Lars Nordsletten

ORCID: 0000-0003-4642-5787
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About
Contact & Profiles
Research Areas
  • Orthopaedic implants and arthroplasty
  • Total Knee Arthroplasty Outcomes
  • Hip and Femur Fractures
  • Hip disorders and treatments
  • Bone health and osteoporosis research
  • Bone fractures and treatments
  • Osteoarthritis Treatment and Mechanisms
  • Orthopedic Infections and Treatments
  • Sports injuries and prevention
  • Winter Sports Injuries and Performance
  • Knee injuries and reconstruction techniques
  • Pelvic and Acetabular Injuries
  • Cardiac, Anesthesia and Surgical Outcomes
  • Bone health and treatments
  • Lower Extremity Biomechanics and Pathologies
  • Orthopedic Surgery and Rehabilitation
  • Shoulder Injury and Treatment
  • Bone and Joint Diseases
  • Tendon Structure and Treatment
  • Inflammatory mediators and NSAID effects
  • Cardiac Ischemia and Reperfusion
  • Musculoskeletal pain and rehabilitation
  • Injury Epidemiology and Prevention
  • Muscle activation and electromyography studies
  • Bone Metabolism and Diseases

Oslo University Hospital
2016-2025

University of Oslo
2016-2025

Sørlandet Sykehus
2019

Faculty (United Kingdom)
2019

Orthopedic One
2019

Clinical Orthopaedics and Related Research
2018

Committee on Publication Ethics
2018

Trøndelag Forskning og Utvikling (Norway)
2018

Norwegian School of Sport Sciences
2009-2015

Oslo Sports Trauma Research Center
2009-2015

Mortality is increased after a hip fracture, and strategies that improve outcomes are needed.In this randomized, double-blind, placebo-controlled trial, 1065 patients were assigned to receive yearly intravenous zoledronic acid (at dose of 5 mg), 1062 placebo. The infusions first administered within 90 days surgical repair fracture. All (mean age, 74.5 years) received supplemental vitamin D calcium. median follow-up was 1.9 years. primary end point new clinical fracture.The rates any fracture...

10.1056/nejmoa074941 article EN New England Journal of Medicine 2007-09-19

Displaced femoral neck fractures usually are treated with hemiarthroplasty. However, the degree to which design of implant used (cemented or uncemented) affects outcome is not known and may be therapeutically important.In this randomized controlled trial, we sought compare cemented cementless fixation in bipolar hemiarthroplasties at 5 years terms (1) Harris hip scores; (2) fractures; (3) overall health outcomes using Barthel Index EQ-5D (4) complications, reoperations, mortality since our...

10.1007/s11999-013-3308-9 article EN Clinical Orthopaedics and Related Research 2013-09-30

<b>Objective</b> To compare the functional results after displaced fractures of femoral neck treated with internal fixation or hemiarthroplasty. <b>Design</b> Randomised trial blinding assessments results. <b>Setting</b> University hospital. <b>Participants</b> 222 patients; 165 (74%) women, mean age 83 years. Inclusion criteria were above 60, ability to walk before fracture, and no major hip pathology, regardless cognitive function. <b>Interventions</b> Closed reduction two parallel screws...

10.1136/bmj.39399.456551.25 article EN BMJ 2007-12-04

Hemiarthroplasty is the most commonly used treatment for displaced femoral neck fractures in elderly. There limited evidence literature of improved functional outcome with cemented implants, although serious cement-related complications have been reported. We performed a randomized, controlled trial patients 70 years and older comparing implant (112 hips) an uncemented, hydroxyapatite-coated (108 hips), both bipolar head. The mean Harris hip score showed equivalence between groups, 70.9...

10.1007/s11999-008-0672-y article EN Clinical Orthopaedics and Related Research 2009-01-06

There is limited insight into the mechanisms of anterior cruciate ligament injuries in alpine skiing, particularly among professional ski racers.This study was undertaken to qualitatively describe injury World Cup skiing.Case series; Level evidence, 4.Twenty cases reported through International Ski Federation Injury Surveillance System for 3 consecutive seasons (2006-2009) were obtained on video. Seven international experts field skiing biomechanics and sports medicine related performed...

10.1177/0363546511405147 article EN The American Journal of Sports Medicine 2011-04-22

Background: Limited knowledge exists on injuries among professional alpine skiers. Objective: To describe the risk of injury and pattern competitive World Cup skiers during season. Methods: Retrospective interviews were performed with all athletes from 10 nations at end 2006–7 2007–8 winter seasons, acute occurring 4.5-month season recorded. If athlete was not present, their coaches or medical personnel interviewed. Results: A total 191 recorded 521 As many as 86 (45%) occurred Cup/World Ski...

10.1136/bjsm.2009.068759 article EN British Journal of Sports Medicine 2009-11-27

Background: The use of recombinant human bone morphogenetic protein-2 (rhBMP-2) to improve the healing open tibial shaft fractures has been focus two prospective clinical studies. objective current study was perform a subgroup analysis combined data from these Methods: Two prospective, randomized studies were conducted. A total 510 patients with receive control treatment (intramedullary nail fixation and routine soft-tissue management) or an absorbable collagen sponge impregnated one...

10.2106/jbjs.e.00499 article EN Journal of Bone and Joint Surgery 2006-06-01

<h3>Background</h3> Many patients with lung cancer are deconditioned poor physical fitness. Lung resection reduces fitness further, impairing the patient9s ability to function in daily life. <h3>Methods</h3> We conducted a single-blind randomised controlled trial of high-intensity endurance and strength training (60 min, three times week, 20 weeks), starting 5–7 weeks after surgery. The control group received standard postoperative care. primary outcome was change peak oxygen uptake measured...

10.1136/thoraxjnl-2014-205944 article EN Thorax 2014-10-16

Annual infusions of zoledronic acid (5 mg) significantly reduced the risk vertebral, hip, and nonvertebral fractures in a study postmenopausal women with osteoporosis clinical all-cause mortality another men who had recently undergone surgical repair hip fracture. In this analysis, we examined whether timing first infusion drug after fracture influenced antifracture efficacy benefit observed study. A total 2127 patients (1065 on active treatment 1062 placebo; mean age, 75 yr; 76% 24% men)...

10.1359/jbmr.090209 article EN Journal of Bone and Mineral Research 2009-03-03

There is little information available on injuries to World Cup skiers and snowboarders. The aim of this study was describe compare the injury risk athletes in alpine skiing, freestyle snowboarding, ski jumping, Nordic combined cross country skiing. We performed retrospective interviews with International Ski Federation (FIS) from selected nations during 2006-2007 2007-2008 winter seasons recorded all acute occurring seasons. interviewed 2121 705 injuries. were 520 (72%) time-loss 196 (28%)...

10.1111/j.1600-0838.2010.01147.x article EN Scandinavian Journal of Medicine and Science in Sports 2010-06-18

Background Exercise treatment is recommended for all patients with hip osteoarthritis (OA), but its effect on the long-term need total replacement (THR) unknown. Methods We conducted a follow-up of randomised trial investigating efficacy exercise therapy and patient education versus only 6-year cumulative survival native to THR in 109 symptomatic radiographic OA. Results regarding primary outcome measure trial, self-reported pain at 16 months follow-up, have been reported previously. There...

10.1136/annrheumdis-2013-203628 article EN cc-by-nc Annals of the Rheumatic Diseases 2013-11-19

Existent biomechanical studies on hip osteoarthritic gait have primarily focused the end stage of disease. Consequently, there is no clear consensus which specific parameters are most relevance for osteoarthritis patients with mild to moderate symptoms. The purpose this study was explore sagittal plane characteristics during stance phase in not eligible replacement surgery. First, compared healthy controls, and second, when categorized into two subgroups radiographic severity defined from a...

10.1186/1471-2474-13-258 article EN cc-by BMC Musculoskeletal Disorders 2012-12-01

Background — The surgical approach in total hip arthroplasty (THA) is often based on surgeon preference and local traditions. anterior muscle-sparing has recently gained popularity Europe. We tested the hypothesis that patient satisfaction, pain, function, health-related quality of life (HRQoL) after THA not related to approach.Patients 1,476 patients identified through Norwegian Arthroplasty Register were sent questionnaires 1–3 years undergoing period from January 2008 June 2010....

10.3109/17453674.2014.934183 article EN cc-by-nc Acta Orthopaedica 2014-06-23

Background In competitive alpine skiing, there is a controversy regarding the sex-related risk of injury. Objective To compare injury in female versus male World Cup (WC) skiers. Methods Injuries were recorded through International Ski Federation Injury Surveillance System for six consecutive winter seasons (2006–2012), based on retrospective interviews with athletes from 10 teams at end each season. All acute training and competition injuries which required medical attention recorded. Race...

10.1136/bjsports-2013-092206 article EN British Journal of Sports Medicine 2013-05-14

It is proposed that the use of biochemical markers for muscle damage and inflammation provides an objective measure on invasiveness in total hip arthroplasty. We analyzed levels creatine kinase C-reactive protein (CRP) after arthroplasty patients randomized to minimally invasive direct anterior approach or lateral approach, also recording consumption pain medication postoperatively. Eighty-three were operated by eighty using lateral. Creatine CRP measured preoperatively, directly surgery,...

10.1002/jor.22911 article EN Journal of Orthopaedic Research® 2015-04-16

BackgroundMinimally invasive fusion of the sacroiliac joint as treatment for low back pain may reduce and improve function compared to non-operative treatment, although clear evidence is lacking. The aim this trial was evaluate effect minimally sham surgery on reduction.MethodsIn double-blind randomized surgery-controlled patients with clinical diagnosis confirmed injection were included at two university hospitals in Sweden Norway. Patients by operating surgeon each site or surgery. primary...

10.1016/j.eclinm.2024.102438 article EN cc-by EClinicalMedicine 2024-02-01

Abstract Objective To identify prospectively the possible risk factors for total hip replacement (THR) due to primary osteoarthritis in a large cohort. Methods Data from cardiovascular screening were matched with 9 years of national data on THR. Mean age at start followup was 54.9 years, and 50,034 participants followed up an average years. During followup, 672 persons had first THR osteoarthritis. Results We found dose‐response associations between body mass index (BMI), weight, level...

10.1002/art.10115 article EN Arthritis & Rheumatism 2002-03-01

Abstract Objective To investigate the effects of body mass index (BMI), height, and age on risk later total hip arthroplasty for primary osteoarthritis (OA). Methods We matched screening data height weight from 1,152,006 persons ages 18–67 years who attended a compulsory tuberculosis in 1963–1975 with Norwegian Arthroplasty Register 1987–2003. identified 28,425 replacements because OA. Results found dose‐response associations between both BMI arthroplasty. The relative (RR) among men ≥32...

10.1002/art.21659 article EN Arthritis & Rheumatism 2006-02-28

No long-term injury surveillance programs exist for competitive skiing or snowboarding. The objective of this study was, therefore, to compare different methods record injuries among World Cup athletes in alpine, freestyle, and cross-country skiing, snowboarding, ski jumping Nordic combined. Information regarding sustained during the 2006-2007 winter season was recorded through three separate independent systems: prospective reports by technical delegates (TD) from International Ski...

10.1111/j.1600-0838.2009.01048.x article EN Scandinavian Journal of Medicine and Science in Sports 2009-12-18

Background: Since 2008, there has been an increase in the use of minimally invasive surgery (MIS) through anterior or anterolateral approach for total hip arthroplasty (THA) Norway. We compared MIS approaches with conventional posterior and direct lateral terms revision rates risk revision. Methods: On basis data Norwegian Arthroplasty Register, 21,860 THAs uncemented stem, performed between 2008 2013, were identified included cohort. Of these THAs, 2,017 done approach; 2,087, 5,961, a...

10.2106/jbjs.16.00494 article EN Journal of Bone and Joint Surgery 2017-05-17
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