A5045979552- Cardiac, Anesthesia and Surgical Outcomes
- Cardiovascular and exercise physiology
- Colorectal Cancer Surgical Treatments
- Muscle metabolism and nutrition
- Nutrition and Health in Aging
- Hernia repair and management
- Diverticular Disease and Complications
- Intestinal and Peritoneal Adhesions
- Diet and metabolism studies
- Abdominal Surgery and Complications
- Anorectal Disease Treatments and Outcomes
- Pelvic floor disorders treatments
- Global Health and Surgery
- Cardiac Health and Mental Health
- COVID-19 and healthcare impacts
- Appendicitis Diagnosis and Management
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Muscle Physiology and Disorders
- Exercise and Physiological Responses
- Global Health Workforce Issues
- Adipose Tissue and Metabolism
- Innovations in Medical Education
- Genetics, Aging, and Longevity in Model Organisms
- Enhanced Recovery After Surgery
- Delphi Technique in Research
Nottingham University Hospitals NHS Trust
2023-2024
University of Nottingham
2015-2023
Royal Derby Hospital
2009-2022
Versus Arthritis
2020-2022
University of Edinburgh
2022
Nottingham Biomedical Research Centre
2019-2021
Medical Research Council
2020-2021
Queen Elizabeth Hospital Birmingham
2019
National Institute for Health Research
2019
Queen's Medical Centre
2019
Abstract Objectives To assess the efficacy of high-intensity interval training (HIIT) for improving cardiorespiratory fitness (CRF) in patients awaiting resection urological malignancy within four weeks. Subjects/patients and methods A randomised control trial consecutive aged (>65 years) scheduled major surgery a large secondary referral centre UK hospital. The primary outcome is change anaerobic threshold (VO 2AT ) following HIIT vs. standard care. Results Forty were recruited (mean age...
Small bowel obstruction is a common surgical emergency, and associated with high levels of morbidity mortality across the world. The literature provides little information on conservatively managed group. aim this study was to describe burden small in UK. This prospective cohort conducted 131 acute hospitals UK between January April 2017, delivered by trainee research collaboratives. Adult patients diagnosis mechanical were included. primary outcome in-hospital mortality. Secondary outcomes...
Stable isotope tracer methodologies are becoming increasingly widespread in metabolic research; yet a number of factors restrict their implementation, such as, i.v infusions, multiple cannulae, tissue samples, and significant cost. We recently validated the sensitivity orally administered stable deuterium oxide (D2O) for quantifying day-to-day changes muscle protein synthesis (MPS). This method is less invasive, restrictive, more cost-effective than traditional amino acid (AA) techniques. In...
The ability to rapidly generate and transfer muscle force is essential for effective corrective movements in order prevent a fall. aim of this study was establish the tendon contributions differences rate torque development (RTD) between younger (YM) older males (OM). Twenty-eight young (23.9 years ± 1.1) 22 old (68.5 0.5) were recruited assessment Quadriceps Anatomical CSA (ACSA), maximal voluntary contraction (MVC), (RTD), biomechanical properties. Activation capacity (AC), twitch df/dt)...
Age-related sarcopenia and dynapenia are associated with frailty metabolic diseases. Resistance exercise training (RET) adjuvant to evidence-based nutritional intervention(s) have been shown as mitigating strategies. Given that β-hydroxy-β-methyl-butyrate (HMB) supplementation during RET improves lean body mass in younger humans, we HMB acutely stimulates muscle protein synthesis (MPS) inhibits breakdown; hypothesized chronic of free acid (HMB-FA) would enhance MPS mass/function response...
Introduction: Healing rates for botulinum toxin injection anal fissure may be improved if combined with fissurectomy. This procedure has a decreased risk of incontinence, which is particularly important in females. We investigated the long-term efficacy fissurectomy and chronic resistant fissures Methods: Female patients who consented underwent excision edges 25-100 units into intersphincteric space. Patients were followed up 2 months after over period to 39 months. Results: Forty-six (mean...
Background Pre‐operative cardiorespiratory fitness (CRF) in colorectal cancer (CRC) patients has been shown to affect post‐operative outcomes. The aim of this study was test the feasibility high‐intensity interval training (HIIT) for improving pre‐operative CRC within 31‐day waiting‐time targets imposed UK. Methods Eighteen (13 males, mean age: 67 years (range: 52‐77 years) participated supervised HIIT on cycle ergometers 3 or 4 times each week prior surgery. Exercise intensity during 5 ×...
Validated diagnostics of skeletal muscle vitality could benefit clinical and basic science in terms mechanistic insights determining the efficacy interventions, e.g. exercise/pharmaceuticals/nutrients. We recently developed a Combined Oral Assessment Muscle (COSIAM) that can be used to simultaneously quantify whole-body mass (WBMM), protein synthesis (MPS) breakdown (MPB). Here, we aimed establish, cross-sectional fashion, links between COSIAM parameters established aspects function....
High-intensity interval training (HIIT) has been shown to be more effective than moderate continuous aerobic exercise for improving cardiorespiratory fitness (CRF) in a limited time frame. However, the length of required HIIT elicit clinically significant improvements CRF older adults is currently unknown. The aim this study was compare changes completing identical protocols varying durations.
The skeletal muscle anabolic effects of n-3 polyunsaturated fatty acids (n-3 PUFA) appear favoured towards women; a property that could be exploited in older women who typically exhibit poor growth responses to resistance exercise training (RET). Here we sought generate novel insights into the efficacy and mechanisms PUFA alongside short-term RET women.We recruited 16 healthy (Placebo n = 8 (PLA): 67±1y, 8: 64±1y) randomised double-blind placebo-controlled trial PUFA; 3680 mg/day versus PLA)...
Abstract Optimising approaches for measuring skeletal muscle mass and turnover that are widely applicable, minimally invasive cost effective is crucial in furthering research into sarcopenia cachexia. Traditional measurement of protein require infusion expensive, sterile, isotopically labelled tracers which limits the applicability these certain populations (e.g. clinical, frail elderly). To concurrently quantify i.e. synthesis (MPS) breakdown (MPB), elderly human volunteers using...
Optimization of resistance exercise (RE) remains a hotbed research for muscle building and maintenance.However, the interactions between contractile components RE (i.e.concentric (CON) eccentric (ECC)) age, are poorly defined.We used transcriptomics to compare age-related molecular responses acute CON ECC exercise.Eight young (21±1 y) eight older (70±1 exercise-naïve male volunteers had vastus lateralis biopsies collected at baseline 5 h post unilateral contralateral exercise.RNA was...
Resistance exercise (RE) remains a primary approach for minimising aging muscle decline.Understanding adaptation to individual contractile components of RE (eccentric, concentric) might optimise RE-based intervention strategies.Herein, we employed network-driven pipeline identify putative molecular drivers and contraction mode responses.RNA-sequencing data was generated from young (21±1 y) older (70±1 human skeletal before following acute unilateral concentric contralateral eccentric...
Abstract Background Abdominal wall hernia is a common surgical condition. Patients may present in an emergency with bowel obstruction, incarceration or strangulation. Small obstruction (SBO) serious condition associated significant morbidity. The aim of this study was to describe current management and outcomes patients obstructed the UK as identified National Audit Bowel Obstruction (NASBO). Methods NASBO collated data on adults treated for SBO at 131 hospitals between January March 2017....
Many conditions present as groin swellings, in both the elective and emergency setting. The management of these varies widely, thus a prompt accurate diagnosis is important.A 27 year old female presented with an acute painful swelling her right groin. A preliminary incarcerated femoral hernia led to urgent surgical exploration. Histology excised tissue showed appearances consistent endometriosis.Endometriosis unusual cause mass, which should be considered differential women childbearing age.
Pseudoaneurysms related to the superior mesenteric artery (SMA) are a recognised complication of trauma vessel, and successful treatment with stenting has been previously described. We report case patient who presented obstruction fourth part duodenum secondary traumatic pseudoaneurysm, hitherto unreported variant syndrome. Exclusion pseudoaneurysm relief duodenal were simultaneously achieved by placement covered stent.
Abstract Background Cardiorespiratory fitness (CRF) has important implications for post‐operative recovery. The timed‐up‐and‐go (TUG) test is a cheap and simple method to assess patient's functional performance; although how well TUG correlates with results of cardiopulmonary exercise (CPET), the gold standard measure CRF unknown. Therefore, aim this study was correlation between CPET‐derived parameters times in group older adults. Methods Ninety‐eight independent community dwelling adults...
The Early Years Consultant Network (EYCN) was created within the Association of Coloproctology Great Britain and Ireland in order to help new colorectal consultants their transition consultant practice. EYCN aims fill training gap leadership provide mentorship for surgeons during first five years independent During its inaugural year, worked at interface as two seem intertwined.
Abstract Aim Accurate post Long-course chemoradiotherapy treatment (LCCRT) allows safe selection of patients to rectal preservation without delaying resection in those with residual cancer. The aim this study was assess the accuracy radiological staging these patients. Methods Demographic and data from consecutive receiving LCCRT for cancer between May 2020 December 2021 collected. Local post-LCCRT compared pathological staging. Where had complete response (CRR) opted watch wait (WW)...