A5079025831- Parathyroid Disorders and Treatments
- Genetic Syndromes and Imprinting
- Insect Utilization and Effects
- Iron Metabolism and Disorders
- Educational Innovations and Challenges
- Higher Education Learning Practices
- Heterotopic Ossification and Related Conditions
- Plant Parasitism and Resistance
- Pharmaceutical and Antibiotic Environmental Impacts
- Plant and animal studies
- Moringa oleifera research and applications
- Mycorrhizal Fungi and Plant Interactions
- Higher Education Governance and Development
Northwestern University
2023
Inflammation leads to functional iron deficiency, by increasing the expression of hepatic regulatory peptide, hepcidin. also stimulates fibroblast growth factor 23 (FGF23) production both Fgf23 transcription and FGF23 cleavage, which paradoxically excess in C-terminal peptides (Cter-FGF23), rather than intact hormone (iFGF23). We determined that major source Cter-FGF23 are osteocytes investigated whether play a direct role regulation hepcidin metabolism response acute inflammation. Mice...
Fibroblast growth factor 23 (FGF23) is a phosphate (Pi)-regulating hormone produced by bone. Hereditary hypophosphatemic disorders are associated with FGF23 excess, impaired skeletal and osteomalacia. Blocking became an effective therapeutic strategy in X-linked hypophosphatemia, but testing remains limited autosomal recessive rickets (ARHR). This study investigates the effects of Pi repletion bone specific deletion Fgf23 on mineral metabolism Dmp1 knockout (Dmp1KO) mouse model ARHR.At 12...