A5030752596- Urinary Tract Infections Management
- Pelvic floor disorders treatments
- Antibiotic Use and Resistance
- Urinary Bladder and Prostate Research
- Streptococcal Infections and Treatments
- Patient Satisfaction in Healthcare
- Pediatric Urology and Nephrology Studies
- COVID-19 Clinical Research Studies
- Liver Disease and Transplantation
- Liver Disease Diagnosis and Treatment
- Health Systems, Economic Evaluations, Quality of Life
- Bacterial Identification and Susceptibility Testing
- Sepsis Diagnosis and Treatment
- Emergency and Acute Care Studies
- Atrial Fibrillation Management and Outcomes
- Primary Care and Health Outcomes
- Innovations in Medical Education
- Iron Metabolism and Disorders
- Pneumonia and Respiratory Infections
- SARS-CoV-2 and COVID-19 Research
- Microscopic Colitis
- Healthcare Systems and Technology
- Chronic Disease Management Strategies
- Particle physics theoretical and experimental studies
- Colorectal Cancer Screening and Detection
Cardiff University
2015-2025
Swansea University
2024
Cochrane
2013
Foundry (United Kingdom)
2012
National Student Clearinghouse Research Center
2012
West Midlands Deanery
2012
Jinnah Postgraduate Medical Center
1984
The communication of risk is an important and often difficult aspect clinical practice.This review aims to provide practising clinicians with a comprehensive up date overview current evidence in this developing area.
Risk communication is an essential part of shared decision making and evidence-based patient choice.1 Discussing a patient's cardiovascular risk, their risk reduction from taking statin, the risks benefits colorectal screening, or truth behind tabloids latest claim that vegetable X reduces cancer Y by 50%, are all examples everyday general practice consultations involve about information. Effective important for doctor patient. Mrs Jones more likely to choose take her statin if she...
Urinary tract infections (UTI) are an important cause of morbidity and antibiotic use in older adults but there little data describing disease burden primary care. The aim this study was to estimate the incidence clinically diagnosed UTI examine associated empirical prescribing. We conducted a retrospective observational using linked health records from almost one million patients aged ≥65 years old, registered with 393 care practices England. estimated between March 2004 April 2014, used...
The cost-effectiveness of molnupiravir, an oral antiviral for early treatment SARS-CoV-2, has not been established in vaccinated populations.
Abstract Background Bloodstream infections (BSIs) are common, life-threatening infections. However, it remains unclear whether deaths following BSIs primarily from uncontrolled infection or underlying comorbidities. We aimed to determine the overall mortality, infection-attributable and causes of death for four leading BSI pathogens. Methods This retrospective cohort study was conducted within Secure Anonymized Information Linkage Databank, containing anonymized population-scale electronic...
Back pain is one of the most common causes for disability in working population. Some risk factors back are well known, however little known about uniquely associated with acute or chronic pain. This study aimed to elucidate patterns performed secondary analysis data from Welsh Health Survey 2012, a nationwide cross-sectional survey. A multivariable was carried out found be significantly and We that increased BMI (aOR 1.20, 95% Cis 1.08, 1.33; > 30), mental health score below average 1.59,...
Abstract Background Liver disease is within the top five causes of premature death in adults. Deaths caused by complications cirrhosis continue to rise, whilst deaths related other non-liver areas are declining. Portal hypertension primary sequelae and associated with development variceal haemorrhage, ascites, hepatic encephalopathy infection, collectively termed decompensation, which leads hospitalisation mortality. It remains uncertain whether administering a non-selective beta-blocker...
An NHS-funded sore throat test and treat (STTT) service was introduced in selected community pharmacies Wales. Service users were screened using FeverPAIN/Centor scores, offered rapid antigen detection testing (RADT) to detect group A Streptococcus if appropriate, supplied with antibiotics (by the pharmacist) indicated. Following an initial evaluation, rolled out nationally.
Abstract Iron deficiency is associated with a substantial burden of morbidity. However, supplementation iron has been linked to increased rates serious infection in randomised trials children sub-Saharan Africa. Randomised other settings have inconclusive and it unknown if changes levels biomarkers are sepsis these settings. We used genetic variants as instrumental variables Mendelian randomisation (MR) analysis test the hypothesis that increasing increase risk sepsis. In observational MR...
Lower urinary tract symptoms particularly affect older men and their quality of life. General practitioners currently have no easily available assessment tools to diagnose lower symptom causes. Referrals urology specialists are increasing. practitioner access simple, accurate tests clinical decision could facilitate management in primary care. To determine which several index combination, best predicted three diagnoses (detrusor overactivity, bladder outlet obstruction and/or detrusor...
Objective To describe the incidence and key demographic, socioeconomic clinical characteristics of individuals with liver disease in Wales. Design setting This study is designed as a retrospective observational that linked data anonymised identified from primary, secondary care mortality Secure Anonymised Information Linkage (SAIL) Databank Participants All Welsh residents who registered SAIL-contributing general practitioner (GP) diagnosed 2004 to 2022. Primary outcome measures Our primary...
Abstract Background Acute sore throat is managed in community pharmacies England and Wales under different clinical pathways: Sore Throat Pharmacy First (ASTPF) Test Treat (STTT), respectively. ASTPF launched 2024 allows antibiotic supply with FeverPAIN scores 4 5. STTT 2018 ≥2 or Centor ≥3, if point-of-care testing confirms presence of group A Streptococcus (GAS). Objectives To compare rates STTT, between 1 February 30 July 2024, covering the first 6 months ASTPF. Methods descriptive study...
Background Cardiovascular disease (CVD) events triggered by inflammation are an underappreciated and poorly quantified cause of morbidity mortality in patients with bloodstream infections (BSIs). We aimed to determine the risk myocardial infarction (MI) stroke after BSI. Methods This self-controlled case series study was conducted within Secure Anonymised Information Linkage Databank, containing anonymised population-scale electronic health record data for Wales, UK. included adults...
To date, no research has compared longer-term outcomes (antibiotic provision; re-consultations; hospital admissions for quinsy; cost-effectiveness) following presentation with acute sore throat at general practice (GP) versus newer, pharmacy-led services.
A National Health Service (NHS)-funded sore throat test and treat (STTT) service was introduced in selected pharmacies two local health boards Wales, as an extension to the national pharmacy common ailment scheme. The aim of this study evaluate impact STTT on provision quality patient care, namely antibiotic use, safety general practitioner (GP) consultation rates.
Abstract Background clinical guidelines recommend antibiotic prophylaxis for preventing recurrent urinary tract infections (UTIs), but there is little evidence their effectiveness in older adults. Methods this was a retrospective cohort study of health records from 19,696 adults aged ≥65 with UTIs. We used prescription to ascertain ≥3 months’ trimethoprim, cefalexin or nitrofurantoin. random effects Cox event models estimate hazard ratios (HR) and 95% confidence intervals (CI) risks...
Background Few studies have investigated the risk of adverse outcomes in older people with renal impairment presenting to primary care a urinary tract infection (UTI). The aim this study was determine patients aged ≥65 years UTI, by estimated glomerular filtration rate (eGFR) and empirical prescription nitrofurantoin versus trimethoprim. Methods findings This retrospective cohort using linked health record data from 795,484 393 general practices England, who were between 2010 2016. Patients...
The community pharmacy-led Sore Throat Test and Treat (STTT) service in Wales allowed pharmacists to undertake a structured clinical assessment with FeverPAIN/Centor scores point-of-care test (POCT) for Group A Streptococcus (GAS) infection. new model was temporarily agreed as result of COVID-19, without routine use POCT.To explore the impact removing requirement GAS POCT from pharmacy STTT on antibiotic supply.Analysis consultation data, obtained two periods: November 2018 (date went live)...