A5021796559- Esophageal and GI Pathology
- Esophageal Cancer Research and Treatment
- Gastric Cancer Management and Outcomes
- Lymphoma Diagnosis and Treatment
- Cardiac, Anesthesia and Surgical Outcomes
- Colorectal Cancer Surgical Treatments
- CAR-T cell therapy research
- Clinical practice guidelines implementation
- Enhanced Recovery After Surgery
- Colorectal Cancer Screening and Detection
- Innovations in Medical Education
- Chronic Lymphocytic Leukemia Research
- Abdominal Surgery and Complications
- Child Abuse and Trauma
- Criminal Justice and Corrections Analysis
- Appendicitis Diagnosis and Management
- Lung Cancer Diagnosis and Treatment
- Intestinal and Peritoneal Adhesions
- Health Systems, Economic Evaluations, Quality of Life
- Anesthesia and Sedative Agents
- Healthcare cost, quality, practices
- Delphi Technique in Research
- Reconstructive Surgery and Microvascular Techniques
- Breast Implant and Reconstruction
- Breast Cancer Treatment Studies
Roche (United Kingdom)
2022-2024
University Hospitals Bristol and Weston NHS Foundation Trust
2020-2024
University of Bristol
2018-2024
University Hospitals Bristol NHS Foundation Trust
2018-2024
Instituto Nacional de Enfermedades Neoplásicas
2023
American University of Beirut Medical Center
2023
National Research Center for Hematology Russian Academy of Medical Sciences
2023
Bristol Royal Infirmary
2022
Amsterdam University Medical Centers
2021
St Thomas' Hospital
2021
7008 Background: Glofitamab, a bispecific antibody with novel 2:1 (CD20:CD3) format, engages and redirects T cells to eliminate malignant B cells. In Phase I/II study (NCT03075696), fixed-duration glofitamab monotherapy showed high, durable complete responses (CR) manageable safety in patients (pts) heavily pretreated R/R MCL (Phillips et al. ASH 2022). We report updated efficacy data for pts MCL. Methods: Pts received obinutuzumab pretreatment (Gpt; 1000mg or 2000mg) 7 days before their...
Abstract Background Surgical mortality results are increasingly being reported and published in the public domain as indicators of surgical quality. This study examined how outlier status at 90 days after colorectal surgery compares with 30 subsequent intervals first year surgery. Methods All adults undergoing elective emergency resection between April 2001 February 2007 English National Health Service (NHS) Trusts were identified from administrative data. Funnel plots postoperative case...
Abstract Background Accurate assessment of surgical-site infection (SSI) is crucial for surveillance and research. Self-reporting patient measures are needed because current SSI tools limited assessing patients after leaving hospital. The Bluebelle Wound Healing Questionnaire (WHQ) was developed or observer completion; this study tested its acceptability, scale structure, reliability validity in with closed primary wounds abdominal surgery. Methods Patients completed the WHQ...
PURPOSE Patients with relapsed/refractory (R/R) mantle cell lymphoma (MCL) have a poor prognosis. The phase I/II NP30179 study (ClinicalTrials.gov identifier: NCT03075696 ) evaluated glofitamab monotherapy in patients R/R B-cell lymphomas, obinutuzumab pretreatment (Gpt) to mitigate the risk of cytokine release syndrome (CRS) glofitamab. We present data for MCL. METHODS Eligible MCL (at least one previous therapy) received Gpt (1,000 or 2,000 mg) 7 days before first dose (single split over 2...
Objective: To determine whether psychosocial factors moderate the relationship between surgical complications and quality of life (QoL). Background: Patients who experience have significantly worse postoperative QoL than patients with an uncomplicated recovery. Psychosocial factors, such as coping style level social support influence how people deal stressful events, but it is unclear they affect following a complication. These findings can inform development appropriate interventions that...
Introduction: Richter's transformation (RT) is characterized by of chronic lymphocytic leukemia to an aggressive lymphoma, most commonly CD20+ large B-cell lymphoma (LBCL). Prognosis for patients (pts) with RT poor and no standard care exists; there remains a major unmet medical need. Glofitamab T-cell engaging bispecific antibody (Ab) novel 2:1 (CD20:CD3) format. In Phase I/II study (NCT03075696), fixed-duration glofitamab monotherapy demonstrated durable responses manageable safety profile...
Objectives This study used national audit data to describe current management and outcomes of patients undergoing surgery for complications peptic ulcer disease (PUD), including perforation bleeding. It was also planned explore factors associated with fatal outcome after perforated ulcers. These analyses were designed provide a thorough understanding practice identify potentially modifiable as targets future quality improvement. Design National cohort using Emergency Laparotomy Audit (NELA)...
Following curricular revisions at the Virginia Commonwealth University School of Dentistry, this longitudinal study was designed to determine students' perceptions their educational experience in revised curriculum. A SWOT (Strengths, Weaknesses, Opportunities, and Threats) open‐ended response questionnaire administered students class 2011 (N=89) January each academic year, 2008 through 2011, followed by focus groups three months prior graduation. The overall rate for 69 percent, a total...
Purpose – The purpose of this paper is to consider and explore the principles that should inform a positive progressive approach conceptualising delivering youth justice. Design/methodology/approach Critical literature review, incorporating primary research evaluation conducted by authors. Findings A children first model justice cohere around promotion four key principles: children’s rights adults’ responsibilities; desistance inclusion; diversion systems management; relationship-based...
Abstract Background Surgery is the primary treatment that can offer potential cure for gastric cancer, but associated with significant risks. Identifying optimal surgical approaches should be based on comparing outcomes from well designed trials. Currently, trials report different outcomes, making synthesis of evidence difficult. To address this, aim this study was to develop a core outcome set (COS)—a standardized group important key international stakeholders—that reported by future in...
Brain metastases from colorectal cancer are rare, with an incidence of 0.6-4%. The risk and outcome brain after hepatic pulmonary metastasectomy have not been previously described. This study aimed to determine the incidence, predictive factors, treatment survival patients developing metastases, who had undergone resection metastases.A retrospective review was carried out a prospectively maintained database undergoing liver for metastases.Fifty-two (4.0%) 1304 were diagnosed metastases....
Abstract Background Randomised trials have shown an Enhanced Recovery Program (ERP) can shorten stay after colorectal surgery. Previous research has focused on patient compliance neglecting the role of care providers. National data implementation and adherence to standardised are lacking. We examined organisation delivery including ERP, correlated this with clinical outcomes. Methods A cross‐sectional questionnaire was administered surgeons nurses in August–October 2015. All English Health...
Test items created for dentistry examinations are often individually written by content experts. This approach to item development is expensive because it requires the time and effort of many experts but yields relatively few items. The aim this study was describe illustrate how can be generated using a systematic approach. Automatic generation (AIG) an alternative method that allows small number produce large numbers integrating their domain expertise with computer technology. article...
Abstract Background Abdominal wall hernia is a common surgical condition. Patients may present in an emergency with bowel obstruction, incarceration or strangulation. Small obstruction (SBO) serious condition associated significant morbidity. The aim of this study was to describe current management and outcomes patients obstructed the UK as identified National Audit Bowel Obstruction (NASBO). Methods NASBO collated data on adults treated for SBO at 131 hospitals between January March 2017....
Abstract Purpose This study examined knowledge, attitudes, perceptions, and awareness regarding antibiotic use among students academic faculty in US dental schools. Methods Two questionnaires, 1 for third‐year/fourth‐year the other deans/department chairs were administered electronically. Questions on demographics, educational formats, role of dentistry stewardship included. Knowledge about antibiotics was compared between third‐year fourth‐year using t‐test chi‐squared test at 0.05...
Administration of safe and effective local anesthesia is a cornerstone dental practice, but there some discrepancy in recommendations for maximum doses, with the Council on Dental Therapeutics American Academy Pediatric Dentistry's guidelines differing from manufacturers contemporary textbooks. The aim this study was to determine level uniformity across U.S. schools teaching maximal doses commonly used anesthetics. Faculty members primarily responsible students at all 62 that had graduated...
Surgical site infection (SSI) affects up to 20% of people with a primary closed wound after surgery. Wound dressings may reduce SSI. To assess the feasibility multicentre randomised controlled trial (RCT) evaluate effectiveness and cost-effectiveness dressing types or no SSI in surgical wounds. Phase A - semistructured interviews, outcome measure development, practice survey, literature reviews value-of-information analysis. B pilot RCT qualitative research questionnaire validation. Patients...
Introduction Transoral robotic surgery (TORS) has been adopted in some parts of the world as an innovative approach to resection oropharyngeal tumours. The development, details and outcomes early-to-later phase evaluation this technique quality evidence support its adoption into practice have hitherto not summarised. aim review is identify summarise early later studies of, for, TORS understand how report intervention governance procedures selection reporting optimise methods for using Idea,...
Laparoscopic colorectal cancer surgery has developed from unproven technique to mainstay of treatment. This study examined the application and relative outcomes laparoscopic open over time, as uptake experience have grown.Adults undergoing elective in English NHS during 2002-2012 were included. Age, sex, Charlson Comorbidity Index Multiple Deprivation compared time. Post-operative 30-day mortality, length stay, failure rescue reoperation associated mortality rate examined.Laparoscopy rates...