A5018853418- Tissue Engineering and Regenerative Medicine
- Electrospun Nanofibers in Biomedical Applications
- Bone Tissue Engineering Materials
- Cardiomyopathy and Myosin Studies
- Knee injuries and reconstruction techniques
- Peripheral Nerve Disorders
- Circadian rhythm and melatonin
- Nerve Injury and Rehabilitation
- Mesenchymal stem cell research
- Tendon Structure and Treatment
- Orthopaedic implants and arthroplasty
- Osteoarthritis Treatment and Mechanisms
- Cardiac electrophysiology and arrhythmias
- Cardiovascular Function and Risk Factors
- Dental Implant Techniques and Outcomes
- Total Knee Arthroplasty Outcomes
- Structural Load-Bearing Analysis
- Shoulder Injury and Treatment
- Periodontal Regeneration and Treatments
- Congenital heart defects research
- Cardiac Structural Anomalies and Repair
- Advancements in Semiconductor Devices and Circuit Design
- Advanced Computational Techniques and Applications
- Structural Behavior of Reinforced Concrete
- Industrial Technology and Control Systems
Affiliated Hospital of Southwest Medical University
2018-2025
Nanjing Medical University
2024
Jiangsu Province Hospital
2024
Huazhong University of Science and Technology
2023
Yale University
2019-2023
Fuzhou University
2023
The University of Sydney
2022
Southwest Medical University
2021
Chinese PLA General Hospital
2018-2021
Regenerative Medicine Institute
2018
Regeneration of an injured meniscus continues to be a scientific challenge due its poor self-healing potential. Tissue engineering provides avenue for regenerating severely damaged meniscus. In this study, we first investigated the superiority five concentrations (0%, 0.5%, 1%, 2%, and 4%) extracellular matrix (MECM)-based hydrogel in promoting cell proliferation matrix-forming phenotype meniscal fibrochondrocytes (MFCs). We found that 2% group strongly enhanced chondrogenic marker mRNA...
Heterogeneity of mesenchymal stem cells (MSCs) influences the cell therapy outcome and application in tissue engineering.Also, subpopulations MSCs cartilage regeneration remains poorly characterized.CD146+ are identified as natural ancestors expression CD146 indicative greater pluripotency self-renewal potential.Here, we sorted a + subpopulation from adipose-derived (ADSCs) for regeneration.Methods: ADSCs were using magnetic activated sorting (MACS).Cell surface markers, viability, apoptosis...
Human-induced pluripotent stem cell-derived cardiomyocytes (hiPSC-CMs) have wide potential application in basic research, drug discovery, and regenerative medicine, but functional maturation remains challenging. Here, we present a method whereby of hiPSC-CMs can be accelerated by simultaneous physiological Ca2+ frequency-ramped electrical pacing culture. This combination produces positive force-frequency behavior, twitch kinetics, robust β-adrenergic response, improved handling, cardiac...
Bioabsorbable magnesium alloys are becoming prominent materials for cardiovascular stents, as their desirable mechanical properties and favorable biosafety. However, the rapid corrosion of under physiological conditions hinders wider application medical implant materials. Fluoride chemical conversion treatment is an effective simple technique to improve resistance alloys. Despite previous literature reporting on fluoride with hydrofluoric acid (HF) in different conditions, some defects still...
We applied innovative methods to comprehensively characterize the length and load-dependent behaviors of engineered human cardiac muscle when treated with β-myosin specific inhibitor mavacamten, a drug on verge clinical implementation for hypertrophic cardiomyopathy. find mechanistic support role mavacamten in improving diastolic function tissue note novel effects work power.
This study aims to characterize a three-dimensional-printed hydroxyapatite (HA)/polycaprolactone (PCL) scaffold and assess its biocompatibility both in vitro vivo. A bionic, porous HA/PCL was fabricated using 3D printing, microstructure, porosity, hydrophilicity, mechanical properties were evaluated through scanning electron microscopy various assays. Bone marrow mesenchymal stem cells (BMSCs) vascular endothelial progenitor (VEPCs) co-cultured with the scaffold, their proliferation...
Abstract Background The repair of large bone defects is a great challenge for orthopedics. Although the development three-dimensional (3D) printed titanium alloy (Ti6Al4V) implants with optimized pore structure have effectively promoted osseointegration. However, due to biological inertia Ti6Al4Vsurface and neglect angiogenesis, some patients still suffer from postoperative complications such as dislocation or loosening prosthesis. Methods purpose this study was construct 3D porous Ti6Al4V...
Altered kinase localization is gaining appreciation as a mechanism of cardiovascular disease. Previous work suggests GSK-3β (glycogen synthase 3β) localizes to and regulates contractile function the myofilament. We aimed discover GSK-3β's in vivo role regulating myofilament function, mechanisms involved, translational relevance.
The performance capabilities of InP-based pnp heterojunction bipolar transistors (HBT's) have been investigated using a drift-diffusion transport model based on commercial numerical simulator. low hole mobility in the base is found to limit current gain and transit time, which limits device's cutoff frequency. high electron majority carrier n/sup +/ InGaAs allows reduction doping width while maintaining an adequately resistance. As result, (>300) power (>40 dB) are be possible at microwave...
The matrix metalloproteinases (MMPs) have come to be highlighted by their close relation the cell invasion of gliomas. inhibitors MMPs undergone extensive development because its effectiveness against tumor and angiogenesis. Therefore, a suitable animal model is necessary for searching new In this study, we established an experimental implanting 9L glioma cells stereotactically into Fisher344 (F344) rat's brain, expression enzymatic activity MMP‐2 MMP‐9 in tissue was determined means reverse...
BACKGROUND Intraoperative persistent hypotension (IPH) during pancreaticoduodenectomy (PD) is linked to adverse postoperative outcomes, yet its risk factors remain unclear. AIM To clarify the associated with IPH PD, ensuring patient safety in perioperative period. METHODS A retrospective analysis of records from January 2018 December 2022 at First Affiliated Hospital Nanjing Medical University identified PD. These included age, gender, body mass index, American Society Anesthesiologists...
Hypoxia is a common characteristic of solid tumors. Previous studies have reported that the tumor invasion-associated factor, AMPK-related protein kinase 5 (ARK5), associated with poor prognosis in colon cancer. However, whether or not ARK5 involved hypoxia unclear. The aim present study was to investigate association between expression and hypoxia-inducible factor 1-α (HIF1-α). Samples from 60 patients cancer were collected immunohistochemistry used detect HIF1-α within them. Western blot...
The existing connection between the concrete-filled double steel tubular (CFDST) column and reinforced concrete (RC) beam is difficult to repair reuse after damage. In this paper, a self-centering joint CFDST RC proposed. of realized by prestressed strands, energy dissipation friction. overall purpose research analyze influence strand friction on mechanical behavior joint. By comparing envelope curve restoring force model numerical with theoretical values, accuracy was verified. Then, joints...
We establish an optimal transportation inequality for the Poisson measure on configuration space. Furthermore, under Dobrushin uniqueness condition, we obtain a sharp Gibbs $ℕ^Λ$ or continuum
To manufacture a poly (lactic-co-glycolic acid) (PLGA) scaffold by low temperature deposition three-dimensional (3D) printing technology, prepare PLGA/decellularized articular cartilage extracellular matrix (DACECM) tissue engineered combining DACECM, and further investigate its physicochemical properties.PLGA scaffolds were prepared 3D DACECM suspensions was modified physical chemical decellularization methods. oriented using freeze-drying cross-linking techniques. PLGA/DACECM slurry with...