A5050769901- Mesenchymal stem cell research
- Osteoarthritis Treatment and Mechanisms
- Wound Healing and Treatments
- Periodontal Regeneration and Treatments
- Graphene and Nanomaterials Applications
- Tissue Engineering and Regenerative Medicine
- Bone Tissue Engineering Materials
- Diabetic Foot Ulcer Assessment and Management
- Electrospun Nanofibers in Biomedical Applications
- Nanoplatforms for cancer theranostics
- Knee injuries and reconstruction techniques
- Bone Metabolism and Diseases
- Burn Injury Management and Outcomes
- Immune cells in cancer
- Bone health and treatments
- 3D Printing in Biomedical Research
- Advanced Glycation End Products research
- Bone health and osteoporosis research
- Bone fractures and treatments
- Silk-based biomaterials and applications
- RNA Interference and Gene Delivery
- Immune responses and vaccinations
- Phagocytosis and Immune Regulation
- Circadian rhythm and melatonin
- Alkaline Phosphatase Research Studies
Huazhong University of Science and Technology
2022-2025
Hubei Zhongshan Hospital
2022-2025
Wuhan University
2022-2025
Union Hospital
2022-2025
Wuhan Union Hospital
2024
Union Hospital
2023
Huazhong University of Science and Technology Hospital
2023
Chinese PLA General Hospital
2020-2022
PLA Academy of Military Science
2021
Nankai University
2019-2021
Diabetic wound (DW) therapy is currently a big challenge in medicine and strategies to enhance neurogenesis angiogenesis have appeared be promising direction. However, the current treatments failed coordinate simultaneously, leading an increased disability rate caused by DWs. Herein, whole-course-repair system introduced hydrogel concurrently achieve mutually supportive cycle of neurogenesis-angiogenesis under favorable immune-microenvironment. This can first one-step packaged syringe for...
The regeneration and repair of articular cartilage remains a major challenge for clinicians scientists due to the poor intrinsic healing this tissue. Since injuries are often clinically irregular, tissue-engineered scaffolds that can be easily molded fill defects any shape fit tightly into host needed.In study, bone marrow mesenchymal stem cell (BMSC) affinity peptide sequence PFSSTKT (PFS)-modified chondrocyte extracellular matrix (ECM) particles combined with GelMA hydrogel were...
Abstract Diabetic foot ulcer (DFU) is one of the most common complications diabetes, bringing physical and mental challenges for patients due to lack efficient curative therapy. Despite considerable advances in pharmacological surgical approaches, clinical trials DFU remain disappointing local overactive excessive inflammation. Immunomodulatory hydrogels has significant advantages overcome challenge DFUs Here, recent fabrication regenerative utilization functional altering immune...
The clinical applications of currently used photosensitizers are limited by high costs, inconvenient preparation, suboptimal biodegradability, and a lack biological activity. Humic acids (HAs) show photothermal activity can be as photosensitizer for therapy. In the presence various functional groups, HAs endowed with anti-inflammatory antioxidant activities. solubility is dependent on pH value, which soluble in neutral to alkaline conditions undergoes conformational change coiled compact...
Cartilage regeneration is a complex physiological process. Synovial macrophages play critical immunomodulatory role in the acute inflammatory response surrounding joint injury. Due to contrasting differences and heterogeneity of macrophage, phenotype are key determinants healing after cartilage Biomaterials derived from extracellular matrix have been used for repair reconstruction variety tissues by modulating host macrophage response. However, effect decellularized (ECM) on has not...
Articular cartilage (AC) lesions are fairly common but remain an obstacle for clinicians and researchers due to their poor self-healing capacity. Recently, a promising therapy based on the recruitment of autologous mesenchymal stem cells (MSCs) has been developed regeneration full-thickness defects in knee joint. In this study, 3D-bioprinted difunctional scaffold was aptamer HM69-mediated MSC-specific growth factor-enhanced cell chondrogenesis. The aptamer, which can specifically recognize...
MicroRNAs (miRNAs) broadly regulate normal biological functions of bone and the progression fracture healing osteoporosis. Recently, it has been reported that miR-1224-5p in plasma is a potential therapy for osteogenesis. To investigate roles Rap1 signaling pathway osteoporosis development progression, we used BMMs, BMSCs, skull osteoblast precursor cells vitro osteogenesis osteoclastogenesis studies. Osteoblastogenesis were detected by ALP, ARS, TRAP staining slice resorption pit assays....
Abstract The drug‐resistant bacterial‐infected skin wound is still a severe healthcare problem. Uncontrolled bacterial infection, abundant reactive oxygen species (ROS) content, and prolonged inflammatory response are detrimental to healing. Moreover, excessive vessel growth can result in unsatisfactory scar formation. Herein, three‐step regenerative strategy based on bilayered gelatin/acryloyl β ‐cyclodextrin (BGACD) hydrogel containing physical host–guest complexations chemical crosslinks...
It is imperative to develop and implement newer, more effective strategies address refractory diabetic wounds. As of now, there currently no optimal solution for these Hypoxic human umbilical vein endothelial cells (HUVECs)-derived exosomes have been postulated promote wound healing, however, its effect molecular mechanism need further study. In this study, we aimed investigate whether hypoxic enhance healing in diabetics. Based on our high-throughput sequencing, differentially expressed...
The diabetic wounds remain to be unsettled clinically, with chronic characterized by drug-resistant bacterial infections, compromised angiogenesis and oxidative damage the microenvironment. To ameliorate stress applying antioxidant treatment in wound site, we explore function of folliculin-interacting protein 1 (FNIP1), a mitochondrial gatekeeper works alter morphology, reduce phosphorylation protect cells from unwarranted ROS accumulation. And our vitro experiments showed effects FNIP1...
The diabetic wounds remain to be unsettled clinically, with chronic characterized by drug-resistant bacterial infections, compromised angiogenesis and oxidative damage the microenvironment. Hence, a novel designed glucose-responsive HA-PBA-FA/EN106 hydrogel is introduced for improving wound healing. Due dynamic phenylboronate ester structure phenylboronic acid group between hyaluronic (HA) (PBA), able realize release of drugs. Fulvic (FA) added in hydrogel, which not only severs as...
Bone nonunion poses an urgent clinical challenge that needs to be addressed. Recent studies have revealed the metabolic microenvironment plays a vital role in fracture healing. Macrophages and bone marrow-derived mesenchymal stromal cells (BMSCs) are important targets for therapeutic interventions fractures. Itaconate is TCA cycle metabolite has emerged as potent macrophage immunomodulator limits inflammatory response. During osteogenic differentiation, BMSCs tend undergo aerobic glycolysis...
Heterogeneity of mesenchymal stem cells (MSCs) influences the cell therapy outcome and application in tissue engineering.Also, subpopulations MSCs cartilage regeneration remains poorly characterized.CD146+ are identified as natural ancestors expression CD146 indicative greater pluripotency self-renewal potential.Here, we sorted a + subpopulation from adipose-derived (ADSCs) for regeneration.Methods: ADSCs were using magnetic activated sorting (MACS).Cell surface markers, viability, apoptosis...
Tissue engineering provides a promising avenue for treating cartilage defects. However, great challenges remain in the development of structurally and functionally optimized scaffolds repair regeneration. In this study, decellularized extracellular matrix (ECM) waterborne polyurethane (WPU) were employed to construct WPU WPU-ECM by water-based 3D printing using low-temperature deposition manufacturing (LDM) system, which combines rapid with phase separation techniques. The successfully...
Abstract Infected fracture healing is a complicated process that includes intricate interactions at the cellular and molecular levels. In addition to angiogenesis osteogenesis, significance of neurogenesis in has also been recognized recent years. Here, nanocomposite hydrogel containing pH‐responsive zinc‐gallium‐humic acids (HAs) nanoparticles developed. Through timed release Zn 2+ , Ga 3+ HAs, exhibits potent antibacterial effects promotes angiogenesis, neurogenesis. The enhanced further...