-encased hydrogel (NDEFgel), investigated effects NDEFgel on healing, elucidated underlying...
Abstract Introduction Fungal infection is increasingly common in critical illness with severe sepsis, but the influence of invasive fungal (IFI) on sepsis not well understood. The aim this study was to investigate impact that IFI has outcomes critically ill surgical patients China by means matched cohort analysis; we also evaluated epidemiologic characteristics population. Methods Records for all admissions 10 university hospital intensive care units (ICUs) from December 2004 November 2005...
Mesenchymal stem cells (MSCs) have been shown to reduce sepsis-induced inflammation and improve survival in mouse models of sepsis. CD16+ monocytes are proinflammatory abundant inflammatory conditions such as The primary objective this exploratory study was determine the effects adipose-derived MSCs (ASCs) on three subsets from sepsis patients vitro delineate underlying mechanism. This is a prospective cohort admitted medical intensive care unit (ICU) at an academic center. levels...
Both bone marrow and adipose-derived mesenchymal stem cells (ASCs) have immunomodulatory effects. The goal of this study was to determine whether ASCs-educated macrophages could directly ameliorate LPS-induced systemic response in a mouse model. Mouse peritoneal were cocultured with ASCs Transwell system for 2 days educate macrophages. Mice divided into 5 groups: control, LPS, LPS + ASCs, untreated macrophages, educated Educated decreased lung inflammation, weight loss, pulmonary edema,...