A5086851939- Vasculitis and related conditions
- Renal Diseases and Glomerulopathies
- Coagulation, Bradykinin, Polyphosphates, and Angioedema
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Otitis Media and Relapsing Polychondritis
- Cell Adhesion Molecules Research
- Sarcoidosis and Beryllium Toxicity Research
- Systemic Lupus Erythematosus Research
- Chronic Kidney Disease and Diabetes
- Autoimmune Bullous Skin Diseases
- Urticaria and Related Conditions
- Complement system in diseases
- Dialysis and Renal Disease Management
- Monoclonal and Polyclonal Antibodies Research
- Blood Coagulation and Thrombosis Mechanisms
- Atherosclerosis and Cardiovascular Diseases
- Inflammasome and immune disorders
- Renal Transplantation Outcomes and Treatments
- Heparin-Induced Thrombocytopenia and Thrombosis
- Amyloidosis: Diagnosis, Treatment, Outcomes
- Systemic Sclerosis and Related Diseases
- Eosinophilic Disorders and Syndromes
- Blood disorders and treatments
- Pregnancy and Medication Impact
- Mast cells and histamine
University of North Carolina at Chapel Hill
2016-2025
Emory University Hospital
2023
La Jolla Institute for Immunology
2022
University of North Carolina System
2021-2022
University of North Carolina Health Care
2013-2022
Vanderbilt University Medical Center
2022
Arkana Laboratories
2017-2019
Massachusetts General Hospital
2018
Indiana University School of Medicine
1991-2017
Ministry of Agriculture and Rural Development
2017
2012 Revised International Chapel Hill Consensus Conference Nomenclature of Vasculitides J. Jennette;R. Falk;P. Bacon;N. Basu;M. Cid;F. Ferrario;L. Flores-Suarez;W. Gross;L. Guillevin;E. Hagen;G. Hoffman;D. Jayne;C. Kallenberg;P. Lamprecht;C. Langford;R. Luqmani;A. Mahr;E. Matteson;P. Merkel;S. Ozen;C. Pusey;N. Rasmussen;A. Rees;D. Scott;U. Specks;J. Stone;K. Takahashi;R. Watts; Arthritis & Rheumatism
Anti-neutrophil cytoplasmic autoantibodies have been found in patients with systemic arteritis and glomerulonephritis. We studied the disease distribution antigen specificity of these autoantibodies. were identified by indirect immunofluorescence microscopy 27 35 idiopathic necrotizing crescentic glomerulonephritis, whom manifestations ranged from injury limited to kidney arteritis. The incidence titers did not differ between those disease. immunostaining was detected 5 11 lupus nephritis, 4...
Anti-neutrophil cytoplasmic autoantibodies (ANCA) are in the circulation of most patients with pauci-immune necrotizing vasculitis and crescentic glomerulonephritis. The current study demonstrates an effect these on neutrophil function vitro. ANCA cause normal human neutrophils to undergo oxidative burst degranulate. Both phenotypes (i.e., cytoplasmic-pattern myeloperoxidase-specific ANCA) induce activation. sera purified immunoglobulins significantly increase release reactive oxygen species...
Antineutrophil cytoplasmic autoantibodies (ANCAs) are identified in the circulation of approximately 80% patients with pauci-immune necrotizing and crescentic glomerulonephritis systemic small vessel vasculitis, such as microscopic polyangiitis Wegener granulomatosis. The most common antigen target for ANCAs is myeloperoxidase (MPO), which found neutrophils monocytes. We report definitive experimental animal evidence that pathogenic. MPO knockout (Mpo(-/-)) mice were immunized mouse MPO....
Antineutrophil cytoplasmic autoantibodies (ANCAs) are identified in the circulation of approximately 80% patients with pauci-immune necrotizing and crescentic glomerulonephritis systemic small vessel vasculitis, such as microscopic polyangiitis Wegener granulomatosis. The most common antigen target for ANCAs is myeloperoxidase (MPO), which found neutrophils monocytes. We report definitive experimental animal evidence that pathogenic. MPO knockout (Mpo–/–) mice were immunized mouse MPO....
Predictors of treatment resistance and relapse have not been well described in antineutrophil cytoplasmic antibody (ANCA)-associated small-vessel vasculitis.To identify clinical, pathologic, serologic predictors a community-based cohort patients with ANCA-associated vasculitis.Cohort identified at or near the time biopsy diagnosis followed as clinically indicated.The Glomerular Disease Collaborative Network.350 who received new vasculitis between 1985 2003 were for median 49 months.Patients...
Objectives: To determine the spectrum of clinical manifestations in patients with anti-neutrophil cytoplasmic autoantibody (ANCA)-associated glomerulonephritis; to renal and patient survival these patients; compare among treated corticosteroids alone, plus intravenous cyclophosphamide or oral cyclophosphamide; assess correlation disease treatment response ANCA subtypes serial titers. Design: Inception cohort study; mean follow-up 24 months. Setting: Collaborative network 120 university...
Abstract Objective To compare the usefulness of 3 currently used classification systems in predicting outcomes treatment resistance, disease relapse, end‐stage renal (ESRD), and death patients with antineutrophil cytoplasmic antibody (ANCA)–associated vasculitis (AAV). Methods Three were applied to 502 biopsy‐proven AAV: 1) Chapel Hill Consensus Conference (CHCC) definition categories for granulomatosis polyangiitis (GPA) (Wegener's), microscopic (MPA), kidney‐limited disease; 2) European...
The purpose of this study was to determine the prognostic value clinical, laboratory, and pathologic features at time presentation on patient renal survival in patients with antineutrophil cytoplasmic autoantibody (ANCA)-associated microscopic polyangiitis glomerulonephritis (excluding Wegener's granulomatosis). One hundred seven ANCA-positive necrotizing crescentic glomerulonephritis, including 69 evidence for polyangiitis, were evaluated study. relative risk death calculated following...
Necrotizing and crescentic GN (NCGN) with a paucity of glomerular immunoglobulin deposits is associated ANCA. The most common ANCA target antigens are myeloperoxidase (MPO) proteinase 3. In manner that requires activation the alternative complement pathway, passive transfer antibodies to mouse MPO (anti-MPO) induces model NCGN closely mimics human disease. Here, we confirm importance C5aR/CD88 in mediation anti-MPO-induced report C6 not required. We further demonstrate deficiency C5a-like...
The Boards of Directors the American College Rheumatology (ACR), Society Nephrology (ASN) and European League Against Rheumatism (EULAR) have recommended a gradual shift from honorific eponyms to disease-descriptive or aetiology-based nomenclature. The leadership these three organizations tasked an international group senior academicians expert in care patients with vasculitis engaged research field provide medical community proper descriptive terms instead names for Wegener's...
Anti-neutrophil cytoplasmic antibody–associated (ANCA-associated) small vessel necrotizing vasculitis is caused by immune-mediated inflammation of the wall and diagnosed in some cases presence myeloperoxidase-specific antibodies (MPO-ANCA). This multicenter study sought to determine whether differences ANCA epitope specificity explain why, cases, conventional serologic assays do not correlate with disease activity, why naturally occurring anti-MPO autoantibodies can exist disease-free...
Persons with toxic gain-of-function variants in the gene encoding apolipoprotein L1 (APOL1) are at greater risk for development of rapidly progressive, proteinuric nephropathy. Despite known genetic cause, therapies targeting kidney disease persons two APOL1 (G1 or G2) lacking. Download a PDF Research Summary. We used tetracycline-inducible human embryonic (HEK293) cells to assess ability small-molecule compound, inaxaplin, inhibit channel function. An G2–homologous transgenic mouse model...