A5056938637- Global Cancer Incidence and Screening
- Pelvic floor disorders treatments
- Radiomics and Machine Learning in Medical Imaging
- Lipoproteins and Cardiovascular Health
- Cancer Risks and Factors
- Urinary Bladder and Prostate Research
- Retinal and Macular Surgery
- Breast Cancer Treatment Studies
- Intraocular Surgery and Lenses
- Glaucoma and retinal disorders
- Health Systems, Economic Evaluations, Quality of Life
- Medical Imaging Techniques and Applications
- Sex and Gender in Healthcare
- Obesity and Health Practices
- Prostate Cancer Diagnosis and Treatment
- Meta-analysis and systematic reviews
- Colorectal Cancer Screening and Detection
- Urinary Tract Infections Management
- Delphi Technique in Research
- Kidney Stones and Urolithiasis Treatments
- Obesity, Physical Activity, Diet
- Bladder and Urothelial Cancer Treatments
- Acute Myocardial Infarction Research
- Reliability and Agreement in Measurement
- Healthcare Systems and Public Health
Kwame Nkrumah University of Science and Technology
2023
University of Aberdeen
2009-2019
University of Glasgow
2014-2019
Assistance Publique – Hôpitaux de Paris
2013
There is great interest in widening the use of high-sensitivity cardiac troponins for population cardiovascular disease (CVD) and heart failure screening. However, it not clear whether troponin T (cTnT) I (cTnI) are equivalent measures risk this setting. We aimed to compare contrast (1) association cTnT cTnI with CVD non-CVD outcomes, (2) their determinants a genome-wide study.High-sensitivity were measured serum from 19 501 individuals Generation Scotland Scottish Family Health Study....
BackgroundLate-stage isolated medial knee osteoarthritis can be treated with total replacement (TKR) or partial (PKR). There is high variation in treatment choice and little robust evidence to guide selection. The Total Partial Knee Arthroplasty Trial (TOPKAT) therefore aims assess the clinical effectiveness cost-effectiveness of TKR versus PKR patients compartment knee, this represents an analysis main endpoints at 5 years.MethodsOur multicentre, pragmatic randomised controlled trial was...
Purpose.: To determine whether internal limiting membrane (ILM) peeling is effective and cost compared with no in patients idiopathic stage 2 or 3 full-thickness maculay hole (FTMH). Methods.: This was a pragmatic multicenter randomized controlled trial. Eligible participants from nine centers were to ILM (1:1 ratio) addition phacovitrectomy, including detachment removal of the posterior hyaloid gas tamponade. The primary outcome distance visual acuity (VA) at 6 months after surgery....
Objective To assess the clinical effectiveness and cost-effectiveness of photodynamic diagnosis (PDD) compared with white light cystoscopy (WLC), urine biomarkers [fluorescence in situ hybridisation (FISH), ImmunoCyt, NMP22] cytology for detection follow-up bladder cancer. Data sources Major electronic databases including MEDLINE, MEDLINE In-Process, EMBASE, BIOSIS, Science Citation Index, Health Management Information Consortium Cochrane Controlled Trials Register were searched until April...
Few data compare cardiac troponin T (cTnT) and I (cTnI) in a general population. We sought to evaluate the distribution association between cTnT, cTnI, cardiovascular risk factors large population cohort.High-sensitivity cTnT cTnI were measured serum from 19501 individuals Generation Scotland Scottish Family Health Study. Associations with compared using age- sex-adjusted regression. Observed sex-stratified 99th centiles for (men, 15.5 ng/L; women, 9.0 ng/L) 34.2 15.6 used clinical...
Abstract Aim Rectal cancer patients undergoing neoadjuvant chemoradiotherapy (NACRT) experience physical deterioration and reductions in their quality of life. This feasibility study assessed prehabilitation (a walking intervention) before, during after NACRT to inform a definitive multi‐centred randomized clinical trial (REx trial). Methods Patients planned for followed by potentially curative surgery were approached (August 2014–March 2016) ( www.isrctn.com ; 62859294). Prior NACRT,...
The Health Technology Assessment (HTA) programme, part of the National Institute for Research (NIHR), was set up in 1993.It produces high-quality research information on effectiveness, costs and broader impact health technologies those who use, manage provide care NHS.'Health technologies' are broadly defined as all interventions used to promote health, prevent treat disease, improve rehabilitation long-term care.The findings from HTA programme directly influence decision-making bodies such...
Background: Both statins and proprotein convertase subtilisin/kexin type 9 (PCSK9) inhibitors lower blood low-density lipoprotein cholesterol levels to reduce risk of cardiovascular events. To assess potential differences between metabolic effects these 2 lipid-lowering therapies, we performed detailed lipid metabolite profiling a large randomized statin trial compared the results with genetic inhibition PCSK9, acting as naturally occurring trial. Methods: Two hundred twenty-eight...
Ureteric colic, the term used to describe pain felt when a stone passes down ureter from kidney bladder, is frequent reason for people seek emergency health care. Treatment with muscle-relaxant drugs tamsulosin hydrochloride (Petyme, TEVA UK Ltd) and nifedipine (Coracten(®), UCB Pharma as medical expulsive therapy (MET) increasingly being improve likelihood of spontaneous passage lessen need interventional procedures. However, there remains considerable uncertainty around effectiveness these...
<b>Objectives</b> To determine the long term clinical effectiveness of laparoscopic fundoplication as an alternative to drug treatment for chronic gastro-oesophageal reflux disease (GORD). <b>Design</b> Five year follow-up multicentre, pragmatic randomised trial (with parallel non-randomised preference groups). <b>Setting</b> Initial recruitment in 21 UK hospitals. <b>Participants</b> Responders annual questionnaires among 810 original participants. At entry, all had GORD >12 months....
We investigated the association between quantified metabolite, lipid and lipoprotein measures incident heart failure hospitalisation (HFH) in elderly, examined whether circulating metabolic improve HFH prediction.Overall, 80 from PROspective Study of Pravastatin Elderly at Risk (PROSPER) trial were measured by proton nuclear magnetic resonance spectroscopy (n = 5341; 182 events during 2.7-year follow-up). repeated work FINRISK 1997 7330; 133 5-year In PROSPER, concentrations 13 found to be...
Despite promising evidence that laparoscopic fundoplication provides better short-term relief of gastro-oesophageal reflux disease (GORD) than continued medical management, uncertainty remains about whether benefits are sustained and outweigh risks.To evaluate the long-term clinical effectiveness, cost-effectiveness safety surgery among people with GORD requiring medication suitable for both surgical management.Five-year follow-up a randomised trial (with parallel non-randomised preference...