A5042912398- Erythrocyte Function and Pathophysiology
- Acute Myeloid Leukemia Research
- Hemoglobinopathies and Related Disorders
- Myeloproliferative Neoplasms: Diagnosis and Treatment
- Epigenetics and DNA Methylation
- Reconstructive Surgery and Microvascular Techniques
- Wound Healing and Treatments
- Dermatologic Treatments and Research
- MicroRNA in disease regulation
- Pancreatic function and diabetes
- RNA modifications and cancer
- Hippo pathway signaling and YAP/TAZ
- Nuclear Structure and Function
- RNA Research and Splicing
- RNA Interference and Gene Delivery
- Ubiquitin and proteasome pathways
- Cancer-related Molecular Pathways
- Blood properties and coagulation
- Histone Deacetylase Inhibitors Research
- Eosinophilic Disorders and Syndromes
- Chronic Myeloid Leukemia Treatments
- Hematopoietic Stem Cell Transplantation
- Genomics and Chromatin Dynamics
- Immune cells in cancer
- Connective Tissue Growth Factor Research
Hunan University
2025
China University of Petroleum, East China
2024
Robert H. Lurie Comprehensive Cancer Center of Northwestern University
2020-2024
Northwestern University
2015-2024
Air Force Medical University
2007-2024
Xijing Hospital
2007-2024
Shandong Shierming Eye Hospital
2024
Indo-American Center
2024
Gansu Agricultural University
2024
China National Offshore Oil Corporation (China)
2024
Many human aneuploidy syndromes have unique phenotypic consequences, but in most instances it is unclear whether these phenotypes are attributable to alterations the dosage of specific genes. In trisomy 13, there delayed switching and persistence fetal hemoglobin (HbF) elevation embryonic newborns. Using partial cases, we mapped this trait chromosomal band 13q14; by examining genes region, two microRNAs, miR-15a -16-1, appear as top candidates for elevated HbF levels. Indeed, increased...
Abstract FOXM1 , a known transcription factor, promotes cell proliferation in variety of cancer cells. Here we show that Foxm1 is required for survival, quiescence and self-renewal MLL-AF9 (MA9)-transformed leukemia stem cells (LSCs) vivo. Mechanistically, upregulation activates the Wnt/β-catenin signaling pathways by directly binding to β-catenin stabilizing protein through inhibiting its degradation, thereby preserving LSC quiescence, promoting MLL-rearranged AML. More importantly,...
Background During the final stages of differentiation mammalian erythroid cells, chromatin is condensed and enucleated. We previously reported that Rac GTPases their downstream target, homolog Drosophila diaphanous 2 (mDia2), are required for enucleation in vitro cultured mouse fetal liver erythroblasts. However, it not clear how condensation achieved whether enucleation.Design Methods Mouse erythroblasts were purified from embryonic day 14.5 pregnant mice erythropoietin-containing medium....
Myelofibrosis is characterized by bone marrow fibrosis, atypical megakaryocytes, splenomegaly, constitutional symptoms, thrombotic and hemorrhagic complications, a risk of evolution to acute leukemia. The JAK kinase inhibitor ruxolitinib provides therapeutic benefit, but the effects are limited. purpose this study was determine whether targeting AURKA, which has been shown increase maturation potential benefit for patients with myelofibrosis.Twenty-four myelofibrosis were enrolled in phase I...
Due to its high therapeutic efficiency and low systemic toxicity, natural bioactive curcumin has attracted more attention as a potential antineoplastic drug. Although the emergence of carrier-free nanocrystalline technology could improve solubility guarantee drug loading curcumin, uncontrollable release fast metabolism are definite obstacles that hinder further application in cancer treatment. Here, hyaluronic acid (HA) modification was carried out on surface nanocrystals (Cur-NC) obtain...
Myelodysplastic syndromes (MDS) are age-related myeloid neoplasms with increased risk of progression to acute leukemia (AML). The mechanisms transformation MDS AML poorly understood, especially in relation the aging microenvironment. We previously established an mDia1/miR-146a double knockout (DKO) mouse model phenocopying MDS. These mice develop pancytopenia oversecretion proinflammatory cytokines. Here, we found that most DKO underwent leukemic at 12-14 months age. showed myeloblast...
Inflammation leads to functional iron deficiency, by increasing the expression of hepatic regulatory peptide, hepcidin. also stimulates fibroblast growth factor 23 (FGF23) production both Fgf23 transcription and FGF23 cleavage, which paradoxically excess in C-terminal peptides (Cter-FGF23), rather than intact hormone (iFGF23). We determined that major source Cter-FGF23 are osteocytes investigated whether play a direct role regulation hepcidin metabolism response acute inflammation. Mice...
Terminal differentiation of mammalian erythroid progenitors involves 4-5 cell divisions and induction many important genes followed by chromatin nuclear condensation enucleation. The protein levels c-Myc (Myc) are reduced dramatically during late stage maturation, coinciding with cycle arrest in G(1) phase enucleation, suggesting possible roles for either or both these processes. Here we demonstrate that ectopic Myc expression affects terminal maturation a dose-dependent manner. Expression...
Anemia is characteristic of myelodysplastic syndromes (MDS). The mechanisms anemia in MDS are unclear. Using a mouse genetic approach, here we show that dual deficiency mDia1 and miR-146a, encoded on chromosome 5q commonly deleted (del(5q) MDS), causes an age-related ineffective erythropoiesis mimicking human MDS. We demonstrate the ageing bone marrow microenvironment important for development these mice. Damage-associated molecular pattern molecules (DAMPs), whose levels increase marrow,...
Even though the Ten-eleven translocation (TET) enzymes catalyze generation of 5-hydroxymethylcytosines required for lineage commitment and subsequent differentiation stem cells into erythroid cells, mechanisms that link extracellular signals to TET activation DNA hydroxymethylation are unknown. We demonstrate hematopoietic cytokines phosphorylate TET2, leading its in progenitors. Specifically, cytokine receptor-associated JAK2 phosphorylates TET2 at tyrosines 1939 1964. Phosphorylated...
The outbreak of coronavirus disease 2019 (COVID-19) in December overlaps with the flu season.We compared clinical and laboratory results from 719 influenza 973 COVID-19 patients January to April 2020. We compiled first 14 days hospitalized using parameters that are most significantly different between hierarchically clustered patients.Compared influenza, exhibited a continued increase white blood cell count, rapid decline hemoglobin, more urea nitrogen (BUN) D-dimer, higher level alanine...
Adipose tissue-derived stem cells (ADSCs) are a kind of with multi-directional differentiation potential, which mainly restore tissue repair function and promote cell regeneration. It can be directionally differentiated into Schwann-like to the peripheral nerve injury. Glial line-derived neurotrophic factor (GDNF) plays an important role in injury, but underlying mechanism remains unclear, seriously limits its further application.The study aimed identify molecular by overexpression glial...
Abstract The embankment and hill cut are conventional infrastructure scenarios along the railway line in windy regions. windbreak walls with same height separately installed on them to guarantee safety of train operation. However, due realistic terrain, distances from centerline not same, generating a wall transition causing sudden change windproof performance, which contributes called “yawing” phenomenon when passing through specified transition. current study aims predict flow...