A5044109027- Nanoplatforms for cancer theranostics
- Luminescence and Fluorescent Materials
- Circular RNAs in diseases
- MicroRNA in disease regulation
- RNA modifications and cancer
- Bladder and Urothelial Cancer Treatments
- Advanced Nanomaterials in Catalysis
- Photoacoustic and Ultrasonic Imaging
- Carbon and Quantum Dots Applications
- Urologic and reproductive health conditions
- Adenosine and Purinergic Signaling
- Renal cell carcinoma treatment
- Advanced biosensing and bioanalysis techniques
- Renal and related cancers
- Mechanisms of cancer metastasis
- Optical properties and cooling technologies in crystalline materials
- Ureteral procedures and complications
- Prostate Cancer Diagnosis and Treatment
- Melanoma and MAPK Pathways
- Inflammasome and immune disorders
- Nanocluster Synthesis and Applications
- Minimally Invasive Surgical Techniques
- Nuclear Receptors and Signaling
- Ferroptosis and cancer prognosis
- Pituitary Gland Disorders and Treatments
Sir Run Run Shaw Hospital
2017-2024
Zhejiang University
2017-2024
State Key Laboratory of Modern Optical Instruments
2022
Heilongjiang University
2021
Hangzhou Xixi hospital
2019
Theranostic systems combining fluorescence imaging in the second near-infrared window (NIR-II, 1000-1700 nm) and photothermal therapy (PTT) under safe laser fluence have great potential preclinical research clinical practice, but development of such with sufficient effective NIR-II brightness excellent properties is still challenging. Here we report a theranostic system based on semiconducting polymer nanoparticles (L1057 NPs) for PTT 980 nm irradiation, low (25 mW/cm2) high (720 fluence,...
Second near-infrared (NIR-II, 1000-1700 nm) fluorescence bioimaging has attracted tremendous scientific interest and already been used in many biomedical studies. However, reports on organic NIR-II fluorescent probes for vivo photoinduced imaging simultaneous therapy, as well the long-term tracing of specific biological objects, are still very rare. Herein we designed a single-molecular NIR-II-emissive theranostic system by encapsulating kind aggregation-induced emission luminogen (AIEgen,...
Abstract Fluorescence bioimaging in the second near‐infrared spectral region (NIR‐II, 1000–1700 nm) can provide advantages of high spatial resolution and large penetration depth, due to low light scattering. However, NIR‐II fluorophores simultaneously possessing brightness, good stability, biocompatibility are very rare. Hydrophobic emissive PbS@CdS quantum dots (QDs) surface‐functionalized, via a silica amphiphilic polymer (Pluronic F‐127) dual‐layer coating method. The as‐synthesized...
Abstract Background Sunitinib resistance can be classified into primary and secondary resistance. While accumulating research has indicated several underlying factors contributing to sunitinib resistance, the precise mechanisms in renal cell carcinoma are still unclear. Methods RNA sequencing m6A were used screen for functional genes involved In vitro vivo experiments carried out patient samples clinical information obtained analysis. Results We identified a tumor necrosis factor...
Circular RNA (circRNA) is a type of circular endogenous produced by special selective splicing and participates in progression diverse diseases. However, the role circRNA clear cell renal carcinoma (ccRCC) still rarely reported.We detected lower circ-AKT3 expression ccRCC using microarray. Then, qPCR array was applied to verify between 60 tissues adjacent normal tissues, as well lines human kidney (HK-2). We investigated function vitro vivo underlying mechanisms Western blotting,...
Abstract Superb reliability and biocompatibility equip aggregation‐induced emission (AIE) dots with tremendous potential for fluorescence bioimaging. However, there is still a chronic lack of design instructions excretable bright AIE emitters. Here, kind PEGylated (OTPA‐BBT) strong absorption extremely high second near‐infrared region (NIR‐II) PLQY 13.6% designed, long‐aliphatic‐chain blueprint contributing to their excretion from an animal's body proposed. Assisted by the OTPA‐BBT beyond...
Circular RNA (circRNA) is a novel class noncoding (ncRNA) that plays critical role in various cancers, including prostate cancer (PCa). However, the clinical significance, biological function, and molecular mechanisms of circRNAs remain to be elucidated.A circRNA array was performed identified differentially expressed circRNAs. circPDE5A as which downregulated samples. Functionally, vitro vivo assays were applied explore PCa metastasis. Mechanistically, interaction between WTAP verified...
Circular RNAs (circRNAs) have been reported to play a significant role in tumorigenesis. However, the detailed function of circRNA prostate cancer (PCa) is still largely unknown.We quantified circTFDP2 expression PCa tissues and adjacent normal using quantitative reverse transcription-polymerase chain reaction (qRT-PCR). Colony formation, Cell Counting Kit-8 (CCK-8), flow cytometry, transwell, vivo progression metastasis assays were applied reveal proliferation metastatic abilities cells....
Benefiting from excellent spatial resolution and penetration depth, ICG-assisted NIR-II (900–1700 nm) fluorescence microscopy is promising for clinical applications, especially in accurate theranostics of cerebrovascular diseases malignancies.
: Biliary tract injury remains the most dreaded complication during laparoscopic cholecystectomy. New intraoperative guidance technologies, including near-infrared (NIR) fluorescence cholangiography with indocyanine green (ICG), are under comprehensive evaluation. Previous studies had shown limitations of traditional NIR light (NIR-I, 700-900 nm) in visualizing biliary structures specific clinical situations. The aim this study was to evaluate feasibility performing extrahepatic second...
Theranostic agents with fluorescence in the second near-infrared (NIR-II) window, especially its long-wavelength region, and NIR-II-excitable photothermal effect is promising but challenging tumor diagnosis therapy. Here, we report a simple effective strategy to develop semiconducting polymer nanoparticles-based theranostic (PBQx NPs) demonstrate their applications for NIR-II imaging beyond 1400 nm therapy (PTT) of tumors upon excitation at 1064 nm. Both experimental results theory...
Bladder cancer is one of the most common and deadly worldwide.Current chemotherapy has shown limited efficacy in improving outcomes for patients.Nitroxoline, an old widely used oral antibiotic, which was known to treat urinary tract infection decades.Recent studies suggested that nitroxoline suppressed tumor progression metastasis, especially bladder cancer.However, underlying mechanism anti-tumor activity remains unclear.Methods: CircRNA microarray explore nitroxoline-mediated circRNA...
To evaluate the early functional and oncological outcomes of single-port robot-assisted perineal radical prostatectomy (sp-pRARP) using da Vinci XI system analyze its learning curve cumulative sum (CUSUM) method.The clinical data 50 patients who underwent sp-pRARP for localized prostate cancer between May 2020 2022 in our center by a single surgeon were analyzed retrospectively. Demographic information, preoperative postoperative variables, complications, recorded. The CUSUM method was used...
Abstract Bright anti-Stokes fluorescence (ASF) in the first near-infrared spectral region (NIR-I, 800 nm–900 nm) under excitation of a 915 nm continuous wave (CW) laser, is observed Indocyanine Green (ICG), dye approved by Food and Drug Administration for clinical use. The dependence intensity on light power temperature, together with lifetime measurement, establish this ASF to be originated from absorption thermally excited vibrational level (hot-band absorption), as shown our experiments,...
Metabolism reprograming is a hallmark of cancer and plays an important role in tumor progression. The aberrant metabolism renal cell carcinoma (RCC) leads to accumulation the oncometabolite L-2-hydroxyglurate (L-2HG). L-2HG has been reported inhibit activity some α-ketoglutarate-dependent dioxygenases such as TET enzymes, which mediate epigenetic alteration, including DNA histone demethylation. However, detailed functions have not investigated thoroughly. In our study, we found that was...
Accurate structural and functional imaging is vital for the diagnosis prognosis of urinary system diseases. Fluorescence bioimaging in second near-infrared spectral region (NIR-II, 1000–1700 nm) has shown advantages higher spatial resolution, deeper penetration, finer signal-to-background ratio (SBR) compared to conventional fluorescence methods but limited its clinical inapplicability. Herein, we first report vivo NIR-II enabled by a clinically approved renal excretable dye methylene blue...
Seminoma is the most common testicular germ cell tumor worldwide and mainly occurs in 15‐35‐year‐old young men. Early studies have indicated that nuclear receptor 4 ( TR 4) first cloned from testis involved invasion metastasis of several human tumors; however, little attention paid to function seminoma. Our immunohistochemical IHC ) staining results showed patients with advanced stage tumors tended higher expression 4. Importantly, there was a significant association between elevated reduced...
Purpose Clear cell renal carcinoma(ccRCC) is the most common type of carcinoma. While it curable when detected at an early stage, some patients presented with advanced disease have poor prognosis. We aimed to identify key genes and miRNAs associated clinical prognosis in ccRCC. Methods The microarray datasets were obtained from Gene Expression Omnibus database. Differentially expressed (DEGs) differentially (DEMs) analyzed by using GEO2R. Then, Functional enrichment analysis was performed...
Single-port robotic-assisted radical laparoscopic prostatectomy has emerged as a novel in recent years, arousing wide attention. However, single-port using Si da Vinci surgical system been rarely reported, especially via the transperineal approach.We retrospectively collected 9 cases of prostate cancer patients who underwent robot-assisted (t-spPARP) our center from May 2020 to June 2020. The operation time, estimated blood loss (EBL), complications, changes prostate-specific antigen (PSA) 3...
Abstract Nowadays, gene expression profiling has been widely used in screening out prognostic biomarkers numerous kinds of carcinoma. Our studies attempt to construct a clinical nomogram which combines risk signature and features for individual recurrent assessment offer personalized managements clear cell renal A total 580 differentially expressed genes (DEGs) were identified via microarray. Functional analysis revealed that DEGs are fundamental importance ccRCC progression metastasis. In...
Abstract Drug options for the life‐threatening Cushing's disease are limited, and surgical resection or radiation therapy is not invariably effective. Testicular receptor 4 (TR4) has been identified as a novel drug target to treat disease. We built structure model of TR4 searched antagonist candidate via in silico virtual screening. Bexarotene was an that can directly interact with ligand binding domain (TR4‐LBD) induces conformational change secondary TR4‐LBD. suppressed AtT‐20 cell growth,...
Testicular nuclear receptor 4 (TR4) is a member of the hormone family and acts as ligand-activated transcription factor functions in many biological processes, such development, cellular differentiation, homeostasis. Recent studies have shown that TR4 plays an important role prostate cancer, renal cell carcinoma, hepatocellular carcinoma; however, its potential link to bladder cancer (BC) remains unknown. This study found exhibited higher expression compared normal tissues. Overexpressed...
Abstract Background Urosepsis is a life-threatening organ disease in which pathogenic microorganisms the urine enter blood through vessels, causing an imbalance immune response to infection. The aim of this study was elucidate role testicular orphan receptor 4 (TR4) urosepsis. Methods TR4 progression and prognosis urosepsis confirmed by analyzing data from online databases clinical human samples. To mimic urosepsis, we injected E. coli bacteria into renal pelvis mice create model....