A5046527141- Cancer-related molecular mechanisms research
- MicroRNA in disease regulation
- Microbial bioremediation and biosurfactants
- Memory and Neural Mechanisms
- Photoreceptor and optogenetics research
- Toxic Organic Pollutants Impact
- Neuroscience and Neural Engineering
- Bone Tissue Engineering Materials
- Radiomics and Machine Learning in Medical Imaging
- Knee injuries and reconstruction techniques
- Osteoarthritis Treatment and Mechanisms
- RNA modifications and cancer
- Circular RNAs in diseases
- Epigenetics and DNA Methylation
- Photochromic and Fluorescence Chemistry
- Microplastics and Plastic Pollution
- Neuroendocrine regulation and behavior
- Cancer Immunotherapy and Biomarkers
- Pluripotent Stem Cells Research
- Tissue Engineering and Regenerative Medicine
- Zebrafish Biomedical Research Applications
- Environmental remediation with nanomaterials
- Tendon Structure and Treatment
- Cancer Research and Treatments
- Vascular Malformations and Hemangiomas
Chinese University of Hong Kong
2021-2025
Prince of Wales Hospital
2023-2025
Shihezi University
2025
Shenzhen University
2023-2024
Huazhong University of Science and Technology
2018-2024
Wuxi No.2 People's Hospital
2024
Nankai University
2007-2024
Kanion Pharmaceutical (China)
2024
Nantong University
2024
Union Hospital
2022-2024
Despite intensive effort was made to regenerate injured meniscus by cell-free strategies through recruiting endogenous stem/progenitor cells, regeneration remains a great challenge in clinic. In this study, we found decellularized meniscal extracellular matrix (MECM) preserved native collagen and glycosaminoglycans which could be good guider for stem cells. Moreover, MECM significantly promoted fibrochondrocytes viability proliferation, increased the expression of type II proteoglycans...
Elevated bone resorption and diminished formation have been recognized as the primary features of glucocorticoid-associated skeletal disorders. However, direct effects excess glucocorticoids on turnover remains unclear. Here, we explored outcomes exogenous glucocorticoid treatment loss delayed fracture healing in mice found that reduced was a dominant feature, resulting net mass. The effect osteogenic differentiation not inhibitory; instead, they cooperated with macrophages to facilitate...
Abstract Currently, surfactants are widely distributed in the environment. As organic pollutants, their toxicities have drawn extensive attention. In this study, effects of anionic [sodium dodecyl sulphate (SDS) ], cationic [dodecyl dimethyl benzyl ammonium chloride (1227)] and non-ionic [fatty alcohol polyoxyethylene ether (AEO) ] on zebrafish larval behaviour were evaluated. Five behavioural parameters recorded using a rest/wake assay, including rest total, number bouts, bouts length,...
Background: Many microRNAs (miRs) are dysregulated in cancers, and aberrant miR expression patterns have been suggested to correlate with chemo-resistance of cancer cells. We aim study the role miR-30 family members cisplatin-resistance ovarian Methods: qRT-PCR was used compare differential levels cell line A2780 its cisplatin-resistant derivative CP70. Changes cisplatin-sensitivity miR-30a-5p- miR-30c-5p-overexpressed-CP70 cells miR-30c-5p-inhibited-A2780 were examined by CCK8 assay...
Heterogeneity of mesenchymal stem cells (MSCs) influences the cell therapy outcome and application in tissue engineering.Also, subpopulations MSCs cartilage regeneration remains poorly characterized.CD146+ are identified as natural ancestors expression CD146 indicative greater pluripotency self-renewal potential.Here, we sorted a + subpopulation from adipose-derived (ADSCs) for regeneration.Methods: ADSCs were using magnetic activated sorting (MACS).Cell surface markers, viability, apoptosis...
Recognition memory provides the ability to distinguish familiar from novel objects and places, is important for recording updating events guide appropriate behavior. The hippocampus (HPC) medial prefrontal cortex (mPFC) have both been implicated in recognition memory, but nature of HPC-mPFC interactions, its impact on local circuits mediating this process not known. Here we show that novelty discrimination accompanied with higher theta activity (4-10 Hz) increased c-Fos expression these...
Bone grafting is frequently conducted to treat bone defects caused by trauma and tumor removal, yet with significant medical socioeconomic burdens. Space-occupying substitutes remain challenging in the control of osteointegration, meanwhile activation endogenous periosteal cells using non-space-occupying implants promote new formation becomes another therapeutic strategy. Here, we fabricated a magnesium-based artificial bandage optimal micropatterns for activating periosteum-associated...
Novel biomarkers for pancreatic adenocarcinoma are urgently needed because of its poor prognosis. Here, by using The Cancer Genome Atlas (TCGA) RNA-seq data, we evaluated the prognostic values differentially expressed miRNAs and constructed a five-miRNA signature that could effectively predict patient overall survival (OS). Kaplan-Meier curves two groups based on five were notably different, showing in 10.2% 47.8% at years patients high-risk low-risk groups, respectively. ROC curve analysis...
Soil contamination with multiple heavy metals is a global environmental issue that poses serious threat to public health and ecological safety. Biochar passivation an efficient economical technology prevent metal of Cd; however, its effects on compound-contaminated weakly alkaline soil remain unclear. Further, the mechanisms mediating immobilization biochar have not been evaluated. In this study, three treated at different pyrolytic temperatures [300°C (BC300), 400°C (BC400), 500°C (BC500)]...
Chlorogenic acid (CGA) has strong antioxidant properties. In order to improve the low maturation rate and poor vitrification freezing effect of sheep oocytes caused by oxidative stress. this study, from 200 2-3-year-old Kazakh were collected, different concentrations CGA added medium solution study effects on rate, cleavage blastocyst reactive oxygen species (ROS) glutathione (GSH) levels, mitochondrial membrane potential, expression levels oxidation apoptosis-related genes in oocytes. The...
Rapid uterus involution is essential for minimising interpartum intervals, enhancing reproductive performance, and optimising production in ewes. This study aimed to accelerate the uterine of postpartum ewes through a relatively simple hormone treatment approach. In this study, 96 Dorper × Hu F1 were assigned three groups. The subsequently injected with normal saline (control group), prostaglandin + oxytocin (PG OT group) horse chorionic gonadotropin eCG group). Each group had 16 producing...
// Xiuhui Shi 1 , Yan Zhao Ruizhi He Min Zhou Shutao Pan Shuo Yu Xie Xu Li Wang Xingjun Guo and Renyi Qin Department of Biliary-Pancreatic Surgery, Affiliated Tongji Hospital, Medical College, Huazhong University Science Technology, Wuhan, China Correspondence to: Qin, email: ryqin@tjh.tjmu.edu.cn Guo, xjguo@tjh.tjmu.edu.cn Keywords: long noncoding RNA; pancreatic adenocarcinoma; TCGA; ceRNA; prognosis Received: August 23, 2017 Accepted: February 01,...
Synchronized activity in neural circuits, detected as oscillations the extracellular field potential, has been associated with learning and memory. Neural circuits basolateral amygdala (BLA), a mid-temporal lobe structure, generate specific frequency bands to mediate emotional memory functions. However, how BLA distinct is not known. Of these, sharp-waves (SWs) are repetitive, brief transitions that contain low-frequency (<20 Hz) envelope, often coupled ripples (100-300 Hz), have...
Abstract Bioceramics provide promising tactics for wound healing, yet the on‐shelf products are still unmet, especially skin appendages regeneration. Herein, inorganic magnesium silicate sprays (MSS) as mineral factors to overcome existing challenges is proposed. Results indicate MSS can be synthesized by a green method without organic solvents, templates, calcination, and harmful by‐products. With amorphous phase, nanoscale, high specific surface area, reveal an improved pH‐responsive...