A5028735117- Cardiac, Anesthesia and Surgical Outcomes
- Cardiovascular and exercise physiology
- Colorectal Cancer Surgical Treatments
- Nutrition and Health in Aging
- Heart Rate Variability and Autonomic Control
- Cardiac Health and Mental Health
- Physical Activity and Health
- Appendicitis Diagnosis and Management
- Abdominal Trauma and Injuries
- Global Health and Surgery
- Liver Disease and Transplantation
- Abdominal Surgery and Complications
- Pelvic and Acetabular Injuries
- Surgical site infection prevention
- Blood Pressure and Hypertension Studies
- Hemodynamic Monitoring and Therapy
- Frailty in Older Adults
- Minimally Invasive Surgical Techniques
- Radiomics and Machine Learning in Medical Imaging
- Management of metastatic bone disease
- Spinal Hematomas and Complications
- Genetic and Kidney Cyst Diseases
- Enhanced Recovery After Surgery
- Occupational and environmental lung diseases
- Gallbladder and Bile Duct Disorders
Queen's Medical Centre
2019-2023
Royal Derby Hospital
2015-2023
University of Nottingham
2016-2023
Versus Arthritis
2020-2023
Nottingham Biomedical Research Centre
2019-2023
John Peter Smith Hospital
2023
National Institute for Health Research
2019-2023
University of Edinburgh
2018-2022
Medical Research Council
2018-2021
University of Warwick
2018
Abstract Objectives To assess the efficacy of high-intensity interval training (HIIT) for improving cardiorespiratory fitness (CRF) in patients awaiting resection urological malignancy within four weeks. Subjects/patients and methods A randomised control trial consecutive aged (>65 years) scheduled major surgery a large secondary referral centre UK hospital. The primary outcome is change anaerobic threshold (VO 2AT ) following HIIT vs. standard care. Results Forty were recruited (mean age...
<b>Background:</b> Liver transplantation is a very successful therapy for those with end stage disease. Although there are numerous data on patient and graft survival after liver transplantation, life expectancy possible loss of (compared normal matched population) in who survive remains unknown. <b>Aims:</b> To assess the years lost adult allograft recipients, compared an age sex UK population to provide patients more information improve use scarce resource. <b>Methods:</b> Using National...
Supervised high-intensity interval training (HIIT) can rapidly improve cardiorespiratory fitness (CRF). However, the effectiveness of time-efficient unsupervised home-based interventions is unknown. Eighteen volunteers completed either: laboratory-HIIT (L-HIIT); home-HIIT (H-HIIT) or home-isometric hand-grip (H-IHGT). CRF improved significantly in L-HIIT and H-HIIT groups, with blood pressure improvements H-IHGT group only. offers a practical, exercise mode to CRF, away from laboratory...
Background Pre‐operative cardiorespiratory fitness (CRF) in colorectal cancer (CRC) patients has been shown to affect post‐operative outcomes. The aim of this study was test the feasibility high‐intensity interval training (HIIT) for improving pre‐operative CRC within 31‐day waiting‐time targets imposed UK. Methods Eighteen (13 males, mean age: 67 years (range: 52‐77 years) participated supervised HIIT on cycle ergometers 3 or 4 times each week prior surgery. Exercise intensity during 5 ×...
Current evidence suggests that pelvic floor reconstruction following extralevator abdominoperineal excision of rectum (ELAPER) may reduce the risk perineal herniation intra-abdominal contents. Options for include mesh and myocutaneous flaps, which long-term follow-up data is lacking. The aim this study was to evaluate outcomes biological (Surgisis®, Biodesign™) ELAPER. A retrospective review all patients having ELAPER in a single institution between 2008 2018 perfomed. Clinic letters were...
High-intensity interval training (HIIT) has been shown to be more effective than moderate continuous aerobic exercise for improving cardiorespiratory fitness (CRF) in a limited time frame. However, the length of required HIIT elicit clinically significant improvements CRF older adults is currently unknown. The aim this study was compare changes completing identical protocols varying durations.
Background The aims of this study were to determine if patient ASA grade was associated with increased stress in anaesthetists a subsequent effect on non‐technical skills. Methods Stress measured using validated objective (heart rate variability or heart rate) and subjective tool. We studied eight consultant at baseline (rest) during 16 episodes intubation an 1 2 vs. 3 4 patient. primary outcome for the between both groups. Secondary outcomes skill ratings association measurements. Results...
Cavernous haemangiomas are the most common tumour of liver; they benign in nature and have an incidence up to 7.3% at autopsy. Occasionally, may cause symptoms necessitating intervention. We report case a woman who presented with non-specific abdominal pain evidence giant hepatic haemangioma on imaging. She underwent selective arteriography transcatheter arterial embolisation followed by same-day left hemi-hepatectomy, making uneventful recovery. discuss management present same day prior...
Cardiovascular disease (CVD) is the leading cause of death worldwide. Many risk factors for CVD can be modified pharmacologically; however, uptake medications low, especially in asymptomatic people. Exercise also effective at reducing risk, but adoption poor with time-commitment and cost cited as key reasons this. Repeated remote ischaemic preconditioning (RIPC) isometric handgrip (IHG) training are both inexpensive, time-efficient interventions which have shown some promise blood pressure...
Introduction Patients with peripheral arterial disease (PAD), aneurysmal (AD) or carotid atherosclerosis are at high cardiovascular risk, necessitating secondary protection. The aim of this study was to determine compliance risk reduction guidelines in new patients referred vascular clinics. Methods A multicentre collaborative national observational audit eight tertiary general clinics over a three-month period England and Wales conducted by the Vascular Endovascular Research Network (VERN)....
Abstract Background Cardiorespiratory fitness (CRF) has important implications for post‐operative recovery. The timed‐up‐and‐go (TUG) test is a cheap and simple method to assess patient's functional performance; although how well TUG correlates with results of cardiopulmonary exercise (CPET), the gold standard measure CRF unknown. Therefore, aim this study was correlation between CPET‐derived parameters times in group older adults. Methods Ninety‐eight independent community dwelling adults...
To assess whether preoperative radiologically defined lean muscle measures are associated with adverse clinical outcomes in patients undergoing elective surgery for colorectal cancer.This retrospective UK-based multicentre data collection study identified having had cancer resection curative intent between January 2013 to December 2016. Preoperative computed-tomography (CT) scans were used measure psoas characteristics. Clinical records provided postoperative morbidity and mortality...
Surgery for urological cancers is associated with high complication rates and survivors commonly experience fatigue, reduced physical ability quality of life. High-intensity interval training (HIIT) as surgical prehabilitation has been proven effective improving the cardiorespiratory fitness (CRF) cancer patients, however mechanistic basis this favourable adaptation undefined. Thus, we aimed to assess mechanisms physiological responses HIIT cancer.
PURPOSE: Operations for urological malignancy are increasing in number and complexity due to the advancing age of patients with multiple comorbidities. Low pre-operative cardiorespiratory fitness (CRF) muscle mass, both associated increased peri-operative morbidity mortality, as well poorer post-operative outcomes delayed return normal activities. High intensity interval training (HIIT) may represent an efficacious modality rapidly improve CRF body composition short clinically-dictated...