A5100735940- Cardiovascular and exercise physiology
- Muscle metabolism and nutrition
- Nutrition and Health in Aging
- Cardiac, Anesthesia and Surgical Outcomes
- Hemodynamic Monitoring and Therapy
- Anesthesia and Pain Management
- Sports Performance and Training
- Pain Management and Opioid Use
- Colorectal Cancer Surgical Treatments
- Muscle Physiology and Disorders
- Renal function and acid-base balance
- Diet and metabolism studies
- Heart Rate Variability and Autonomic Control
- Adipose Tissue and Metabolism
- Anorectal Disease Treatments and Outcomes
- Cardiac Health and Mental Health
- Exercise and Physiological Responses
- Physical Activity and Health
- Acute Kidney Injury Research
- Appendicitis Diagnosis and Management
- Frailty in Older Adults
- Cardiovascular Health and Disease Prevention
- Pelvic and Acetabular Injuries
- Blood Pressure and Hypertension Studies
- Enhanced Recovery After Surgery
University of Nottingham
2015-2024
Royal Derby Hospital
2014-2023
Nottingham Biomedical Research Centre
2017-2023
Versus Arthritis
2013-2023
National Institute for Health Research
2017-2023
University Hospitals of Derby and Burton NHS Foundation Trust
2020-2022
Medical Research Council
2014-2021
Université Paris-Est Créteil
2017
University of Cambridge
2017
NHS Blood and Transplant
2017
Maintenance of skeletal muscle mass is contingent upon the dynamic equilibrium (fasted losses-fed gains) in protein turnover. Of all nutrients, single amino acid leucine (Leu) possesses most marked anabolic characteristics acting as a trigger element for initiation synthesis. While mechanisms by which Leu 'sensed' have been subject great scrutiny, branched-chain acid, can be catabolized within muscle, thus posing possibility that metabolites could involved mediating effect(s) Leu. Our...
We investigated architectural, functional and molecular responses of human skeletal muscle to concentric (CON) or eccentric (ECC) resistance training (RT).Twelve young males performed 10 weeks (RT) (n = 6 CON, ECC). An additional 14 were recruited evaluate acute fascicle behaviour signalling in biopsies collected from vastus lateralis (VL) after 30 min single bouts CON ECC exercise. VL volume was measured by magnetic resonance imaging. Muscle architecture (fascicle length, Lf; pennation...
Radiologically assessed muscle mass has been suggested as a surrogate marker of functional status and frailty may predict patients at risk postoperative complications. We hypothesize that sarcopenia negatively impacts on recovery is predictive complications.One hundred undergoing elective resection for colorectal carcinoma were included in this study. Lean was estimated by measuring the cross-sectional area psoas level third lumbar vertebra identified preoperative CT scan, normalizing...
Physical activity and molecular ageing presumably interact to precipitate musculoskeletal decline in humans with age. Herein, we have delineated networks for these two major components of sarcopenic risk using multiple independent clinical cohorts. We generated genome-wide transcript profiles from individuals (n = 44) who then undertook 20 weeks supervised resistance-exercise training (RET). Expectedly, our subjects exhibited a marked range hypertrophic responses (3% +28%), when applying...
Quantification of muscle protein synthesis (MPS) remains a cornerstone for understanding the control mass. Traditional [ 13 C]amino acid tracer methodologies necessitate sustained bed rest and intravenous cannulation(s), restricting studies to ∼12 h, thus cannot holistically inform on diurnal MPS. This limits insight into regulation habitual metabolism in health, aging, disease while querying utility techniques predict long-term efficacy anabolic/anticatabolic interventions. We tested D 2 O...
Impaired anabolic responses to nutrition and exercise contribute loss of skeletal muscle mass with ageing (sarcopenia). Here, we tested protein synthesis (MPS), in the under represented group older women, leucine-enriched essential amino acids (EAA) comparison a large bolus whey (WP).Twenty-four women (65 ± 1 y) received (N = 8/group) 1.5 g EAA supplements (LEAA_1.5), 6 LEAA (LEAA_6) 40 WP. A primed constant I.V infusion 13C6-phenylalanine was used determine MPS at baseline response feeding...
This study aimed to determine for continuous outcomes dependent on baseline risk, whether funnel plot asymmetry may be due statistical artefact rather than publication bias and evaluate a novel test resolve this. Firstly, we conducted assessment in nine meta‐analyses of postoperative analgesics (344 trials with 25 348 participants). Secondly, attempted the observed by considering meta‐regression residuals as outcome (rather mean difference) (inverse) sample size exploratory variable SE)....
BACKGROUND. The impact of resistance exercise training (RE-T) across the life span is poorly defined.
Compromised limb blood flow in aging may contribute to the development of sarcopenia, frailty, and metabolic syndrome. We developed a novel contrast-enhanced ultrasound technique using Sonovue™ characterize muscle microvasculature responses an oral feeding stimulus (15 g essential amino acids) young (~20 years) older (~70 men. Intensity-time replenishment curves were made via probe “fixed” over quadriceps, with intermittent high mechanical index destruction microbubbles within vasculature....
We recently reported that the greatest distinguishing feature between eccentric (ECC) and concentric (CON) muscle loading lays in architectural adaptations: ECC favors increases fascicle length (Lf), associated with distal vastus lateralis (VL) hypertrophy, CON pennation angle (PA). Here, we explored interactions structural morphological remodeling, assessed by ultrasound dual x-ray absorptiometry (DXA), long-term protein synthesis (MPS), evaluated deuterium oxide (D2O) tracing technique....
Radiologically defined sarcopenia has been shown to predict negative outcomes after cancer surgery, however radiological assessment of often requires additional software and standardisation against anthropomorphic data. Measuring psoas density using hospital Picture Archiving Communication Systems (PACS), universally available in the UK, may have advantages over methods requiring use specialist costly software. The aim this study was assess association between radiologically measured by...
Abstract Objectives To assess the efficacy of high-intensity interval training (HIIT) for improving cardiorespiratory fitness (CRF) in patients awaiting resection urological malignancy within four weeks. Subjects/patients and methods A randomised control trial consecutive aged (>65 years) scheduled major surgery a large secondary referral centre UK hospital. The primary outcome is change anaerobic threshold (VO 2AT ) following HIIT vs. standard care. Results Forty were recruited (mean age...
Background: The anabolic response of skeletal muscle to essential amino acids (EAAs) is dose dependent, maximal at modest doses, and short lived, even with continued EAA availability, a phenomenon termed “muscle-full.” However, the effect ingestion profile on metabolism remains undefined. Objective: We determined Bolus vs. Spread feeding in young men hypothesized that muscle-full regulated by dose-, not delivery profile–, dependent mechanism. Methods: provided 16 healthy 15 g mixed-EAA,...
Background & aimsβ-hydroxy-β-methylbutyrate (HMB) is purported as a key nutritional supplement for the preservation of muscle mass in health, disease and an ergogenic aid exercise. Of two available forms HMB (calcium (Ca-HMB) salt or free acid (FA-HMB)) – differences plasma bioavailability have been reported. We previously reported that ∼3 g oral FA-HMB increased protein synthesis (MPS) reduced breakdown (MPB). The objective present study was to quantify metabolism responses...