A5101663142- Radiomics and Machine Learning in Medical Imaging
- Hepatocellular Carcinoma Treatment and Prognosis
- MRI in cancer diagnosis
- Advanced X-ray and CT Imaging
- Liver Disease Diagnosis and Treatment
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Colorectal Cancer Surgical Treatments
- Gastric Cancer Management and Outcomes
- Sepsis Diagnosis and Treatment
- Acute Kidney Injury Research
- Sarcoma Diagnosis and Treatment
- Lung Cancer Treatments and Mutations
- Colorectal and Anal Carcinomas
- Lung Cancer Diagnosis and Treatment
- Anesthesia and Neurotoxicity Research
- Cancer Immunotherapy and Biomarkers
- Renal cell carcinoma treatment
- Cardiac Imaging and Diagnostics
- Receptor Mechanisms and Signaling
- Cancer, Lipids, and Metabolism
- Bone Tumor Diagnosis and Treatments
- Endometrial and Cervical Cancer Treatments
- Neuroscience and Neuropharmacology Research
- Urinary and Genital Oncology Studies
- Redox biology and oxidative stress
Second Affiliated Hospital of Zhejiang University
2022-2025
Hong Kong University of Science and Technology
2025
University of Hong Kong
2025
Chinese Academy of Medical Sciences & Peking Union Medical College
2023-2024
Xiangya Hospital Central South University
2024
Central South University
2024
Zhejiang University
2021-2024
Wenzhou Medical University
2016-2024
Second Affiliated Hospital & Yuying Children's Hospital of Wenzhou Medical University
2018-2024
National Clinical Research
2023-2024
Sepsis is a leading cause of death in critical illness, and its pathophysiology varies depending on preexisting medical conditions. Here we identified nonalcoholic fatty liver disease (NAFLD) as an independent risk factor for sepsis large clinical cohort showed link between mortality NAFLD-associated hepatic mitochondrial energetic metabolism dysfunction. Using vivo vitro models lipid overload, discovered metabolic coordination hepatocyte mitochondria macrophages that express triggering...
Abstract Background Aging is a dynamic and heterogeneous process that may better be captured by trajectories of aging biomarkers. Biological age has been advocated as biomarker than chronological age, plant-based dietary patterns have found to linked aging. However, the associations biological with mortality remained unclear. Methods Using group-based trajectory modeling approach, we identified distinctive groups among 12,784 participants based on recently developed measure acquired at...
We aimed to identify imaging biomarkers assess predictive capacity of radiomics nomogram regarding treatment response status (responder/non-responder) in patients with advanced NSCLC undergoing anti-PD1 immunotherapy.197 eligible histologically confirmed were retrospectively enrolled from nine hospitals. carried out a characterization target lesions (TL) approach and largest lesion (LL) on baseline first follow-up (TP1) CT data. Delta-radiomics feature was calculated as the relative net...
Adipose tissue remodeling plays a significant role in obesity-induced insulin resistance. Published studies reported that level of trigger receptor expressed on myeloid cells 2 (TREM2) adipose is up-regulated animal models obesity. This study aims to investigate whether TREM2 regulates resistance via modulating mice high-fat diet (HFD).Wild-type (WT) and TREM2-/- were both fed with controlled-fat (CFD) or HFD for 12 weeks studied obesity Meanwhile, epididymal (EAT) was examined morphological...
The determination of risk factors for acute respiratory distress syndrome (ARDS) patients remains a challenge. Our study aims to explore the epidemiology and affecting outcomes ARDS provide theoretical basis patients' prognosis.This retrospective included 207 admitted general intensive care unit (ICU) in Second Affiliated Hospital Harbin Medical University from Jan 1st, 2016 2017. criteria were defined according Berlin Definition, clinical data collected medical record system. mortality rate...
Background Chondrosarcoma (CS) is the second most common primary malignant bone tumor, with a relatively high recurrence rate. However, an effective method that estimates whether pelvic CS will recur after surgery, which influences formulation of clinical treatment plan, remains lacking. Purpose To develop and validate radiomics nomograms based on 3D multiparametric magnetic resonance imaging (mpMRI) features characteristics could estimate early (ER) (≤1 year) CS. Study Type Retrospective....
To investigate the magnetic resonance imaging (MRI)-based radiomics value in predicting survival of patients with locally advanced cervical squamous cell cancer (LACSC) treated concurrent chemoradiotherapy (CCRT).A total 185 (training group: n = 128; testing 57) LACSC CCRT between January 2014 and December 2018 were retrospectively enrolled this study. A 400 features extracted from T2-weighted imaging, apparent diffusion coefficient map, arterial- delayed-phase contrast-enhanced MRI....
Background Histopathologic evaluation after surgery is the gold standard to evaluate treatment response neoadjuvant chemoradiotherapy (nCRT) in locally advanced rectal cancer (LARC). However, it cannot be used guide organ‐preserving strategies due poor timeliness. Purpose To develop and validate a multiscale model incorporating radiomics pathomics features for predicting pathological good (pGR) of down‐staging stage ypT0‐1N0 nCRT. Study Type Retrospective. Population A total 153 patients...
To predict the tertiary lymphoid structures (TLSs) status and recurrence-free survival (RFS) of intrahepatic cholangiocarcinoma (ICC) patients using preoperative CT radiomics.A total 116 ICC were included (training: 86; external validation: 30). The enhanced images performed for radiomics model. logistic regression analysis was applied clinical combined model based on models.A 107 features extracted, after being eliminated selected, six to establish a TLSs prediction. Arterial phase diffuse...
To explore and compare the performance of LI-RADS® radiomics from multiparametric MRI in predicting microvascular invasion (MVI) preoperatively patients with solitary hepatocellular carcinoma (HCC)< 5 cm.
Metabolic syndrome (MetS) encompasses a collection of metabolic abnormalities. This study aims to determine which combination MetS components has the highest mortality risk, and investigate causal relationships between longevity. Prospective analyses were conducted on 340,196 participants from MJ cohort at baseline, 121,936 had follow-up information. We defined according NCEP ATP III criteria. The study's outcomes included cardiovascular disease (CVD), cancer, all causes combined. employed...
Named entity recognition (NER) is the basic task of constructing a high-quality knowledge graph, which can provide reliable in auxiliary diagnosis dairy cow disease, thus alleviating problems missed and misdiagnosis due to lack professional veterinarians China. Targeting characteristics Chinese diseases corpus, we propose an ensemble NER model incorporating character-level, pinyin-level, glyph-level, lexical-level features characters. These multi-level were concatenated fed into...
Partial hepatectomy is the first option for intrahepatic mass-forming cholangiocarcinoma (IMCC) treatment, which would prolong survival. The main reason poor outcome after curative resection high incidence of early recurrence (ER). aim this study was to investigate combined predictive performance qualitative and quantitative magnetic resonance imaging (MRI) features prognostic immunohistochemical markers ER IMCC. Forty-seven patients with pathologically proven IMCC were enrolled in...
This study aims to explore the mechanism of immunosuppression in septic Acute Renal Injury (AKI) and role programmed death-1 (PD-1/PD-L1) pathway AKI. established a AKI model by Cecal ligation puncture (CLP) C57/B6 mice, ELISA was used test level lactate creatinine serum, blood collected for flow cytometry kidney samples Western blot analyses. further analyzed expression PD-L1 PD-1 CD4+, CD8+ T cell, number CD3+ cells identify apoptosis blood. The CLP sepsis induced mice; were increased...
Based on non-contrast-enhanced (NCE)/contrast-enhanced (CE) computed tomography (CT) images, we try to identify a combined-radiomics model and evaluate its predictive capacity regarding response anti-PD1 immunotherapy of patients with non-small-cell lung cancer (NSCLC).131 NSCLC undergoing were retrospectively enrolled from 7 institutions. Using largest lesion (LL) target lesions (TL) approaches, performed radiomics analysis based pretreatment NCE-CT (NCE-radiomics) CE-CT images...
Objective: To develop and validate clinical-radiomics nomograms based on three-dimensional CT multiparametric MRI (mpMRI) for pre-operative differentiation of sacral chordoma (SC) giant cell tumor (SGCT). Methods: A total 83 SC 54 SGCT patients diagnosed through surgical pathology were retrospectively analyzed. We built six models CT, enhancement (CTE), T 1 weighted, 2 diffusion-weighted imaging (DWI), contrast-enhanced weighted features, two radiomics combined mixed features with clinical...
Intracranial progression is considered an important cause of treatment failure in anaplastic lymphoma kinase (ALK)-positive non-small cell lung cancer (NSCLC) patients. Recent advances targeted therapy and radiomics have generated considerable interest for the exploration prognostic imaging biomarkers to predict clinical course. Here, we developed a magnetic resonance (MRI) radiomic signature that can stratify survival intracranial progression.We analyzed 87 brain metastatic lesions 24...
This study aims to assess the performance of radiomics approaches based on 3D computed tomography (CT), clinical and semantic features in predicting pathological classification thymic epithelial tumors (TETs).A total 190 patients who underwent surgical resection had pathologically confirmed TETs were enrolled this retrospective study. All non-contrast-enhanced CT (NECT) scans contrast-enhanced (CECT) before treatment. A 396 hand-crafted each patient extracted from volume interest NECT CECT...