A5040809303- Electroconvulsive Therapy Studies
- Behavioral Health and Interventions
- Neural and Behavioral Psychology Studies
- Treatment of Major Depression
- Retinal Diseases and Treatments
- Traumatic Brain Injury Research
- Behavioral and Psychological Studies
- Glaucoma and retinal disorders
- Musculoskeletal pain and rehabilitation
- Decision-Making and Behavioral Economics
- Transcranial Magnetic Stimulation Studies
- Meta-analysis and systematic reviews
- Anxiety, Depression, Psychometrics, Treatment, Cognitive Processes
- Substance Abuse Treatment and Outcomes
- Neurotransmitter Receptor Influence on Behavior
- Ophthalmology and Visual Impairment Studies
- Anesthesia and Sedative Agents
- Gambling Behavior and Treatments
- Sport Psychology and Performance
- Child and Animal Learning Development
- Balance, Gait, and Falls Prevention
- Domain Adaptation and Few-Shot Learning
- Face Recognition and Perception
- Ethics in medical practice
- Cognitive Abilities and Testing
University of Aberdeen
2012-2022
Royal Cornhill Hospital
2017
NHS Grampian
2017
National Health Service Scotland
2014
University of Liverpool
2008-2013
University of Nottingham
2005-2011
Keele University
2005
University of Glasgow
2005
BackgroundLate-stage isolated medial knee osteoarthritis can be treated with total replacement (TKR) or partial (PKR). There is high variation in treatment choice and little robust evidence to guide selection. The Total Partial Knee Arthroplasty Trial (TOPKAT) therefore aims assess the clinical effectiveness cost-effectiveness of TKR versus PKR patients compartment knee, this represents an analysis main endpoints at 5 years.MethodsOur multicentre, pragmatic randomised controlled trial was...
Aims We investigated reciprocal prospective relationships between multiple behavioural impulsivity tasks (assessing delay discounting, risk-taking and disinhibition) alcohol involvement (consumption, drunkenness problems) among adolescents. hypothesized that performance on the would predict subsequent involvement, lead to increases in over time. Design Cross-lagged design which were assessed five times 2 years (once every 6 months, average). Setting Classrooms secondary schools North West...
To determine whether primary trabeculectomy or medical treatment produces better outcomes in term of quality life, clinical effectiveness, and safety patients presenting with advanced glaucoma.Pragmatic multicentre randomised controlled trial.27 secondary care glaucoma departments the UK.453 adults newly diagnosed open angle at least one eye (Hodapp classification) between 3 June 2014 31 May 2017.Mitomycin C augmented (n=227) escalating management intraocular pressure reducing drops (n=226)...
Several recent studies suggest that alcohol-related cues elicit automatic approach tendencies in heavy drinkers. A variety of tasks have been used to demonstrate these effects, including Relevant Stimulus-Response Compatibility (R-SRC) and variants Simon tasks. Previous work with normative stimuli suggests the R-SRC task may be more sensitive than because activation depend on encoding as alcohol-related, which occurs but not Our aim was directly compare for first time context alcohol use. We...
Background Electroconvulsive therapy (ECT) is an effective treatment for depression but the extent and persistence of cognitive side-effects remain uncertain. It has been reported that there little evidence impairments last longer than up to 15 days post-ECT. However, relatively few studies have followed patients even as long 1 month Here we report results from a brief battery given prior ECT repeated five times 6 months Method In retrospective case-note study routinely collected clinical...
BackgroundKetamine has recently become an agent of interest as acute treatment for severe depression and the anaesthetic electroconvulsive therapy (ECT). Subanaesthetic doses result in reduction severity while evidence is equivocal this antidepressant effect with or adjuvant doses. Recent systematic reviews call high-quality from further randomised controlled trials (RCTs).AimsTo establish if ketamine ECT results fewer treatments, improvements ratings less memory impairment than standard...
Background Presentation with advanced glaucoma is the major risk factor for lifetime blindness. Effective intervention at diagnosis expected to minimise of further visual loss in this group patients. Aim To compare clinical and cost-effectiveness primary medical management compared surgery people presenting open-angle (OAG). Methods Design : A prospective, pragmatic multicentre randomised controlled trial (RCT). Setting Twenty-seven UK hospital eye services. Participants Four hundred forty...
ABSTRACT Aims Theoretical models suggest that attentional bias for alcohol‐related cues develops because signal the availability of alcohol, and expectancy elicited by alcohol is responsible maintenance among regular drinkers. We investigated moderating role on cues. Design Within‐subjects experimental design. Setting Psychology laboratories. Participants Adult social drinkers ( n = 58). Measurements On a trial‐by‐trial basis, participants were informed probability (100%, 50%, 0%) they would...
To assess mild head injury effects in adolescent soccer players, neuropsychological performance across school team rugby players and noncontact sport was assessed a quasi-experimental cross-sectional design. One hundred eighty-five males were tested (ages 13-16; response rate 55%) 86 contributed data to the analyses after exclusion for recent concussion overlapping sports participation. Soccer showed lower premorbid intellectual functioning, but neither nor decrement compared with players....
Previous research has claimed neuropsychological impairment occurs as a result of professional and amateur football play, and, specifically, heading. However, much this exhibits substantial methodological problems. By investigating less committed level footballers, the current study sought to gain some insight into developmental history any consequences play. University football, rugby noncontact sports players were compared on range biographical test variables. While playing their chosen...
Alcohol intoxication is known to influence attentional biases for alcohol-related cues and alcohol-seeking behaviour. It unknown if heavier drinkers are more or less sensitive these effects of alcohol, whether the alcohol on bias associated with subsequent In present study, 55 social were administered either 0.4 g/kg placebo in a repeated measures, double-blind experimental design. Participants completed visual probe task eye movement monitoring (to measure bias) bogus taste test...
The importance of unconscious autonomic activity versus knowledge in influencing behaviour on the Iowa Gambling Task (IGT) has been subject debate. tasks developers, Bechara and colleagues, have claimed that IGT is influenced by somatic this precedes emergence about task contingencies sufficient to guide behaviour. Since then other emerges much earlier task. However, it yet be established whether which differentiates between advantageous disadvantageous choices found before point. This study...
Footballers run the risk of incurring mild head injury from a variety sources, including intentional use to play ball, known as heading. This paper presents preliminary exploratory analysis data collected examine whether cumulative incidence injury, or heading frequency, are related neuropsychological functioning in male adolescent footballers. In quasi-experimental cross-sectional design, test scores school team footballers were compared with those similarly aged rugby players and...
Male players from football and rugby clubs sportsmen a variety of noncontact sports at UK university were compared on biographical neuropsychological test measures. A data analysis paradigm was developed employed to control the inflation Type 1 error rate due multiple hypotheses testing. Rugby sustained most head injuries in their chosen sport, but tests attention, memory, executive function provided no evidence performance impairment attributable number or football, rugby, sport groups....
Abstract Background Data collection consumes a large proportion of clinical trial resources. Each data item requires time and effort for collection, processing quality control procedures. In general, more equals heavier burden staff participants. It is also likely to increase costs. Knowing the types being collected, in what proportion, will be helpful ensure that limited resources participant goodwill are used wisely. Aim The aim this study categorise collected across broad range trials...
Background Patients diagnosed with advanced primary open-angle glaucoma are at a high risk of lifetime blindness. Uncertainty exists about whether medical management (glaucoma eye drops) or surgical treatment (augmented trabeculectomy) provide the best and safest patient outcomes. Objectives To compare in patients presenting disease terms health-related quality life, clinical effectiveness, safety cost-effectiveness. Design This was two-arm, parallel, multicentre, pragmatic randomised...
The claim that recollection and familiarity based memory processes have distinct retrieval mechanisms is partly on the observation masked repetition semantic priming influence estimates of derived from know responses but no effect remember responses. Close inspection experiments which this reveal size to be small, potentially result a type-2 error, and/or inflated due participants not having opportunity report guesses. This paper re-evaluates these claims by attempting partial replication...
This study aimed to explore the relationship of Montgomery-Åsberg Depression Rating Scale (MADRS) symptom subtypes with response electroconvulsive therapy (ECT) and subsequent ECT treatment within 12 months.A consecutive sample 414 patients depression receiving in North East Scotland was assessed by retrospective chart review. Response rate defined as greater than or equal 50% decrease pretreatment total MADRS score a posttreatment less 10. Principal component analyses were conducted on...
Despite extensive clinical concern about rates of obesity in patients with schizophrenia, there is little evidence the extent this problem at a population level.To estimate levels national sample by comparing schizophrenia matched controls.We calculated for each patient from Primary Care Clinical Informatics Unit database (n=4658) age, gender and neighbourhood demonstrated significant increased hazard group using Cox regression analysis, odds ratio (OR) 1.94 (95% CI 1.81-2.10) (under...
To assess the relationship between electrical stimulation administered to patients undergoing bilateral electroconvulsive therapy (ECT) and subsequent measures of cognitive function depression severity.Stimulus dose titrated receiving ECT were assessed with Cambridge Neuropsychological Test Automated Battery (CANTAB) Spatial Recognition Memory test Montgomery Asberg Depression Rating Scale (MADRS) at baseline, after 4 treatments on course completion. Changes in CANTAB MADRS scores relation...
Abstract A number of studies have suggested that football heading is associated with neuropsychological impairment. However, analyses indicating such a relationship employed footballers' subjective estimations rather than objective measures their frequency. This despite frequency estimation research suggesting would be inaccurate. In two examining the between estimates and observed frequency, were found to inaccurate, but positively related actual there differences in estimate accuracy...