A5023600052- Total Knee Arthroplasty Outcomes
- Lower Extremity Biomechanics and Pathologies
- Knee injuries and reconstruction techniques
- Sports injuries and prevention
- Orthopaedic implants and arthroplasty
- Osteoarthritis Treatment and Mechanisms
- Shoulder Injury and Treatment
- Tendon Structure and Treatment
- Hip disorders and treatments
- Orthopedic Infections and Treatments
- Foot and Ankle Surgery
- Bone fractures and treatments
- Orthopedic Surgery and Rehabilitation
- Hip and Femur Fractures
- History of Medicine Studies
- Genomics, phytochemicals, and oxidative stress
- Bone and Joint Diseases
- Inflammatory mediators and NSAID effects
- Paleopathology and ancient diseases
- Musculoskeletal synovial abnormalities and treatments
- Medical History and Innovations
- Cancer-related molecular mechanisms research
- Diabetic Foot Ulcer Assessment and Management
- Forensic Anthropology and Bioarchaeology Studies
- Pelvic and Acetabular Injuries
University of East Anglia
2016-2025
Norfolk and Norwich University Hospitals NHS Foundation Trust
2012-2025
Norwich Research Park
2015-2024
Norfolk and Norwich University Hospital
2010-2022
Norwich University
2001-2012
Lutheran Medical Center
2008
Addenbrooke's Hospital
2007
Norfolk Community Health and Care NHS Trust
2000
Hôpital Lyon Sud
1992-1995
Royal National Orthopaedic Hospital
1991-1994
The treatment of acute patellar dislocation in children is controversial. Some investigators have advocated early repair the medial structures, whereas others treated this injury nonoperatively. present report describes long-term subjective and functional results a randomized controlled trial nonoperative operative primary less than sixteen years age.The data were gathered prospectively on cohort seventy-four dislocations seventy-one patients (fifty-one girls twenty boys) younger age....
To profile the expression of all known members matrix metalloproteinase (MMP), ADAMTS, and tissue inhibitor metalloproteinases (TIMP) gene families in normal cartilage from patients with osteoarthritis (OA).Human was obtained femoral heads at joint replacement for OA or following fracture to neck. Total RNA purified, assayed using quantitative real-time polymerase chain reaction.Several above were regulated OA. Genes that showed increased MMP13, MMP28, ADAMTS16 (all P < 0.001), MMP9, MMP16,...
BackgroundLate-stage isolated medial knee osteoarthritis can be treated with total replacement (TKR) or partial (PKR). There is high variation in treatment choice and little robust evidence to guide selection. The Total Partial Knee Arthroplasty Trial (TOPKAT) therefore aims assess the clinical effectiveness cost-effectiveness of TKR versus PKR patients compartment knee, this represents an analysis main endpoints at 5 years.MethodsOur multicentre, pragmatic randomised controlled trial was...
To use an in vitro model of chondrogenesis to identify microRNAs (miRNAs) with a functional role cartilage homeostasis.The expression miRNAs was measured the ATDC5 cell using microarray and verified quantitative reverse transcription-polymerase chain reaction. MicroRNA localized by situ hybridization. Predicted miRNA target genes were validated 3'-untranslated region-Luc reporter plasmids containing either wild-type sequences or mutants sequence. Signaling through Smad pathway (CAGA)(12)...
Summary Replicative senescence occurs when normal somatic cells stop dividing. Senescent remain viable, but show alterations in phenotype, e.g. altered expression of matrix metalloproteinases ( MMPs ); these enzymes are known to be involved cartilage destruction. It is assumed that deplete their replicative potential during aging, and age a major risk factor for osteoarthritis (OA). Therefore, we hypothesized chondrocytes aging or diseased become senescent with associated phenotypic changes...
The radiographs of 206 knees from 174 consecutive patients were reported blinded regarding joint space narrowing. Minimum was measured using a millimeter ruler on weightbearing posteroanterior and skyline patellofemoral radiographs. Lateral solely in terms presence or absence arthritis. results showed objective narrowing to less than 3 mm the compartment 32.7% men 36.1% women older 60 years. This high prevalence disease has not been documented before. Arthritic changes occurred isolation...
Abstract Cartilage destruction in osteoarthritis (OA) is thought to be mediated by two main enzyme families; the matrix metalloproteinases (MMPs) are responsible for cartilage collagen breakdown, whereas enzymes from 'a disintegrin and metalloproteinase domain with thrombospondin motifs' (ADAMTS) family mediate aggrecan loss. Tissue inhibitors of (TIMPs) regulate activity these enzymes. Although OA might driven chondrocyte, low-grade synovitis reported patients all grades this disease. Our...
Background: The use of recombinant human bone morphogenetic protein-2 (rhBMP-2) to improve the healing open tibial shaft fractures has been focus two prospective clinical studies. objective current study was perform a subgroup analysis combined data from these Methods: Two prospective, randomized studies were conducted. A total 510 patients with receive control treatment (intramedullary nail fixation and routine soft-tissue management) or an absorbable collagen sponge impregnated one...
We performed two independent, randomised, controlled trials in order to assess the potential benefits of immediate weight-bearing mobilisation after rupture tendo Achillis. The first trial, on operatively-treated patients showed an improved functional outcome for mobilised fully surgical repair. Two cases re-rupture treatment group suggested that careful patient selection is required as need follow a structured rehabilitation regimen. second conservatively-treated patients, provided no...
We reviewed 195 knees in 167 patients at least 20 years after a rim-preserving meniscectomy. They were considered two groups: 102 had an intact anterior cruciate ligament (ACL), and 93 unrepaired rupture. More with ruptured ACL downgraded their sport activity by five The incidence of radiographic osteoarthritis was about 65% 27 ligament, 86% those followed up for over 30 years. In the ligament-deficient group 10% operations osteoarthritis, another 28% other operations, mainly further...
Tendon injury is common and debilitating, it associated with long-term pain ineffective healing. It estimated to afflict 25% of the adult population often a career-ending disease in athletes racehorses. high morbidity, pain, suffering for patient. Due low cellularity vascularity tendon tissue, once damage has occurred, repair process slow inefficient, resulting mechanically, structurally, functionally inferior tissue. Current treatment options focus on management, being palliative temporary...
MicroRNAs have been shown to function in cartilage development and homeostasis, as well progression of osteoarthritis. The objective the current study was identify microRNAs involved onset or early osteoarthritis characterise their chondrocytes. MicroRNA expression mouse knee joints post-DMM surgery measured over 7 days. Expression miR-29b-3p increased at day 1 regulated opposite direction its potential targets. In a model injury end-stage human OA cartilage, miR-29 family also regulated....