A5086774933- RNA modifications and cancer
- MicroRNA in disease regulation
- Circular RNAs in diseases
- Cancer-related molecular mechanisms research
- Cancer-related gene regulation
- Bone Tissue Engineering Materials
- Renal cell carcinoma treatment
- Cancer, Hypoxia, and Metabolism
- Hip and Femur Fractures
- Adenosine and Purinergic Signaling
- Mechanisms of cancer metastasis
- Periodontal Regeneration and Treatments
- Ferroptosis and cancer prognosis
- Bone fractures and treatments
- Osteoarthritis Treatment and Mechanisms
- Obstructive Sleep Apnea Research
- Thermal Regulation in Medicine
- Cardiac tumors and thrombi
- HVDC Systems and Fault Protection
- Healthcare and Venom Research
- Complement system in diseases
- Single-cell and spatial transcriptomics
- Elbow and Forearm Trauma Treatment
- Allergic Rhinitis and Sensitization
- Herpesvirus Infections and Treatments
Sir Run Run Shaw Hospital
2020-2024
Zhejiang University
2020-2024
Shanghai Jiao Tong University
2006-2024
Shanghai Children's Medical Center
2006-2024
China Medical University
2013-2023
Okayama University
2022
First Affiliated Hospital Zhejiang University
2019
XinHua Hospital
2005-2006
Abstract Background Sunitinib resistance can be classified into primary and secondary resistance. While accumulating research has indicated several underlying factors contributing to sunitinib resistance, the precise mechanisms in renal cell carcinoma are still unclear. Methods RNA sequencing m6A were used screen for functional genes involved In vitro vivo experiments carried out patient samples clinical information obtained analysis. Results We identified a tumor necrosis factor...
Circular RNA (circRNA) is a novel class noncoding (ncRNA) that plays critical role in various cancers, including prostate cancer (PCa). However, the clinical significance, biological function, and molecular mechanisms of circRNAs remain to be elucidated.A circRNA array was performed identified differentially expressed circRNAs. circPDE5A as which downregulated samples. Functionally, vitro vivo assays were applied explore PCa metastasis. Mechanistically, interaction between WTAP verified...
Circular RNAs (circRNAs) have been reported to play a significant role in tumorigenesis. However, the detailed function of circRNA prostate cancer (PCa) is still largely unknown.We quantified circTFDP2 expression PCa tissues and adjacent normal using quantitative reverse transcription-polymerase chain reaction (qRT-PCR). Colony formation, Cell Counting Kit-8 (CCK-8), flow cytometry, transwell, vivo progression metastasis assays were applied reveal proliferation metastatic abilities cells....
Clear cell renal carcinoma (ccRCC) is the most lethal urological cancer and characterized by a high rate of metastasis relapse. N6-Methyladenosine (m6A) implicated in various stages development. However, thorough understanding m6A-modified lncRNAs ccRCC lacking. The results showed that METTL14 had decreased expression tissues. In addition, was negatively correlated to prognosis, stage, tumor grade. silencing shown significantly increase vitro vivo. High-throughput methylated RNA...
The effects of resveratrol on osteoarthritis (OA) pathogenesis have been demonstrated in vitro and animal models employing intra-articular injections. However, the potential for oral supplements to mediate protective OA not examined. Therefore, aim present study was investigate anti-OA mice fed a high-fat diet (HFD). C57BL/6J male were either standard or HFD, subset latter also received varying doses resveratrol. Twelve weeks later, all animals sacrificed knee joints evaluated with...
Adipose tissue remodeling plays a significant role in obesity-induced insulin resistance. Published studies reported that level of trigger receptor expressed on myeloid cells 2 (TREM2) adipose is up-regulated animal models obesity. This study aims to investigate whether TREM2 regulates resistance via modulating mice high-fat diet (HFD).Wild-type (WT) and TREM2-/- were both fed with controlled-fat (CFD) or HFD for 12 weeks studied obesity Meanwhile, epididymal (EAT) was examined morphological...
Bladder cancer is one of the most common and deadly worldwide.Current chemotherapy has shown limited efficacy in improving outcomes for patients.Nitroxoline, an old widely used oral antibiotic, which was known to treat urinary tract infection decades.Recent studies suggested that nitroxoline suppressed tumor progression metastasis, especially bladder cancer.However, underlying mechanism anti-tumor activity remains unclear.Methods: CircRNA microarray explore nitroxoline-mediated circRNA...
7-methylguanosine (m7G) modification is recently found to conservatively exist in RNA internal position besides mRNA caps and mediates the various metabolisms. As core confirmed transmethylase of m7G modification, METTL1 has been reported certain human cancers. However, role at miRNAs its writer bladder cancer (BCa) remains be elucidated. Here, we demonstrated that was indispensable for BCa proliferation metastasis vitro vivo. By combining miRNA sequencing, methylated immunoprecipitation...
The natural polyphenolic compound, resveratrol, has been shown to exhibit anti-osteoarthritic activity. Therefore it is hypothesized that resveratrol may serve as a nutritional supplement counteract osteoarthritis (OA). However, the mechanisms responsible for these effects have not yet fully elucidated. aim of this study was determine whether biological against interleukin (IL)-1β‑induced inflammation in human articular chondrocytes involved both Toll-like receptor 4 (TLR4)/myeloid...
Metabolism reprograming is a hallmark of cancer and plays an important role in tumor progression. The aberrant metabolism renal cell carcinoma (RCC) leads to accumulation the oncometabolite L-2-hydroxyglurate (L-2HG). L-2HG has been reported inhibit activity some α-ketoglutarate-dependent dioxygenases such as TET enzymes, which mediate epigenetic alteration, including DNA histone demethylation. However, detailed functions have not investigated thoroughly. In our study, we found that was...
Circular RNAs (circRNAs) have been recognized as important regulators in tumorigenesis. However, the specific role of circRNAs prostate cancer is still largely unknown. Here, we identified that circPHF16 was downregulated (PCa) tissues compared with normal tissues. Functionally, restrained metastasis both vivo and vitro. Mechanistically, directly interacted miR-581, leading to downregulation ring finger protein 128 (RNF128) inhibiting metastatic ability PCa. Furthermore, circPHF16-dependent...
Excessive visceral fat accumulation is associated with metabolic disorders. Di-(2-ethylhexyl) phthalate (DEHP), a candidate environmental obesogen, affects lipid metabolism and adipogenesis. Perinatal exposure to DEHP may be disorders of dams offspring. The aim the present study was explore effects pregnant on distribution their offspring, determine mechanisms for these effects. Pregnant C57BL/6J mice were administered via gavage (0.05 or 500 mg/kg/day) from gestational days 1‑19. Pups...
Clear-cell renal cell carcinoma is one of the most common tumors disagnosed, with nearly third patients diagnosed metastatic ccRCC. Although an increasing number studies has revealed that piwi-interacting RNAs are aberrantly expressed in diverse types cancers, few them explored detailed molecular mechanism piRNAs carcinogenesis, particularly In this study, differentially associated ccRCC were selected by using piRNA-sequencing combined TCGA data analysis, and piR-57125 was identified....
Renal cell carcinoma (RCC) is characterized by a high rate of distant metastasis, which leads to poor prognosis in patients with advanced RCC. PUS10 has been recognized as member the pseudouridine synthase family, and recently other functions beyond synthesis RNA modification have uncovered. However, little known about its role diseases such cancer. RT-qPCR, western blot immunohistochemistry were used measure expression RCC tissues. Transwell assay, wound healing vivo metastasis model...
The methyltransferase Wilms' tumor 1-associated protein (WTAP) has been reported to be dysregulated in various tumors. However, its role renal cell carcinoma (RCC) remains elusive. Here, we explored whether WTAP was upregulated RCC specimens compared normal tissues. Functionally, promoted proliferation and metastasis vivo vitro. Mechanistically, act as an N6-methyladenosine transferase regulate the m6A modification of long noncoding RNA TEX41. Then, destabilized TEX41 a YTHDF2-dependent...