A5060053570- Parathyroid Disorders and Treatments
- Dialysis and Renal Disease Management
- Chronic Kidney Disease and Diabetes
- Cardiovascular Function and Risk Factors
- Blood Pressure and Hypertension Studies
- Heart Failure Treatment and Management
- Fibroblast Growth Factor Research
- Magnesium in Health and Disease
- Diabetes Treatment and Management
- Vitamin D Research Studies
- Genetic Syndromes and Imprinting
- Cardiac Imaging and Diagnostics
- Iron Metabolism and Disorders
- Electrolyte and hormonal disorders
- Periodontal Regeneration and Treatments
- Hemoglobinopathies and Related Disorders
- Folate and B Vitamins Research
- Biomedical Research and Pathophysiology
- Oral microbiology and periodontitis research
- Dental Radiography and Imaging
- Hormonal Regulation and Hypertension
- Dental Anxiety and Anesthesia Techniques
- Connective tissue disorders research
- Dental Erosion and Treatment
- Cardiovascular Health and Risk Factors
Northwestern University
2016-2025
Manav Rachna International Institute of Research and Studies
2025
Jesse Brown VA Medical Center
2017-2024
University of Oxford
2023
Karnavati University
2020-2022
Sant Gadge Baba Amravati University
2020-2022
Gujarat University
2021
Institute of Public Health Zadar
2018-2019
RELX Group (United States)
2019
Hypertension Institute
2017-2018
Elevated fibroblast growth factor 23 (FGF23) levels, measured at a single time, are strongly associated with increased risk of mortality in patients CKD. There minimal data on serial FGF23 measurements In prospective case-cohort study the Chronic Renal Insufficiency Cohort, we two to five annual time points (mean 4.0±1.2) randomly selected subcohort 1135 participants, whom 203 died, and all remaining 390 participants who died through mid-2013. Higher was independently death...
<h3>Importance</h3> Levels of fibroblast growth factor 23 (FGF23) are elevated in chronic kidney disease (CKD) and strongly associated with left ventricular hypertrophy, heart failure, death. Whether FGF23 is an independent risk for atrial fibrillation CKD unknown. <h3>Objective</h3> To investigate the association CKD. <h3>Design, Setting, Participants</h3> Prospective cohort study 3876 individuals mild to severe who enrolled Chronic Renal Insufficiency Cohort Study between June 19, 2003,...
Significance Statement Evidence suggests that anemia and disordered mineral metabolism (including abnormalities in phosphate fibroblast growth factor 23 [FGF23]) contribute to adverse outcomes patients with advanced CKD. To investigate the effects of fixed-dose ferric citrate coordination complex such patients, authors randomly assigned 199 eGFR<20 ml/min per 1.73 m 2 2:1 or usual care. Treatment significantly increased hemoglobin, ferritin, transferrin saturation reduced FGF23, while...
Anemia is an early complication of CKD that associated with increased morbidity and mortality. Prior data show associations between abnormal mineral metabolism markers decreased erythropoiesis. However, few studies have investigated elevated fibroblast growth factor 23 as a risk for the development anemia in patients CKD.We conducted prospective cohort study 3869 individuals mild to severe enrolled Chronic Renal Insufficiency Cohort Study 2003 2008 followed through 2013. We hypothesized...
Significance Statement The secretion of organic solutes by the proximal tubules is an essential intrinsic kidney function. However, clinical significance clearance tubular secretory uncertain. In this prospective cohort study 3416 participants with CKD, authors found that lower clearances six endogenous are associated significantly greater risk CKD progression (defined as a ≥50% decline in eGFR from baseline, initiation maintenance dialysis, or transplantation) and four all-cause mortality...
Inflammation leads to functional iron deficiency, by increasing the expression of hepatic regulatory peptide, hepcidin. also stimulates fibroblast growth factor 23 (FGF23) production both Fgf23 transcription and FGF23 cleavage, which paradoxically excess in C-terminal peptides (Cter-FGF23), rather than intact hormone (iFGF23). We determined that major source Cter-FGF23 are osteocytes investigated whether play a direct role regulation hepcidin metabolism response acute inflammation. Mice...
While patients receiving dialysis therapy in the United States are more likely to develop cardiovascular disease (CVD) than those Japan, direct comparisons of with predialysis chronic kidney (CKD) rare. To study this, we compared various outcomes CKD using data from Chronic Renal Insufficiency Cohort (CRIC) and Japan (CKD-JAC) studies determined mediators any differences. Candidate included left ventricular (LV) indices assessed by echocardiography. Among 3125 CRIC 1097 CKD-JAC participants,...
Patients with CKD are at high risk for cardiovascular disease, ESKD, and mortality. Vascular calcification is one pathway through which disease risks increased. We hypothesized that a novel measure of serum propensity associated events, all-cause mortality among patients stages 2-4.Among 3404 participants from the prospective, longitudinal Chronic Renal Insufficiency Cohort Study, we quantified as transformation time (T50) primary to secondary calciprotein particles, lower T50 corresponding...
<h3>Importance</h3> Despite recent advances in therapies for heart failure (HF), deaths from HF are increasing, with persistent disparities between Black and White adults. Recent national trends the prevalence of need to be clarified appropriately allocate resources develop effective preventive interventions. <h3>Objectives</h3> To examine ambulatory overall by race/ethnicity age temporal changes 2001 2016. <h3>Design, Setting, Participants</h3> This cross-sectional study nationally...
Abstract Background and Aims Incident heart failure (HF) among individuals with chronic kidney disease (CKD) incurs hospitalizations that burden patients health care systems. There are few preventative therapies, the Pooled Cohort equations to Prevent Heart Failure (PCP-HF) perform poorly in setting of CKD. New drug targets better risk stratification urgently needed. Methods In this analysis incident HF, SomaScan V4.0 (4638 proteins) was analysed 2906 participants Chronic Renal Insufficiency...
Background Intercellular adhesion molecule-1 (ICAM-1) is a cell-surface protein that facilitates inflammation through leucocyte adhesion. Approximately 35% of Black individuals carry at least one copy an ICAM1 missense variant (rs5491; p.K56M), which has been associated with increased risk heart failure (HF) preserved ejection fraction (HFpEF). Whether the HFpEF conferred by rs5491 extends to chronic kidney disease (CKD), cohort high for HF, unknown. Aims We investigated association between...
<b>Background:</b> World-wide, the contribution of dental caries to burden oral diseases is about 10 times higher than that periodontal disease, other common condition. Owing its globally high prevalence, a pandemic disease characterized by percentage untreated carious cavities causing pain, discomfort and functional limitations. Untreated cavities; furthermore, have significant impact on general health children social economic well-being communities. A surgical approach elimination lesion...
IntroductionAbnormalities in lipid metabolism may contribute to the development and progression of chronic kidney disease (CKD) patients with type 2 diabetes. Fenofibrate induces early reversible reduction estimated glomerular filtration rate (eGFR), but it have protective effects on microvascular complications We hypothesized that randomization fenofibrate versus placebo would be associated beneficial long-term outcomes Action Control Cardiovascular Risk Diabetes (ACCORD) trial...
ABSTRACT Background Chronic kidney disease (CKD) is associated with atherosclerotic cardiovascular (ASCVD) risk, especially among those diabetes. Altered metabolism of solutes that accumulate in CKD [asymmetric dimethylarginine (ADMA), symmetric (SDMA) and trimethylamine N-oxide (TMAO)] may reflect pathways linking ASCVD. Methods This case–cohort study included Renal Insufficiency Cohort participants baseline diabetes, estimated glomerular filtration rate &lt;60 mL/min/1.73 m2, without...
Coronary artery calcification (CAC) progresses rapidly in people with chronic kidney disease (CKD) compared the general population. We studied association between CAC progression and higher risks of atherosclerotic cardiovascular (CVD), congestive heart failure, all-cause mortality among adults CKD. Prospective cohort study. 1,310 participants Chronic Renal Insufficiency Cohort (CRIC) Study who had at least 1 scan no prior history CVD observed or imputed data on changes over time. Observed...
Blacks have the highest prevalence of hypertension in United States. Higher levels FGF23 (fibroblast growth factor-23) been associated with worse cardiovascular outcomes. Whether is rising blood pressure (BP) and racial differences incident unclear. We studied 1758 adults (45.0±3.7 years; 57.8% female; 36.9% black) without or disease who participated year 20 (2005-2006) follow-up examination CARDIA study (Coronary Artery Risk Development Young Adults). investigated associations baseline...
Background and objectives Type 2 diabetes associated CKD disproportionately affect blacks. It is uncertain if racial disparities in type diabetes-associated are driven by biologic factors that influence propensity to or differences care. Design, setting, participants, & measurements We conducted a post hoc analysis of 1937 black 6372 white participants the Action Control Cardiovascular Risk Diabetes (ACCORD) trial examine associations race with change eGFR risks developing...
Background: Although FGF23 (fibroblast growth factor 23) is associated with heart failure and atrial fibrillation, the mechanisms driving these associations are unclear. Sensitive measures of cardiovascular structure function may provide mechanistic insight behind various diseases. Methods: In MESA (the Multi-Ethnic Study Atherosclerosis), we evaluated baseline serum (2000–2002) left ventricular (LV) mechanical on cardiac magnetic resonance at 10-year follow-up (2010–2012). Results: Of 2276...
Periodontal disease is one of the major causes alveolar bone loss. There are various ways regenerating lost bone, i.e. guided tissue regeneration, grafts, and growth factors. In this purview, it becomes immensely important for a clinician to decide best modality treatment. study, we compared effect demineralized freeze-dried allograft (DFDBA) in combination with concentrated factors (CGF) verses CGF alone.