Emma Ogburn
A5034507700- COVID-19 Clinical Research Studies
- Health Systems, Economic Evaluations, Quality of Life
- Blood Pressure and Hypertension Studies
- Long-Term Effects of COVID-19
- HER2/EGFR in Cancer Research
- Breast Cancer Treatment Studies
- Ethics in Clinical Research
- Chronic Kidney Disease and Diabetes
- Sleep and related disorders
- COVID-19 and Mental Health
- Heart Rate Variability and Autonomic Control
- Cardiac Health and Mental Health
- Chronic Disease Management Strategies
- Advanced Breast Cancer Therapies
- Sleep and Wakefulness Research
- Noise Effects and Management
- Child Nutrition and Feeding Issues
- SARS-CoV-2 detection and testing
- Statistical Methods in Clinical Trials
- Hearing Loss and Rehabilitation
- Hearing, Cochlea, Tinnitus, Genetics
- SARS-CoV-2 and COVID-19 Research
- Renal Diseases and Glomerulopathies
- Intensive Care Unit Cognitive Disorders
- Sepsis Diagnosis and Treatment
University of Oxford
2017-2024
Nuffield Health
2018-2023
Royal College of General Practitioners
2021
Imperial College London
2021
The University of Queensland
2021
UK Research and Innovation
2021
National Institute for Health Research
2021
University of Warwick
2011-2016
Coventry (United Kingdom)
2012
<h2>Summary</h2><h3>Background</h3> Studies evaluating titration of antihypertensive medication using self-monitoring give contradictory findings and the precise place telemonitoring over alone is unclear. The TASMINH4 trial aimed to assess efficacy self-monitored blood pressure, with or without telemonitoring, for in primary care, compared usual care. <h3>Methods</h3> This study was a parallel randomised controlled done 142 general practices UK, included hypertensive patients older than 35...
<h2>Summary</h2><h3>Background</h3> Azithromycin, an antibiotic with potential antiviral and anti-inflammatory properties, has been used to treat COVID-19, but evidence from community randomised trials is lacking. We aimed assess the effectiveness of azithromycin suspected COVID-19 among people in who had increased risk complications. <h3>Methods</h3> In this UK-based, primary care, open-label, multi-arm, adaptive platform trial interventions against at adverse clinical course (PRINCIPLE),...
Abstract Objective The HOME BP (Home and Online Management Evaluation of Blood Pressure) trial aimed to test a digital intervention for hypertension management in primary care by combining self-monitoring blood pressure with guided self-management. Design Unmasked randomised controlled automated ascertainment endpoint. Setting 76 general practices the United Kingdom. Participants 622 people treated but poorly (>140/90 mm Hg) access internet. Interventions were using minimisation algorithm...
Background: The safety, effectiveness and cost-effectiveness of molnupiravir, an oral antiviral medication for SARS-CoV-2, in patients the community who are multiply-vaccinated at increased risk morbidity mortality from COVID-19, has not been established. We aimed to determine whether molnupiravir added usual care reduced hospital admissions/deaths among people higher here report our preliminary analyses.Methods: Participants this UK multicentre, open-label, adaptive, multi-arm, platform,...
Insomnia is prevalent and distressing but access to the first-line treatment, cognitive behavioural therapy (CBT), extremely limited. We aimed assess clinical cost-effectiveness of sleep restriction therapy, a key component CBT, which has potential be widely implemented.We did pragmatic, superiority, open-label, randomised controlled trial versus hygiene. Adults with insomnia disorder were recruited from 35 general practices across England randomly assigned (1:1) using web-based...
Chronic kidney disease (CKD) is a largely asymptomatic condition of diminished renal function, which may not be detected until advanced stages without screening.To establish undiagnosed and overall CKD prevalence using cross-sectional analysis.Longitudinal cohort study in UK primary care.Participants aged ≥60 years were invited to attend screening visits determine whether they had reduced function (estimated glomerular filtration rate [eGFR] <60 ml/min/1.73 m2 or albumin:creatinine ratio ≥3...
Background Colchicine has been proposed as a COVID-19 treatment. Aim To determine whether colchicine reduces time to recovery and COVID-19-related admissions hospital and/or deaths among people in the community. Design setting Prospective, multicentre, open-label, multi-arm, randomised, controlled, adaptive platform trial (PRINCIPLE). Method Adults aged ≥65 years or ≥18 with comorbidities shortness of breath, unwell for ≤14 days suspected community, were randomised usual care, care plus (500...
Introduction There is an urgent need to determine the safety, effectiveness and cost-effectiveness of novel antiviral treatments for COVID-19 in vaccinated patients community at increased risk morbidity mortality from COVID-19. Methods analysis PANORAMIC a UK-wide, open-label, prospective, adaptive, multiarm platform, randomised clinical trial that evaluates community. A master protocol governs addition new as they become available, introduction cessation existing interventions via interim...
Abstract BACKGROUND Inhaled budesonide has shown efficacy for treating COVID-19 in the community but not yet been tested effectiveness trials. METHODS We performed a multicenter, open-label, multi-arm, adaptive platform randomized controlled trial involving people aged ≥65 years, or ≥50 years with comorbidities, and unwell ≤14 days suspected (PRINCIPLE). Participants were to usual care, care plus inhaled (800µg twice daily 14 days), other interventions. The co-primary endpoints are time...
There is an urgent need to idenfy treatments for COVID-19 that reduce illness duration and hospital admission in those at higher risk of a longer course complications.The Platform Randomised trial INterventions against In older peoPLE open-label, multiarm, prospective, adaptive platform, randomised clinical evaluate potential the community. A master protocol governs addition new interventions as they become available, well inclusion cessation existing intervention arms via frequent interim...
Background Insomnia is a prevalent and distressing sleep disorder. Multicomponent cognitive–behavioural therapy the recommended first-line treatment, but access remains extremely limited, particularly in primary care where insomnia managed. One principal component of behavioural treatment called restriction therapy, which could potentially be delivered as brief single-component intervention by generalists care. Objectives The objective Health-professional Administered Brief Therapy trial was...
We report cardiac events in the Persephone trial which compares 6–12 months of adjuvant trastuzumab women with confirmed HER2-positive, early-stage breast cancer. Clinical were defined as any following: symptoms and/or signs congestive heart failure (CHF) and new or altered CHF medication. In addition, left ventricular ejection fraction (LVEF) was measured at baseline then 3 monthly for 12 months. A total 2500 patients, aged 22–82, included: 1251 randomised to 1249 6 treatment. 93%...
Chronic kidney disease (CKD) is diagnosed using the estimated glomerular filtration rate (eGFR) and urinary albumin:creatinine ratio (ACR). The eGFR calculated from serum creatinine levels Modification of Diet in Renal Disease (MDRD) or Kidney Epidemiology Collaboration (CKD-EPI) equations.To compare performance one versus two eGFR/ACR measurements, impact equation choice, on CKD diagnosis classification.Cohort study primary care Thames Valley region UK.Data were 485 participants aged >60...
Self-monitoring of hypertension is associated with lower systolic blood pressure (SBP). However, evidence for the use self-monitoring to titrate antihypertensive medication by physicians equivocal. Furthermore, there some efficacy telemonitoring in management but it not clear what this adds over and above self-monitoring. This trial aims evaluate whether GP led titration using results SBP compared usual care anything alone. will be a pragmatic primary based, unblinded, randomised controlled...
Objectives To establish the prevalence of multimorbidity in people with chronic kidney disease (CKD) stages 1–5 and transiently impaired renal function identify factors associated multimorbidity. Design setting Prospective cohort study UK primary care. Participants 861 participants aged 60 older decreased whom, 584 (65.8%) had CKD 277 (32.2%) did not have CKD. Interventions underwent medical history clinical assessment, blood urine sampling. Primary secondary outcome measures Multimorbidity...
Abstract Background The COVID-19 pandemic has presented unique challenges for rapidly designing, initiating, and delivering therapeutic clinical trials. PRINCIPLE (Platform Randomised Trial of Treatments in the Community Epidemic Pandemic Illnesses) is UK national platform investigating repurposed therapies treatment older people community at high risk complications. Standard methods patient recruitment were failing to meet required pace scale enrolment. This paper describes development...
Abstract Background Data collection consumes a large proportion of clinical trial resources. Each data item requires time and effort for collection, processing quality control procedures. In general, more equals heavier burden staff participants. It is also likely to increase costs. Knowing the types being collected, in what proportion, will be helpful ensure that limited resources participant goodwill are used wisely. Aim The aim this study categorise collected across broad range trials...
Introduction Recent evidence suggests that larger blood pressure reductions and multiple antihypertensive drugs may be harmful in older people, particularly frail individuals with polypharmacy multimorbidity. However, there is a lack of to support deprescribing antihypertensives, which limits the practice medication reduction routine clinical care. The aim this trial examine whether possible patients without significant changes control at follow-up. Methods analysis This will use primary...
Insomnia is a prevalent sleep disorder that negatively affects quality of life. Multicomponent cognitive-behavioural therapy (CBT) the recommended treatment but access remains limited, particularly in primary care. Sleep restriction (SRT) one principal active components CBT and could be delivered by generalist staff The aim this randomised controlled trial to establish whether nurse-delivered SRT for insomnia clinically cost-effective compared with hygiene advice.
Abstract Objectives Colchicine has been proposed as a COVID-19 treatment, but its effect on time to recovery is unknown. We aimed determine whether colchicine effective at reducing and related hospitalisations/deaths among people in the community. Design Prospective, multicentre, open-label, multi-arm, adaptive Platform Randomised Trial of Treatments Community for Epidemic Pandemic Illnesses (PRINCIPLE). Setting National trial run remotely from central site multiple primary care centres...
Evidence for the effect of favipiravir treatment acute COVID-19 on recovery, hospital admissions and longer-term outcomes in community settings is limited.