A5102743898- Total Knee Arthroplasty Outcomes
- Orthopaedic implants and arthroplasty
- Orthopedic Infections and Treatments
- Hip disorders and treatments
- Intensive Care Unit Cognitive Disorders
- Anesthesia and Neurotoxicity Research
- Hip and Femur Fractures
- Knee injuries and reconstruction techniques
- Cardiac, Anesthesia and Surgical Outcomes
- Anesthesia and Sedative Agents
- Antibiotic Resistance in Bacteria
- Antibiotics Pharmacokinetics and Efficacy
- Neonatal and Maternal Infections
- Nursing Roles and Practices
- Antibiotic Use and Resistance
- Diet and metabolism studies
- Venous Thromboembolism Diagnosis and Management
- Shoulder Injury and Treatment
- Anesthesia and Pain Management
- Alcoholism and Thiamine Deficiency
- Bacterial Infections and Vaccines
- Pneumonia and Respiratory Infections
- Patient Satisfaction in Healthcare
- Musculoskeletal Disorders and Rehabilitation
- Trauma, Hemostasis, Coagulopathy, Resuscitation
Global Antibiotic Research & Development Partnership
2022-2024
Musgrave Park Hospital
2012-2023
Belfast Health and Social Care Trust
2016-2023
Lancashire Teaching Hospitals NHS Foundation Trust
2023
Royal Victoria Hospital
2022
University of Oxford
2019
Pfizer (United States)
2019
Molecular Medicine Ireland
2013
Minimally invasive total hip arthroplasty has stirred substantial controversy with regard to whether it provides superior outcomes compared performed through longer incisions. The orthopaedic literature is deficient in well-designed scientific studies support the clinical superiority of this approach. objective study was compare results a single mini-incision approach those standard-incision early postoperative period.Two hundred and nineteen patients (219 hips) admitted for unilateral...
BackgroundLate-stage isolated medial knee osteoarthritis can be treated with total replacement (TKR) or partial (PKR). There is high variation in treatment choice and little robust evidence to guide selection. The Total Partial Knee Arthroplasty Trial (TOPKAT) therefore aims assess the clinical effectiveness cost-effectiveness of TKR versus PKR patients compartment knee, this represents an analysis main endpoints at 5 years.MethodsOur multicentre, pragmatic randomised controlled trial was...
Abstract Objectives To investigate pharmacokinetics (PK) and safety (primary objectives) efficacy (secondary objective) of the investigational monobactam/β-lactamase inhibitor combination aztreonam/avibactam in patients with complicated intra-abdominal infection (cIAI). Methods This Phase 2a open-label, multicentre study (NCT02655419; EudraCT 2015-002726-39) enrolled adults cIAI into sequential cohorts for 5–14 days treatment. Cohort 1 received an loading dose 500/137 mg (30 min infusion),...
Background Despite significant global progress in reducing neonatal mortality, bacterial sepsis remains a major cause of deaths. Klebsiella pneumoniae ( K . ) is the leading pathogen globally underlying cases and frequently resistant to antibiotic treatment regimens recommended by World Health Organization (WHO), including first-line therapy with ampicillin gentamicin, second-line amikacin ceftazidime, meropenem. Maternal vaccination prevent infection could reduce burden low- middle-income...
The Cementless Oxford Unicompartmental Knee Replacement (OUKR) was developed to address problems related cementation, and has been demonstrated in a randomised study have similar clinical outcomes with fewer radiolucencies than observed the cemented device. However, before its widespread use it is necessary clarify contraindications assess complications. This requires larger any previously published. We present prospective multicentre series of 1000 cementless OUKRs 881 patients at minimum...
To test the hypothesis that APOE ε4 status and cerebrospinal fluid (CSF) Aβ42, T-tau P-tau would independently predict risk of postoperative delirium.Delirium following surgery is common associated with adverse outcomes. Age cognitive impairment are consistent factors for delirium.This observational cohort study recruited 282 participants aged 65 years or older, without a diagnosis dementia, admitted primary elective hip knee arthroplasty. Cognitive tests were undertaken preoperatively,...
Lower limb length differences of up to 10mm exist in 60% - 95% the population.There are usually no symptoms or functional effects. Following Total Hip Arthroplasty (THA), satisfactory clinical results can be spoiled by dissatisfaction due a change leg length. Although may modest comparison normal variation, patient perceive this as discrepancy. To study average threshold for perception, artificial discrepancies 5 mm 25 were created 30 young healthy adults using calibrated wooden blocks....
A common perception among clinicians and patients is that recovery similar following total hip arthroplasty (THA) knee (TKA). Improvement in the outcomes of 337 THAs 256 TKAs implanted by same surgeon between April 2003 November 2005 were compared. was measured using changes Oxford scores preoperatively, at first follow-up, 1 year postoperatively for each patient. Improvements preoperative review follow-up 1-year postoperative significantly greater THA compared to TKA patients. not different...
Background: Minimally invasive total hip arthroplasty has stirred substantial controversy with regard to whether it provides superior outcomes compared performed through longer incisions. The orthopaedic literature is deficient in well-designed scientific studies support the clinical superiority of this approach. objective study was compare results a single mini-incision approach those standard-incision early postoperative period. Methods: Two hundred and nineteen patients (219 hips)...
Our aim was to examine the clinical and radiographic outcomes in 257 consecutive Oxford unicompartmental knee arthroplasties (OUKAs) (238 patients), five years post-operatively.A retrospective evaluation undertaken of patients treated between April 2008 October 2010 a regional centre by two non-designing surgeons with no previous experience UKAs. The Knee Scores (OKSs) were recorded fluoroscopically aligned radiographs assessed post-operatively at one years.The median age 238 65.0...
The objective of this study was to determine the prevalence radiolucent lines (RLLs) around femoral component in a cohort patients who underwent well-functioning cementless total hip arthroplasty (THA).A unrevised Corail (DePuy Synthes, Raynham, MA) components (n = 636) were analyzed at median follow-up 6.0 years (interquartile range: 5.2-6.8) with Oxford Hip Score (OHS) and radiographs. Two independent observers assessed radiographs for presence RLLs.The overall RLLs zone 7 13% (83/636)....
Objective: To compare outcomes from hip arthroplasty between a surgical unit with rapid discharge policy and two comparison units to test the hypothesis that centre has are not inferior sites. Design: Prospective cohort study. Subjects: Consecutive consenting patients receiving primary during 12 months beginning July 2006 in three UK National Health Service units. One shortened postoperative stay median days; one was new treatment of five third traditional six days (N = 316, 119, 87,...
To describe patients' experience of accelerated discharge after hip arthroplasty in order to test the acceptability patients economically driven shortening post-operative stay.Patients (n = 35) who had received primary total replacement up 12 weeks previously were recruited from two UK orthopaedic units, one which has pioneered short stay (3-4 days), and another retains a traditional regimen 6-7 days. Patients interviewed about their care, focusing particularly on views related length with...
delirium following surgery is common and associated with negative outcomes. Preoperative cognitive impairment has been shown to be a risk factor for post-operative delirium. Often the tests used are cumbersome. This study hypothesis that quantification of brain vulnerability, using Apolipoprotein E (ApoE) status neuropsychological tests, both traditional more easily administered, can quantify elective primary arthroplasty surgery. this observational cohort recruited participants aged 65...
Ceramic-on-metal (CoM) is a relatively new bearing combination for total hip arthroplasty (THA) with few reported outcomes. A of 287 CoM THAs were carried out in 271 patients (mean age 55.6 years (20 to 77), 150 female patients, 137 male) under the care single surgeon between October 2007 and 2009. With issues surrounding metal-on-metal bearings decision was taken review these March November 2011, at mean follow-up 34 months (23 45) record pain, outcome scores, radiological analysis blood...
Abstract Delirium is a marker of brain vulnerability, associated with increasing age, pre-existing cognitive impairment and, recently, cerebrospinal fluid (CSF) biomarkers Alzheimer’s disease. This nested case-control study used targeted quantitative metabolomic methodology to profile the preoperative CSF patients (n = 54) who developed delirium following arthroplasty 28) and those did not 26). The aim was identify novel markers delirium, assess potential correlations clinical data....
In an initial randomised controlled trial (RCT) we segregated 180 patients to one of two knee positions following total replacement (TKR): six hours flexion using either a jig or extension. Outcome measures included post-operative blood loss, fall in haemoglobin, transfusion requirements, range movement, limb swelling and functional scores. A second RCT consisted 420 TKR three positions: for post-operatively, Positioning the immediately after surgery significantly reduced loss (p = 0.002)....