A5013580869- Bone health and osteoporosis research
- Bone Metabolism and Diseases
- Hip and Femur Fractures
- Bone health and treatments
- Vitamin D Research Studies
- Nutrition and Health in Aging
- Neonatal Respiratory Health Research
- Bone and Joint Diseases
- Hip disorders and treatments
- Nutritional Studies and Diet
- Body Composition Measurement Techniques
- Bone fractures and treatments
- Lymphoma Diagnosis and Treatment
- Cerebral Palsy and Movement Disorders
- Respiratory Support and Mechanisms
- Neuroscience of respiration and sleep
- Hydraulic and Pneumatic Systems
- Parathyroid Disorders and Treatments
- Cavitation Phenomena in Pumps
- Meta-analysis and systematic reviews
- Fluid Dynamics Simulations and Interactions
- Renin-Angiotensin System Studies
- Cancer Mechanisms and Therapy
- Calcium signaling and nucleotide metabolism
- CNS Lymphoma Diagnosis and Treatment
Murdoch Children's Research Institute
2021-2024
Tianjin Medical University Cancer Institute and Hospital
2015-2024
Dalian University of Technology
2024
National Clinical Research
2024
Wenzhou Medical University
2024
First Affiliated Hospital of Wenzhou Medical University
2024
Nanjing Agricultural University
2016-2023
The University of Melbourne
2010-2022
Austin Health
2009-2021
Royal Children's Hospital
2021
Bacterial communities associated with plant roots play an important role in the suppression of soil-borne pathogens, and multispecies probiotic consortia may enhance disease efficacy. Here we introduced defined Pseudomonas species into naturally complex microbial measured importance community diversity for their survival bacterial pathogen Ralstonia solanacearum tomato rhizosphere microbiome. The increased increasing diversity. Further, high reduced density decreased incidence due to both...
<h3>Importance</h3> The benefits of surfactant administration via a thin catheter (minimally invasive therapy [MIST]) in preterm infants with respiratory distress syndrome are uncertain. <h3>Objective</h3> To examine the effect selective application MIST at low fraction inspired oxygen threshold on survival without bronchopulmonary dysplasia (BPD). <h3>Design, Setting, and Participants</h3> Randomized clinical trial including 485 gestational age 25 to 28 weeks who were supported continuous...
Abstract The structural basis for sex differences in femoral neck (FN) fragility was studied 1196 subjects and 307 patients with hip fracture. absolute relative patterns of modeling remodeling on the periosteal endocortical envelopes during growth aging produce changes FN geometry structure that results both sexes sexual dimorphism fracture risk old age. Introduction: Femoral age is usually attributed to age-related bone loss, while rate are less loss men than women. purpose this study...
To assess the antifracture efficacy and safety of a nutritional intervention in institutionalised older adults replete vitamin D but with mean intakes 600 mg/day calcium <1 g/kg body weight protein/day.Two year cluster randomised controlled trial.60 accredited residential aged care facilities Australia housing predominantly ambulant residents.7195 permanent residents (4920 (68%) female; age 86.0 (SD 8.2) years).Facilities were stratified by location organisation, 30 to provide additional...
Fractures of the distal radius in children have a similar incidence to that found postmenopausal women but occur more commonly boys than girls. tibia are uncommon and show no sex specificity. About 90% lengthening only 30% during puberty at growth plate. We speculated rapid modeling radial metaphysis results greater dissociation between mineral accrual observed tibia. measured macro- microarchitecture tibial using high-resolution peripheral quantitative computed tomography cross-sectional...
ABSTRACT Fragility fractures commonly involve metaphyses. The distal radius is assembled with a thin cortex formed by fusion (corticalization) of trabeculae arising from the periphery growth plate. Centrally positioned reinforce and transfer loads joint to proximal thicker cortical bone. We hypothesized that growth- age-related deficits in trabecular bone disrupt this frugally microarchitecture, producing fragility. microarchitecture was measured using high-resolution peripheral quantitative...
Abstract A common genetic form of Parkinson's disease (PD) is caused by mutations in LRRK2. We identify WSB1 as a LRRK2 interacting protein. ubiquitinates through K27 and K29 linkage chains, leading to aggregation neuronal protection primary neurons Drosophila model G2019S Knocking down endogenous exacerbates mutant toxicity the model, indicating role for modulating cell toxicity. Lewy bodies human PD post-mortem tissue. These data demonstrate pathogenesis, suggest involvement body pathology...
ABSTRACT Estrogen deficiency associated with menopause is accompanied by an increase in the rate of bone remodeling and appearance a imbalance; each greater number transactions deposits less than was resorbed, resulting microstructural deterioration. The newly deposited also completely mineralized older resorbed. We examined whether breastfeeding, estrogen-deficient state, compromises microstructure matrix mineral density. Distal tibial distal radial microarchitecture were quantified using...
The long-term effects of surfactant administration via a thin catheter (minimally invasive therapy [MIST]) in preterm infants with respiratory distress syndrome remain to be definitively clarified.
Abstract To identify the racial differences in macro- and microstructure of distal radius tibia that may account for lower fracture rates Asians than whites, we studied 61 healthy premenopausal Chinese 111 white women 18–45 yr age using high-resolution pQCT (HR-pQCT). The were shorter leaner. Distal total cross-sectional area (CSA) was 14.3% smaller because an 18.0% trabecular (p &lt; 0.001). Cortical thickness 8.8% greater Chinese, but cortical no different. Total volumetric BMD (vBMD)...
ABSTRACT After menopause, remodeling becomes unbalanced and rapid. Each of the many transactions deposits less bone than it resorbed, producing microstructural deterioration. Trabecular is said to be lost more rapidly cortical bone. However, because 80% skeleton cortical, we hypothesized that most menopause-related loss changes in microstructure are not trabecular origin, result intracortical remodeling. Distal tibial distal radial were quantified during 3.1 years (range, 1.5 4.5 years)...
ABSTRACT All genetic and environmental factors contributing to differences in bone structure between individuals mediate their effects through the final common cellular pathway of modeling remodeling. We hypothesized that account for most population variance cortical trabecular microstructure, particular intracortical porosity medullary size – void volumes (porosity), which establish internal surface areas or interfaces upon remodeling deposit remove configure microarchitecture....
Gender-affirming hormone therapy aligns physical characteristics with an individual's gender identity, but sex hormones regulate bone remodeling and influence morphology. We hypothesized that trans men receiving testosterone have compromised morphology because of suppression ovarian estradiol production, whereas women estradiol, or without anti-androgen therapy, preserved microarchitecture. compared distal radial tibial microarchitecture using high-resolution peripheral quantitative computed...
This study investigates cloud cavitation suppression around a model-scale NACA66 hydrofoil using active water injection and explores the effect of multiple parameters. Numerical simulations mixed-level orthogonal test method are employed to systematically analyze impact jet angle αjet, location Ljet, velocity Ujet on efficiency energy performance. The reveals that has greatest influence suppression, while optimal parameter combination (Ljet = 0.30C, αjet +60 degrees, 3.25 m/s) effectively...
Few studies have examined long-term outcomes following oral immunotherapy (OIT); none risks and benefits associated with distinct clinical (desensitization, remission).
Skeletal fragility is common at metaphyseal regions of long bones. The cortices this region are derived by coalescence trabeculae around the periphery growth plate, not periosteal apposition, as occurs in diaphyses. We therefore hypothesized that trabecular bone childhood predicted both cortical and morphology adulthood. To test hypothesis, we measured distal radial tibial structure using high-resolution peripheral quantitative computed tomography 61 daughter-mother pairs, mean age 12.5...
Abstract Malnutrition in institutionalised elderly increases morbidity and care costs. Meat dairy foods are high-quality protein sources so adequate intakes may reduce malnutrition risk. We aimed to determine whether inadequate of meat contribute elderly. This cross-sectional study involved 215 residents (70·2 % females, mean age 85·8 years) from twenty-one aged-care facilities Melbourne, Australia. Dietary intake was assessed using observed plate waste. Food groups serving sizes were based...
Abstract Context Patients with glucocorticoid-dependent Duchenne muscular dystrophy (DMD) have increased fracture risk and reduced bone mineral density (BMD), often precipitating mobility loss. Objective To investigate use of zoledronic acid (ZA) in DMD improving BMD. Methods Two arm, parallel, randomized controlled trial, set pediatric hospitals across Australia New Zealand. Sixty-two (31 per arm) boys between 6 16 years were included. Five ZA infusions (0.025 mg/kg at months 0, 3, 0.05 6,...