A5068118534- Cardiac, Anesthesia and Surgical Outcomes
- Frailty in Older Adults
- Colorectal Cancer Surgical Treatments
- Hip and Femur Fractures
- Appendicitis Diagnosis and Management
- COVID-19 and healthcare impacts
- Enhanced Recovery After Surgery
- Nutrition and Health in Aging
- Abdominal Surgery and Complications
- Colorectal Cancer Screening and Detection
- Stoma care and complications
- Intraperitoneal and Appendiceal Malignancies
- Trauma and Emergency Care Studies
- Hepatocellular Carcinoma Treatment and Prognosis
- Pancreatic and Hepatic Oncology Research
- Surgical Simulation and Training
- Delphi Technique in Research
- Gastric Cancer Management and Outcomes
- COVID-19 Clinical Research Studies
- Pelvic and Acetabular Injuries
- Diversity and Career in Medicine
- Intensive Care Unit Cognitive Disorders
- Patient-Provider Communication in Healthcare
- Healthcare cost, quality, practices
- Ultrasound and Hyperthermia Applications
Royal Alexandra Hospital
2016-2025
University of Glasgow
2013-2025
Golden Jubilee National Hospital
2022-2025
NHS Greater Glasgow and Clyde
2015-2024
University of the West of Scotland
2024
Musgrove Park Hospital
2023
Laboratoire des Sciences de l'Ingénieur, de l'Informatique et de l'Imagerie
2020-2022
University of Liverpool
2021
Society of Surgical Oncology
2021
Hospital Italiano de Buenos Aires
2021
This study aimed to document the prevalence of frailty in older adults undergoing emergency laparotomy and explore relationships between postoperative morbidity mortality.The majority are (≥65 y) that carry highest mortality. Improved understanding is urgently needed allow development targeted interventions.An observational multicenter (n=49) UK was performed (March-June 2017). All were included. Preoperative score calculated using progressive Clinical Frailty Score (CFS): 1 (very fit) 7...
Abstract Background C-reactive protein (CRP) is a non-specific acute phase reactant elevated in infection or inflammation. Higher levels indicate more severe and have been used as an indicator of COVID-19 disease severity. However, the evidence for CRP prognostic marker yet to be determined. The aim this study examine response patients hospitalized with determine utility on admission predicting inpatient mortality. Methods Data were collected between 27 February 10 June 2020, incorporating...
The aim of the study was to assess clinical value contrast-enhanced intraoperative ultrasound (CE-IOUS) as a novel tool in hepatic staging patients undergoing liver resection.Sixty scheduled undergo resection for metastatic disease were studied. Preoperative with CT and/or MR scans performed within 2 6 weeks operation. Following exploration, (IOUS) using an HDI-5000 scanner (Philips) and finger-probe pulse inversion harmonic (PIH) capability. CE-IOUS PIH mode standardized protocol (low MI:...
frail patients in any age group are more likely to die than those that not frail. We aimed evaluate the impact of frailty on clinical mortality, readmission rate and length stay for emergency surgical all ages. a multi-centre prospective cohort study was conducted adult admissions acute units. Every patient presenting as secondary care, regardless whether they ultimately underwent procedure included. The carried out during 2015 2016. Frailty defined using 7-point Clinical Scale. primary...
Acute appendicitis (AA) is the most common general surgical emergency. Early laparoscopic appendicectomy gold-standard management. SARS-CoV-2 (COVID-19) brought concerns of increased perioperative mortality and spread infection during aerosol generating procedures: as a consequence, conservative management was advised, open recommended when surgery unavoidable. This study describes impact first weeks pandemic on AA in United Kingdom (UK).
For the creation of scaffolds in tissue engineering applications, it is essential to control physical morphology fibres and choose compositions which do not disturb normal physiological function. Collagen, most abundant protein human body, a well-established biopolymer used electrospinning compositions. It shows high in-vivo stability able maintain biomechanical strength over time. In this study, effects collagen type I polylactic acid-drug electrospun for applications are examined. The...
Abstract Aim Rectal cancer patients undergoing neoadjuvant chemoradiotherapy (NACRT) experience physical deterioration and reductions in their quality of life. This feasibility study assessed prehabilitation (a walking intervention) before, during after NACRT to inform a definitive multi‐centred randomized clinical trial (REx trial). Methods Patients planned for followed by potentially curative surgery were approached (August 2014–March 2016) ( www.isrctn.com ; 62859294). Prior NACRT,...
The purpose of this study was to assess the clinical value and potential impact SonoVue-enhanced sonography in characterization focal liver lesions.This included 127 patients with 82 malignant 52 benign lesions liver. Contrast-enhanced performed using nonlinear imaging modes at low mechanical index (0.1-0.3) enable real-time visualization arterial, portal, late-phase enhancement. Digital recordings unenhanced contrast-enhanced were reviewed by on-site investigators two off-site blinded...
Objectives Multimorbidity is the presence of 2 or more medical conditions. This increasingly used assessment has not been assessed in a surgical population. The objectives this study were to assess prevalence multimorbidity and its association with common outcome measures. Design A cross-sectional observational study. Setting UK-based multicentre study, included participants between July October 2014. Participants Consecutive emergency (non-elective) general patients admitted hospital, aged...
The chemical distribution and mechanical effects of drug compounds in loaded electrospun scaffolds, a potential material for hernia repair mesh, were characterised the efficacy was evaluated. Polycaprolactone fibres with either antibacterial agent, irgasan, or broad-spectrum antibiotic, levofloxacin. samples subsequently by rheological studies, scanning electron microscopy (SEM), atomic force (AFM), contact angle goniometry (CAG), vitro release studies time-of-flight secondary ion mass...
Abstract Background Surgical services are preparing to scale up in areas affected by COVID-19. This study aimed evaluate the association between preoperative SARS-CoV-2 testing and postoperative pulmonary complications patients undergoing elective cancer surgery. Methods international cohort included adult surgery for 19 April 2020. Patients suspected of infection before operation were excluded. The primary outcome measure was at 30 days after Preoperative strategies adjusted confounding...
Coronavirus disease 2019 (COVID-19) infection causes acute lung injury, resulting from aggressive inflammation initiated by viral replication. There has been much speculation about the potential role of non-steroidal inflammatory drugs (NSAIDs), which increase expression angiotensin-converting enzyme 2 (ACE2), a binding target for severe respiratory syndrome coronavirus (SARS-CoV-2) to enter host cell, could lead poorer outcomes in COVID-19 disease. The aim this study was examine association...
Uncomplicated acute appendicitis can be managed with non-operative (antibiotic) treatment, but laparoscopic appendicectomy remains the first-line management in UK. During COVID-19 pandemic practice altered, more patients offered antibiotics as treatment. A large-scale observational study was designed comparing operative and of appendicitis. The aim this to evaluate 90-day follow-up.
Alternative lymph node (LN) parameters have been proposed to improve staging in colorectal cancer. This study compared these alternative with conventional TNM predicting long-term survival patients undergoing curative resection. A total of 295 consecutive (mean age 70 years; range 39–95; s.d. 10.4) underwent resection for cancer from 2001 2004. Age, sex, primary tumour site, stage and chemotherapy/radiotherapy were recorded. Patients colon rectal cancers analysed separately LN parameters:...
Colorectal cancer remains a common cause of death in the UK, with surgery being mainstay treatment. An objective measurement suitability each patient for surgery, and their risk–benefit calculation, would be great utility. We postulate that sarcopenia (low muscle mass) could fulfil this role as prognostic indicator. The aim study was to determine relationship between long-term outcomes patients undergoing elective bowel resection colorectal cancer. One hundred sixty-three consecutive who had...
Abstract Background Patients with rectal cancer who present sarcopenia (low muscle mass) are at significantly greater risk of postoperative complications and reduction in disease-free survival. We performed a subanalysis randomised controlled study [the REx trial; www.isrctn.com ; 62859294] to assess the potential prehabilitation modify mass patients having neoadjuvant chemoradiotherapy (NACRT). Methods scheduled for NACRT, then potentially curative surgery (August 2014–March 2016) had...
Patients eligible for emergency laparotomy who do not proceed to surgery are as well characterised patients surgery. We studied laparotomy, defined by National Emergency Laparotomy Audit criteria, from August 2015 October 2016. analysed the association of individual variables with survival and two composite scores: P-POSSUM a general model. Out 314 patients, 214 (68%) underwent 100 (32%) did not. Median (IQR [range]) follow-up was 1.3 (0.1-1.8 [0.0-2.5]) years cohort, 1.5 (1.1-2.0 [0.0-2.6])...