A5086744652- Renal Transplantation Outcomes and Treatments
- Dialysis and Renal Disease Management
- Chronic Kidney Disease and Diabetes
- Organ Transplantation Techniques and Outcomes
- Blood Pressure and Hypertension Studies
- Erythropoietin and Anemia Treatment
- Potassium and Related Disorders
- Healthcare cost, quality, practices
- Organ Donation and Transplantation
- Health Systems, Economic Evaluations, Quality of Life
- Renal and Vascular Pathologies
- Polyomavirus and related diseases
- Transplantation: Methods and Outcomes
- Diabetes Management and Research
- Medication Adherence and Compliance
- Neurological Complications and Syndromes
- Mobile Health and mHealth Applications
- Organ and Tissue Transplantation Research
- Diabetes Treatment and Management
- Hemoglobinopathies and Related Disorders
- Healthcare Policy and Management
- Pharmaceutical Practices and Patient Outcomes
- Retinal Imaging and Analysis
- Renal function and acid-base balance
- Renal Diseases and Glomerulopathies
Children's Hospital of Philadelphia
2019-2024
The University of Texas at Dallas
2024
University of Maryland, Baltimore
2014-2023
Veterans Health Administration
2023
University of Maryland, Baltimore County
2020
University of Pennsylvania
2008-2019
Philadelphia University
2019
United States Department of Veterans Affairs
2017
University of Baltimore
2016
VA Maryland Health Care System
2007-2015
Among patients in the United States with chronic kidney disease, black are at increased risk for end-stage renal as compared white patients.In two studies, we examined effects of variants gene encoding apolipoprotein L1 (APOL1) on progression disease. In African American Study Kidney Disease and Hypertension (AASK), evaluated 693 disease attributed to hypertension. Chronic Renal Insufficiency Cohort (CRIC) study, 2955 (46% whom had diabetes) according whether they 2 copies high-risk APOL1...
Hyperkalemia is a potential threat to patient safety in chronic kidney disease (CKD). This study determined the incidence of hyperkalemia CKD and whether it associated with excess mortality.This retrospective analysis national cohort comprised 2 103 422 records from 245 808 veterans at least 1 hospitalization inpatient or outpatient serum potassium record during fiscal year 2005. Chronic treatment angiotensin-converting enzyme inhibitors and/or angiotensin II receptor blockers (blockers...
Insights into end-stage renal disease have emerged from many investigations but less is known about the epidemiology of chronic insufficiency (CRI) and its relationship to cardiovascular (CVD). The Chronic Renal Insufficiency Cohort (CRIC) Study was established examine risk factors for progression CRI CVD among patients develop models identify high-risk subgroups, informing future treatment trials, increasing application preventive therapies. CRIC will enroll approximately 3000 individuals...
The Chronic Renal Insufficiency Cohort (CRIC) Study was established to examine risk factors for the progression of chronic kidney disease (CKD) and cardiovascular (CVD) in patients with CKD. We examined baseline demographic clinical characteristics.Seven centers recruited adults who were aged 21 74 yr had CKD using age-based estimated GFR (eGFR) inclusion criteria. At baseline, blood urine specimens collected information regarding health behaviors, diet, quality life, functional status...
ABSTRACT. Polyoma virus (PV) can cause interstitial nephritis and lead to graft failure in renal transplant recipients. The clinical course of patients with polyoma (PVN) is not well understood, partially due its relatively low incidence. This study a retrospective analysis our experience over 4 yr. specific purpose outline the outcome PVN relationship between immunosuppression disease process. Between June 1997 March 2001, 67 dysfunction were found have biopsy-proven PVN. diagnosis was made...
This study set out to determine the incidence of hypoglycemia in patients with chronic kidney disease (CKD), and without diabetes, association mortality.This was a retrospective cohort analysis 243,222 who had 2,040,206 glucose measurements were cared for at Veterans Health Administration. CKD defined as an estimated GFR <60 ml/min per 1.73 m(2). Hypoglycemia <70 mg/dl. Mortality measured 1 day after measurement.The higher versus CKD. Among rate 10.72 5.33 100 patient-months among diabetes...
We determined whether laparoscopic living donor nephrectomy decreases the morbidity of renal donation for donor, while providing a allograft quality comparable to that open nephrectomy.In 3-year period was performed via transperitoneal approach. evaluated and recipient medical records preoperative characteristics, intraoperative parameters complications, postoperative recovery complications.Of 320 nephrectomies left kidney removed in 97.5%. Intraoperative which developed 10.4% cases, tended...
Background. The introduction of the potent immunosuppressive drugs tacrolimus (FK) and cyclosporine (CSA) has markedly improved outcome solid organ transplantation. However, these can cause posttransplantation diabetes mellitus. Abnormalities in glucose metabolism are particular significance pancreas Methods. We studied 26 allograft biopsies, performed 1-8 months posttransplantation, from 20 simultaneous kidney-pancreas transplant recipients, randomized to receive either FK or CSA. biopsies...
Quasi-experimental study designs, sometimes called nonrandomized, pre-post-intervention are ubiquitous in the infectious diseases literature, particularly area of interventions aimed at decreasing spread antibiotic-resistant bacteria. Little has been written about benefits and limitations quasi-experimental approach. This article outlines a hierarchy design that is applicable to studies that, if applied, may lead sounder research more-convincing causal links between outcomes.
Background. Laparoscopic donor nephrectomy (laparoNx) has the potential to increase living kidney donation rates by reducing pain and suffering of donor. However, renal function outcomes a large series recipients laparoNx have not been studied. Methods. We retrospectively reviewed records 132 done at our center between 3/96 11/97 compared them 99 kidneys procured open technique (openNx) 10/93 3/96. Results. Significantly more patients in group (25.2%) were taking tacrolimus within first...
Comorbidity is a known risk factor for antibiotic-resistant bacterial infections. Although aggregate comorbidity measures are useful in epidemiologic research, none of the existing was developed use with this outcome. This study compared utility two measures, Charlson Index and Chronic Disease Score, assessing comorbidity-attributable nosocomial infections methicillin-resistant Staphylococcus aureus (MRSA) or vancomycin-resistant enterococci (VRE). Two case-control studies were conducted at...
Summary Estimates suggest that one third of United States health care spending results from overuse or misuse tests, procedures, and therapies. The American Board Internal Medicine Foundation, in partnership with Consumer Reports , initiated the “Choosing Wisely” campaign to identify areas patient resource use most open improvement. Nine subspecialty organizations joined campaign; each organization identified five therapies are overused, misused, could potentially lead harm unnecessary...
Objective: To investigate the association between retinopathy and chronic kidney disease.Methods: In this observational, cross-sectional study, 2605 patients of Chronic Renal Insufficiency Cohort (CRIC) a multicenter study disease, were offered participation.Nonmydriatic fundus photographs disc macula in both eyes obtained 1936 these subjects.The reviewed masked fashion at central photograph reading center using standard protocols.Presence severity (diabetic, hypertensive, or other) vessel...
Traditional risk estimates for atherosclerotic vascular disease (ASVD) and death may not perform optimally in the setting of chronic kidney (CKD). We sought to determine whether addition measures inflammation function traditional estimation tools improves prediction these events a diverse cohort patients with CKD.
Export Background and objectives Previous studies suggest that tobacco, alcohol, illicit drug use is associated with CKD. We examined the associations of substance CKD progression all-cause mortality among patients Design, setting, participants, & measurements The Chronic Renal Insufficiency Cohort Study a prospective, longitudinal cohort study 3939 participants in United States. Self-reported tobacco smoking, alcohol drinking, marijuana use, hard (cocaine, heroin, or methamphetamine) were...