A5026006735- Parathyroid Disorders and Treatments
- Cardiac, Anesthesia and Surgical Outcomes
- Adrenal and Paraganglionic Tumors
- Frailty in Older Adults
- Thyroid and Parathyroid Surgery
- Hormonal Regulation and Hypertension
- Pituitary Gland Disorders and Treatments
- Hip and Femur Fractures
- Thyroid Cancer Diagnosis and Treatment
- Intensive Care Unit Cognitive Disorders
- Pancreatic and Hepatic Oncology Research
- Genetic Syndromes and Imprinting
- Esophageal and GI Pathology
- Kidney Stones and Urolithiasis Treatments
- Magnesium in Health and Disease
- COVID-19 Clinical Research Studies
- Venous Thromboembolism Diagnosis and Management
- Long-Term Effects of COVID-19
- Acute Kidney Injury Research
- Cancer, Hypoxia, and Metabolism
- Gallbladder and Bile Duct Disorders
- Head and Neck Anomalies
- Pancreatitis Pathology and Treatment
- Dermatological and Skeletal Disorders
- Adipose Tissue and Metabolism
University Hospital of Wales
2016-2025
Cardiff and Vale University Health Board
2019-2024
Cardiff University
2015-2022
University of Wales
2021
University of Birmingham
2020
University of Oxford
2008-2019
Oxford Centre for Diabetes, Endocrinology and Metabolism
2007-2019
Marymount University
2017
Churchill Hospital
2007-2013
John Radcliffe Hospital
2008-2012
Abstract Background C-reactive protein (CRP) is a non-specific acute phase reactant elevated in infection or inflammation. Higher levels indicate more severe and have been used as an indicator of COVID-19 disease severity. However, the evidence for CRP prognostic marker yet to be determined. The aim this study examine response patients hospitalized with determine utility on admission predicting inpatient mortality. Methods Data were collected between 27 February 10 June 2020, incorporating...
frail patients in any age group are more likely to die than those that not frail. We aimed evaluate the impact of frailty on clinical mortality, readmission rate and length stay for emergency surgical all ages. a multi-centre prospective cohort study was conducted adult admissions acute units. Every patient presenting as secondary care, regardless whether they ultimately underwent procedure included. The carried out during 2015 2016. Frailty defined using 7-point Clinical Scale. primary...
Genetic abnormalities, such as those of multiple endocrine neoplasia type 1 (MEN1) and Cyclin D1 (CCND1) genes, occur in <50% nonhereditary (sporadic) parathyroid adenomas. To identify genetic abnormalities adenomas by whole-exome sequence analysis. Whole-exome analysis was performed on leukocyte DNA samples from 16 postmenopausal women without a family history tumors or MEN1 whom primary hyperparathyroidism due to single-gland disease cured surgery. Somatic variants confirmed this discovery...
Heterozygous mutations of GATA3, which encodes a dual zinc-finger transcription factor, cause hypoparathyroidism with sensorineural deafness and renal dysplasia. Here, we have investigated the role GATA3 in parathyroid function by challenging Gata3+/- mice diet low calcium vitamin D so as to expose any defects function. This led higher mortality among compared Gata3+/+ mice. Compared their wild-type littermates, had lower plasma concentrations hormone (PTH) smaller glands reduced Ki-67...
Objectives Multimorbidity is the presence of 2 or more medical conditions. This increasingly used assessment has not been assessed in a surgical population. The objectives this study were to assess prevalence multimorbidity and its association with common outcome measures. Design A cross-sectional observational study. Setting UK-based multicentre study, included participants between July October 2014. Participants Consecutive emergency (non-elective) general patients admitted hospital, aged...
Coronavirus disease 2019 (COVID-19) infection causes acute lung injury, resulting from aggressive inflammation initiated by viral replication. There has been much speculation about the potential role of non-steroidal inflammatory drugs (NSAIDs), which increase expression angiotensin-converting enzyme 2 (ACE2), a binding target for severe respiratory syndrome coronavirus (SARS-CoV-2) to enter host cell, could lead poorer outcomes in COVID-19 disease. The aim this study was examine association...
Physiological studies of mice are facilitated by normal plasma and 24-hour urinary reference ranges, but variability these parameters may increase due to stress that is induced housing in metabolic cages. We assessed daily weight, food water intake, urine volume final day measurements the following: sodium, potassium, chloride, urea, creatinine, calcium, phosphate, alkaline phosphatase, albumin, cholesterol glucose; glucose protein 24- 30-week-old C3H/HeH, BALB/cAnNCrl C57BL/6J mice. Between...
ABSTRACT Background Traditional teaching dictated that patients with recurrent thyroid cysts undergo excision owing to a 12% risk malignancy. Ultrasound evaluation now determines management of these augmented by fine needle biopsy. In UK, non‐diagnostic category for (Thy1c) exists, whereas the Bethesda system combines ‘non‐diagnostic—cyst fluid only’ into Category I along paucicellular and acellular results. The aim was assess ability Thy1c cytology exclude Methods We undertook retrospective...
Postoperative outcomes of patients with normotensive pheochromocytomas are poorly documented. We aimed to evaluate the impact preoperative hypertension on post-operative following adrenalectomy for pheochromocytoma. An international retrospective study undergoing pheochromocytoma in 46 centers between 2012-2022 was performed. Hypertensive and were defined respectively by presence or absence history before at time diagnosis. To differences postoperative hypertensive patients, propensity score...
Evidence from clinical and experimental data suggests that thyrotropin receptor (TSHR) signalling is involved in energy expenditure through its impact on white (WAT) brown (BAT) adipose tissues. TSHR expression increases during mesenchymal stem cell (MSC) differentiation into fat. We hypothesize activation (TSHR*, elevated TSH, thyroid stimulating antibodies (TSAB) or activating mutation), influences MSC differentiation, which contributes to body composition changes seen hypothyroidism...
During the COVID-19 pandemic continuation or cessation of angiotensin-converting enzyme inhibitors (ACEi) and angiotensin receptor blockers (ARBs) has been contentious. Mechanisms have proposed for both beneficial detrimental effects. Recent studies focused on mortality with no literature having examined length hospital stay. The aim this study was to determine influence ACEi ARBs stay.COPE (COVID-19 in Older People) is a multicenter observational including adults all ages admitted either...
Hypercalciuria is a major cause of nephrolithiasis, and common complex disorder involving genetic environmental factors. Identification factors for monogenic forms hypercalciuria hampered by the limited availability large families, to facilitate such studies, we screened in mice from an N-ethyl-N-nitrosourea mutagenesis programme. We identified mouse with autosomal dominant (HCALC1). Linkage studies mapped Hcalc1 locus 11.94 Mb region on chromosome 6 containing transient receptor potential...
The COVID-19 pandemic has placed significant pressure on health and social care. Survivors of may be left with substantial functional deficits requiring ongoing We aimed to determine whether pre-admission frailty was associated increased care needs at discharge for patients admitted hospital COVID-19.Patients were included if aged over 18 years old between 27 February 10 June 2020. Clinical Frailty Scale (CFS) used assess status. Admission levels recorded. Data analysed using a mixed-effects...
This protocol describes an observational study which set out to assess whether frailty and/or multimorbidity correlates with short-term and medium-term outcomes in patients diagnosed COVID-19 a European, multicentre setting.Over 3-month period we aim recruit minimum of 500 across 10 hospital sites, collecting baseline data including: patient demographics; presence comorbidities; relevant blood tests on admission; prescription ACE inhibitors/angiotensin receptor blockers/non-steroidal...
Abstract Background There is a surgeon volume–outcome effect in adrenal surgery but the threshold for high-volume remains controversial. This study aimed to determine predictors of high-risk operations and explore whether these should be restricted surgeons. Methods Patients undergoing registered United Kingdom Registry Endocrine Thyroid Surgery between 2004 2021 were analysed. Outcomes included postoperative complications, duration hospital stay, mortality. Factors multivariable analysis...