A5003926271- Antimicrobial Peptides and Activities
- Biochemical and Structural Characterization
- Neurological Complications and Syndromes
- Polydiacetylene-based materials and applications
- Pregnancy and preeclampsia studies
- Liver Disease Diagnosis and Treatment
- Pancreatitis Pathology and Treatment
- Moyamoya disease diagnosis and treatment
- Sphingolipid Metabolism and Signaling
- Sepsis Diagnosis and Treatment
- Bacteriophages and microbial interactions
- Metabolism and Genetic Disorders
- Inflammasome and immune disorders
- Pancreatic and Hepatic Oncology Research
- Thermal Regulation in Medicine
- Cardiac Arrest and Resuscitation
- Nuts composition and effects
- Bacterial biofilms and quorum sensing
- Graphene and Nanomaterials Applications
- Amino Acid Enzymes and Metabolism
- Neuropeptides and Animal Physiology
- Immune Response and Inflammation
- Supramolecular Self-Assembly in Materials
- Essential Oils and Antimicrobial Activity
- Folate and B Vitamins Research
First Affiliated Hospital of Zhengzhou University
2014-2025
Zhengzhou University
2024
Zhejiang University
2018-2019
Committee on Publication Ethics
2018
Sir Run Run Shaw Hospital
2018
The increasing prevalence of antibacterial resistance globally underscores the urgent need to update antibiotics. Here, we describe a strategy for inducing self-assembly host-defense antimicrobial peptide (AMP) into nanoparticle antibiotics (termed nanobiotics) with significantly improved pharmacological properties. Our involves myristoylation human α-defensin 5 (HD5) as therapeutic target and subsequent in aqueous media absence exogenous excipients. Compared its parent HD5, C-terminally...
Abstract What We Already Know about This Topic Article Tells Us That Is New Background Pyroptosis, a type of proinflammatory programmed cell death, drives cytokine storm. Caspase-11–dependent macrophage pyroptosis contributes to mortality during sepsis. Sphingosine-1-phosphate receptor 2 (S1PR2) signaling can amplify interleukin-1β secretion in endotoxin-induced inflammation. Here, we hypothesized that S1PR2 increases caspase-11–dependent and worsens Gram-negative sepsis outcome. Methods A...
The objective of this paper is to investigate the clinical features, outcomes, and risk factors for posterior reversible encephalopathy syndrome (PRES) in systemic lupus erythematosus (SLE).From 2011 October 2017, SLE patients with PRES were identified from First Affiliated Hospital Zhengzhou University, China. Patients presenting neuropsychiatric hospitalized same period included as controls. Additionally, survival status was acquired via telephone follow-up March 2018.Thirty episodes 29 a...
Gram-negative sepsis has become a substantial and escalating global healthcare challenge due to the growing antibiotic resistance crisis sluggish development of new antibiotics. LL-37, unique Cathelicidin species found in humans, exhibits wide range bioactive properties, including direct bactericidal effects, inflammation regulation, LPS neutralization. KR-12, smallest yet potent peptide fragment been modified create more effective antimicrobials. In this study, we designed two myristoylated...
Although the prognosis of posterior reversible encephalopathy syndrome (PRES) is usually favourable and most patients wholly recover, disorder can result in death some patients. To date, data on clinical features risk factors for are still lacking; therefore, we aim to investigate long-term prognostic PRES present study.The with were identified from First Affiliated Hospital Zhengzhou University June 2011 2020. Clinical characteristics, laboratory tests, magnetic resonance imaging...
<title>Abstract</title> Purpose To explore the efficacy and safety of sivelestat (SV) in treatment severe acute pancreatitis (SAP) with systemic inflammatory response syndrome (SIRS). Methods A total 71 SAP patients diagnosed treated Emergency Intensive Care Unit First Affiliated Hospital Zhengzhou University from January 2021 to June 2023 were selected. The changes disease outcome, hospital stays mortality compared between two groups. Results recruited control group (n = 42) or SV 29)...
The present study aimed to identify the module genes and key gene functions biological pathways of septic shock (SS) through integrated bioinformatics analysis.In study, we performed batch correction principal component analysis on 282 SS samples 79 normal control in three datasets, GSE26440, GSE95233 GSE57065, obtain a combined corrected expression matrix containing 21,654 transcripts. Patients with were then divided into molecular subtypes according sample subtyping analysis.By analyzing...
Objective To investigate the gene mutations, clinical manifestations, imaging features, treatments and pathophysiologic mechanisms of patients with late-onset methylmalonic aciduria, cblC type. Methods Two boys one girl were diagnosed as combined aciduria homocystinuria type by MMCHC sequencing at their 13, 12 17 years old, respectively. Their laboratory findings responses treatment reviewed. Results The MMACHC mutations in case 1 c.482G>A c.609G>A. For 2, they c.658_660delAAG....
Abstract Gram-negative sepsis has become one of major increasing medical burdens globally, which is subjected to growing antibiotic resistance problem and the relatively delayed development new antibiotics. LL-37, only type Cathelicidin identified in humans, diverse biological activities including direct bactericidal action, regulation inflammation LPS-neutralization. The KR-12 peptide smallest portion LL-37 with antibacterial been shown that could be modified into more effective...
Abstract Background The ratio of hemoglobin to red blood cell distribution width (HRR) can reflect the degree oxidative stress and systemic inflammatory response in body, is a potential indicator predict prognosis patients with cardiac arrest (CA). Methods We retrospectively analyzed 126 successfully resuscitated after out-of-hospital arrest. Patients were grouped according their survival status at discharge: 35 survived 91 died. Binary logistic regression was used analyze independent...
Objective RY-15, a specific agonist of Sphingosine 1-phosphate Receptor 3, was synthesized for investigating the function and mechanism S1PR3 in bacterial clearance. Methods Measure ability RY-15 with FITC to enter THP-1 cell after coculture 5 min, 10 20 30 min through confocal microscopy. The GY-5 clearance observed by gentamicin protection test. phosphorylation level ERK p-ERK detected Western Blot stimulation different times. Results According microscopy, started stimulating...