A5014835903- Bone health and osteoporosis research
- Hip and Femur Fractures
- Bone and Joint Diseases
- Bone fractures and treatments
- Bone health and treatments
- Bone Metabolism and Diseases
- Hip disorders and treatments
- Body Composition Measurement Techniques
- Birth, Development, and Health
- Nutrition and Health in Aging
- Gestational Diabetes Research and Management
- Pregnancy and preeclampsia studies
- Hormonal and reproductive studies
- Reproductive tract infections research
- Congenital Anomalies and Fetal Surgery
- Vitamin D Research Studies
- Pelvic and Acetabular Injuries
- Maternal and Perinatal Health Interventions
- Parathyroid Disorders and Treatments
- Estrogen and related hormone effects
- Hemoglobinopathies and Related Disorders
- Artificial Intelligence in Healthcare and Education
- Acute Ischemic Stroke Management
- Chronic Kidney Disease and Diabetes
- Human Health and Disease
Oslo University Hospital
2021-2025
NORCE Norwegian Research Centre
2021-2025
UiT The Arctic University of Norway
2015-2024
University Hospital of North Norway
2012-2024
Posten (Norway)
2024
Vestre Viken Hospital Trust
2020
Smerteklinikken
2002-2020
Drammen Hospital
2020
Institutt for Eksperimentell Medisinsk Forskning
2020
University of Oslo
2020
The role played by endogenous hormones in many diseases makes it important to understand factors influencing their levels. This study examined the distribution of total and free estradiol, FSH, dehydroepiandrosterone sulfate (DHEAS) age sex associations these with body mass index (BMI), lifestyle factors, chronic diseases. Plasma samples taken from 1555 men 1952 women 25–84 yr 1994–1995 Tromsø Study were analyzed 2001. Total estradiol increased among (P < 0.001), or without adjustment for...
ABSTRACT Most fragility fractures arise among the many women with osteopenia, not smaller number osteoporosis at high risk for fracture. Thus, most fracture assessed only by measuring areal bone mineral density (aBMD) will remain untreated. We measured cortical porosity and trabecular volume/total volume (BV/TV) of ultradistal radius (UDR) using high-resolution peripheral quantitative computed tomography, aBMD densitometry, 10-year probability country-specific assessment tool (FRAX) in 68...
ABSTRACT Taller women are at increased risk for fracture despite having wider bones that better tolerate bending. Because require less material to achieve a given bending strength, we hypothesized taller assemble with relatively thinner and more porous cortices because excavation of larger medullary canal may be accompanied by intracortical canals. Three-dimensional images distal tibia, fibula, radius were obtained in vivo using high-resolution peripheral quantitative computed tomography...
ABSTRACT The risk of subsequent fracture is increased after initial fractures; however, proper understanding its magnitude lacking. This population-based study examines the in women and men by age type incident fracture. All nonvertebral fractures between 1994 2009 were registered 27,158 participants Tromsø Study, Norway. analysis included 3108 subjects with an 49 years. Subsequent (n = 664) was expressed as rate ratios (RR) absolute proportions irrespective death. rates both age, latter...
ABSTRACT Estrogen deficiency associated with menopause is accompanied by an increase in the rate of bone remodeling and appearance a imbalance; each greater number transactions deposits less than was resorbed, resulting microstructural deterioration. The newly deposited also completely mineralized older resorbed. We examined whether breastfeeding, estrogen-deficient state, compromises microstructure matrix mineral density. Distal tibial distal radial microarchitecture were quantified using...
We tested whether cortical porosity of the proximal femur measured using StrAx1.0 software provides additional information to areal bone mineral density (aBMD) or Fracture Risk Assessment Tool (FRAX) in differentiating women with and without fracture. Porosity was associated fracture independent aBMD FRAX identified fractures than by osteoporosis thresholds.Neither nor captures porosity, a major determinant strength. therefore combining improves identification fractures.We quantified femoral...
Despite reported bone loss during pregnancy and lactation, no study has shown deleterious long-term effects of parity or breastfeeding. Studies have higher mineral density reduced risk for fracture in parous than nulliparous women effect breastfeeding, so are uncertain. We studied the breastfeeding on hip, wrist non-vertebral fragility fractures (hip, wrist, proximal humerus) 4681 postmenopausal aged 50 to 94 years Tromsø Study from 1994-95 2010, using Cox's proportional hazard models....
Objectives : As bone fragility is partly the result of sex hormone deficiency, we sought to determine whether circulating steroids or hormone-binding globulin (SHBG) predicts non-vertebral fractures. Methods Forearm mineral density (BMD), total estradiol and testosterone, calculated free levels, SHBG were measured in 1386 postmenopausal women 1364 men aged 50–84 years at baseline Tromsø Study (1994–1995). Non-vertebral fractures documented between 1994 2005. Results During 8.4 (range...
Background Absolute risk estimation is a preferred approach for assessing fracture and treatment decision making. This study aimed to evaluate validate the predictive performance of Garvan Fracture Risk Calculator in Norwegian cohort. Methods The analysis included 1637 women 1355 aged 60+ years from Tromsø study. All incident fragility fractures between 2001 2009 were registered. predicted probabilities non-vertebral osteoporotic hip determined using models with without BMD. discrimination...
ABSTRACT After menopause, remodeling becomes unbalanced and rapid. Each of the many transactions deposits less bone than it resorbed, producing microstructural deterioration. Trabecular is said to be lost more rapidly cortical bone. However, because 80% skeleton cortical, we hypothesized that most menopause-related loss changes in microstructure are not trabecular origin, result intracortical remodeling. Distal tibial distal radial were quantified during 3.1 years (range, 1.5 4.5 years)...
An international workshop on vaginal smear-based diagnosis of bacterial vaginosis was organized where 13 investigators scoring 258 slides with smears from fluid. Interobserver reproducibility interpretations Nugent scores, Hay/Ison scores and wet smear for the shown to be high. Detailed analysis individual results however indicated that basic standards quality control ensure robust readings must adhered to.
Context: Seasonal variation in daylight regulates reproduction animals living at higher latitude, but the influence of season on sex hormones humans remains unclear. Objective, Design, and Participants: A cross-sectional population-based study Tromsø, Norway (70° N) included 1651 women 1540 men aged 25–84 yr. Circulating total estradiol (and calculated free levels), FSH, dehydroepiandrosterone sulfate (DHEAS) were measured between September 1994 1995 provided a unique opportunity to effects...
ABSTRACT All genetic and environmental factors contributing to differences in bone structure between individuals mediate their effects through the final common cellular pathway of modeling remodeling. We hypothesized that account for most population variance cortical trabecular microstructure, particular intracortical porosity medullary size – void volumes (porosity), which establish internal surface areas or interfaces upon remodeling deposit remove configure microarchitecture....