A5084898634- Diagnosis and Treatment of Venous Diseases
- Venous Thromboembolism Diagnosis and Management
- Peripheral Artery Disease Management
- Cardiac, Anesthesia and Surgical Outcomes
- Cerebrovascular and Carotid Artery Diseases
- Aortic aneurysm repair treatments
- Diabetic Foot Ulcer Assessment and Management
- Central Venous Catheters and Hemodialysis
- Surgical Simulation and Training
- Diversity and Career in Medicine
- Vascular Procedures and Complications
- Acute Ischemic Stroke Management
- Innovations in Medical Education
- Health and Medical Research Impacts
- Intracranial Aneurysms: Treatment and Complications
- Global Cancer Incidence and Screening
- Cardiovascular Health and Disease Prevention
- Atrial Fibrillation Management and Outcomes
- Infectious Aortic and Vascular Conditions
- Atherosclerosis and Cardiovascular Diseases
- Renal Transplantation Outcomes and Treatments
- Metabolomics and Mass Spectrometry Studies
- Infective Endocarditis Diagnosis and Management
- Protease and Inhibitor Mechanisms
- Healthcare Systems and Public Health
Imperial College London
2016-2025
Imperial College Healthcare NHS Trust
2015-2025
Health Data Research UK
2021-2025
St Mary's Hospital
2020-2025
Charing Cross Hospital
2012-2024
St. Mary's Hospital
2020-2024
Imperial Valley College
2017-2024
London Cancer
2024
St. Mary’s Hospital
2023
NIHR Imperial Biomedical Research Centre
2022-2023
We sought to determine whether intraplaque inflammation could be measured with positron emission tomography/computed tomography angiography (PET/CTA) using 11C-PK11195, a selective ligand of the translocator protein (18 kDa) (TSPO) which is highly expressed by activated macrophages. Patients (n = 32; mean age 70 ± 9 years) carotid stenoses 36; symptomatic and 27 asymptomatic) underwent 11C-PK11195 PET/CTA imaging. uptake into plaques was target-to-background ratios (TBR). On CTA images,...
Background— Trends in cardiovascular mortality across Europe demonstrate significant geographical variation, and an understanding of these trends has a central role global public health. Methods Results— Ischemic heart disease cerebrovascular age-standardized death rates (as per International Classification Diseases , ninth tenth revisions) were collated from the World Health Organization database for member states European Union. characterized by using Joinpoint regression analysis. An...
Abstract Introduction The neutrophil-to-lymphocyte ratio (NLR) is a biological marker that has been shown to be associated with outcomes in patients number of different malignancies. objective this study was assess the relationship between NLR and mortality population adult critically ill patients. Methods We performed an observational cohort unselected intensive care unit (ICU) based on records large clinical database. computed individual patient categorized by quartile ratio. association...
The best method to teach anatomy continues be widely debated. Many UK medical schools have recently changed their course structure with the use of cadaveric dissection declining. A recent study by Patel and Moxham ([ 2008] Clin. Anat. 21:182-189) found that professional anatomists viewed most suitable fulfil anatomical learning outcomes. opinion 580 second year students across two was surveyed. methodology similar employed aimed explore which teaching methods considered a prescribed set...
Background— We sought to perform a systematic lipid analysis of atherosclerotic plaques using emerging mass spectrometry techniques. Methods and Results— A chip-based robotic nanoelectrospray platform interfaced triple quadrupole spectrometer was adapted analyze lipids in tissue sections extracts from human endarterectomy specimens by shotgun lipidomics. Eighteen scans for different classes plus additional fatty acids resulted the detection 150 species 9 which 24 were detected...
Abstract Innate inflammation is a hallmark of both experimental and human atherosclerosis. The predominant innate immune cell in the atherosclerotic plaque monocyte-macrophage. behaviour this type within heterogeneous depends on recruitment diverse monocyte subsets. Furthermore, microenvironment offers polarisation activation signals which impact phenotype. Microenvironmental are sensed through pattern recognition receptors, including toll-like NOD-like receptors thus dictating macrophage...
The identification of patients with high-risk atherosclerotic plaques prior to the manifestation clinical events remains challenging. Recent findings question histology- and imaging-based definitions "vulnerable plaque," necessitating an improved approach for predicting onset symptoms.We performed a proteomics comparison vascular extracellular matrix associated molecules in human carotid endarterectomy specimens from 6 symptomatic versus asymptomatic identify protein signature plaques....
To determine if the number of nontargeted microbubbles retained in human carotid plaque is sufficient to be detected with ultrasonography (US).The study protocol was approved by local research ethics committee. Informed consent obtained. A total 37 subjects atherosclerosis (mean age, 69.9 years; age range, 49-86 years), whom 27 (73%) were men 69.7 58-86 years) and 10 (27%) women 70.3 studied between December 2008 May 2009 late-phase (LP) contrast material-enhanced US using flash imaging a...
Current optimum medical treatments have had limited success in the primary prevention of cardiovascular events, underscoring need for new pharmaceutical targets and enhanced understanding mechanistic metabolic dysregulation. Here, we use a combination novel profiling methodologies, based on ultra-performance liquid chromatography coupled to mass spectrometry (UPLC–MS) followed by chemometric modeling, data integration, pathway mapping, create systems-level atlas atherogenesis. We apply this...
Previous research has suggested that patients with peripheral artery disease (PAD) are not offered adequate risk factor modification, despite their high cardiovascular risk. The aim of this study was to assess the profiles PAD and quantify survival benefits target-based modification.The Vascular Endovascular Research Network (VERN) prospectively collected from ten UK vascular centres (April June 2018) practice against European goal-directed best medical therapy guidelines. Risk control were...
Mentoring has been used extensively in the business world to enhance performance and maximise potential. Despite this, there is currently a paucity of literature describing mentoring for surgical trainees. This study examined current extent investigated future needs support this.An electronic, 47-item, self-administered questionnaire survey was distributed via national regional mailing lists websites through Association Surgeons Training Specialty Associations UK Republic Ireland.Overall,...
Abstract Objectives To investigate whether the use of graduated compression stockings (GCS) offers any adjuvant benefit when pharmaco-thromboprophylaxis is used for venous thromboembolism prophylaxis in patients undergoing elective surgery. Design Open, multicentre, randomised, controlled, non-inferiority trial. Setting Seven National Health Service tertiary hospitals United Kingdom. Participants 1905 surgical inpatients (≥18 years) assessed as being at moderate or high risk were eligible...
Background Malignant melanoma (MM) causes the highest absolute number of deaths among skin cancers. An up-to-date analysis international MM mortality trends is required for assessing burden disease, and may support assessment effectiveness new diagnostic, therapeutic preventative strategies. Objectives To report between 1985 2015 using World Health Organization (WHO) Mortality Database. Materials methods We used country-level data from WHO Database all countries with high usability death...
Abstract This observational study aimed to assess trends in type 2 diabetes mellitus (T2DM) disease burden European Union countries for the years 1990–2019. Sex specific T2DM age-standardised prevalence (ASPRs), mortality (ASMRs) and disability-adjusted life-year rates (DALYs) per 100,000 population were extracted from Global Burden of Disease (GBD) Study online results tool each EU country (inclusive United Kingdom), Trends analysed using Joinpoint regression analysis. Between 1990 2019,...